BREAKDOWN OF HIGH ENERGY PHOSPHATE COMPOUNDS IN BRAIN SLICES IN RELATION WITH AN INCREASE IN PERMEABILITY TO CATIONS
It was shown in our previous paper (1) that protoveratrine and EDTA caused a remarkable increase in passive permeability of the membrane of brain slices to cations and this increase was completely prevented by so-called stabilizers such as cocaine and calcium ion. Protoveratrine and EDTA are known t...
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| Veröffentlicht in: | Japanese journal of pharmacology 1963/12/01, Vol.13(3), pp.297-304 |
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| container_title | Japanese journal of pharmacology |
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| creator | YOSHIDA, HIROSHI FUJISAWA, HISAO KAJIKAWA, KOZO |
| description | It was shown in our previous paper (1) that protoveratrine and EDTA caused a remarkable increase in passive permeability of the membrane of brain slices to cations and this increase was completely prevented by so-called stabilizers such as cocaine and calcium ion. Protoveratrine and EDTA are known to be depolarizers (2) and the effects of these drugs on brain slices were considered to represent a model of natural excitation of the nerve cell membrane. An increase in respiration of brain slices by protoveratrine has been already reported by several investigators (3, 4). In this paper effects of protoveratrine, EDTA and cocaine on respiration and energy metabolism of brain slices are examined to know a relation between changes of membrane structure resulting in an increase in permeability and energy metabolism connected with it. |
| doi_str_mv | 10.1254/jjp.13.297 |
| format | Article |
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Protoveratrine and EDTA are known to be depolarizers (2) and the effects of these drugs on brain slices were considered to represent a model of natural excitation of the nerve cell membrane. An increase in respiration of brain slices by protoveratrine has been already reported by several investigators (3, 4). 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Protoveratrine and EDTA are known to be depolarizers (2) and the effects of these drugs on brain slices were considered to represent a model of natural excitation of the nerve cell membrane. An increase in respiration of brain slices by protoveratrine has been already reported by several investigators (3, 4). In this paper effects of protoveratrine, EDTA and cocaine on respiration and energy metabolism of brain slices are examined to know a relation between changes of membrane structure resulting in an increase in permeability and energy metabolism connected with it.</description><subject>Animals</subject><subject>Calcium</subject><subject>Calcium, Dietary</subject><subject>Cations</subject><subject>Cerebral Cortex</subject><subject>Cocaine</subject><subject>Coenzymes</subject><subject>Dinitrophenols</subject><subject>Edetic Acid</subject><subject>Guinea Pigs</subject><subject>Magnesium</subject><subject>Metabolism</subject><subject>Old Medline</subject><subject>Ouabain</subject><subject>Permeability</subject><subject>Pharmacology</subject><subject>Phosphates</subject><subject>Strophanthins</subject><subject>Veratrum</subject><issn>0021-5198</issn><issn>1347-3506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1unDAUha2qVTNNu-kDVF51UYkpF5u_JcM4AwqBERBFWVmuxzSg-YvNVOrbxxNG6aabax3fz5-sg9BXcOfg-fTnMBznQOZeHL5DMyA0dIjvBu_RzHU9cHyIoyv0yZjBxsgF-hFdAXXj0A9ghsZFzZLbZfVQ4uoGZ_kqw6xk9eoRr7OqWWdJy3Ba3a2r-3LZ4LzEizqxsynylL3mmhVJm1clfsjbDCelvUutsmHn5ZrVdyxZ5EXePuK2wukr2nxGHzqxNerL5bxG9zesTTOnqFZ5mhSOpL43OtIPZRBRULQD8CDaUBL5nooEjWknRCylDcoNusiLAcJQej4JAZSwr4mgglyj75P3qA_PJ2VGvuuNVNut2KvDyfCIEBIF1LXgjwmU-mCMVh0_6n4n9F8OLj93zG3HHAi3HVv428V6-rVTm3_opVQLLCdgMKP4rd4AocdebhUfjk8GYh_OQjIN631byyehudpbDZ00ylb0p1eaG9mrvVSbXis58s2h_9_3XgDzJJaS</recordid><startdate>19630101</startdate><enddate>19630101</enddate><creator>YOSHIDA, HIROSHI</creator><creator>FUJISAWA, HISAO</creator><creator>KAJIKAWA, KOZO</creator><general>The Japanese Pharmacological Society</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19630101</creationdate><title>BREAKDOWN OF HIGH ENERGY PHOSPHATE COMPOUNDS IN BRAIN SLICES IN RELATION WITH AN INCREASE IN PERMEABILITY TO CATIONS</title><author>YOSHIDA, HIROSHI ; FUJISAWA, HISAO ; KAJIKAWA, KOZO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-c57c6841e4f11218d43852e8a494faa9cc2e8e06f8291177c253711ea4523a4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Animals</topic><topic>Calcium</topic><topic>Calcium, Dietary</topic><topic>Cations</topic><topic>Cerebral Cortex</topic><topic>Cocaine</topic><topic>Coenzymes</topic><topic>Dinitrophenols</topic><topic>Edetic Acid</topic><topic>Guinea Pigs</topic><topic>Magnesium</topic><topic>Metabolism</topic><topic>Old Medline</topic><topic>Ouabain</topic><topic>Permeability</topic><topic>Pharmacology</topic><topic>Phosphates</topic><topic>Strophanthins</topic><topic>Veratrum</topic><toplevel>online_resources</toplevel><creatorcontrib>YOSHIDA, HIROSHI</creatorcontrib><creatorcontrib>FUJISAWA, HISAO</creatorcontrib><creatorcontrib>KAJIKAWA, KOZO</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YOSHIDA, HIROSHI</au><au>FUJISAWA, HISAO</au><au>KAJIKAWA, KOZO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BREAKDOWN OF HIGH ENERGY PHOSPHATE COMPOUNDS IN BRAIN SLICES IN RELATION WITH AN INCREASE IN PERMEABILITY TO CATIONS</atitle><jtitle>Japanese journal of pharmacology</jtitle><addtitle>Jpn.J.Pharmacol.</addtitle><date>1963-01-01</date><risdate>1963</risdate><volume>13</volume><issue>3</issue><spage>297</spage><epage>304</epage><pages>297-304</pages><issn>0021-5198</issn><eissn>1347-3506</eissn><abstract>It was shown in our previous paper (1) that protoveratrine and EDTA caused a remarkable increase in passive permeability of the membrane of brain slices to cations and this increase was completely prevented by so-called stabilizers such as cocaine and calcium ion. 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| issn | 0021-5198 1347-3506 |
| language | eng |
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| source | MEDLINE; J-STAGE日本語サイト (Free Access); Free Full-Text Journals in Chemistry; EZB Electronic Journals Library |
| subjects | Animals Calcium Calcium, Dietary Cations Cerebral Cortex Cocaine Coenzymes Dinitrophenols Edetic Acid Guinea Pigs Magnesium Metabolism Old Medline Ouabain Permeability Pharmacology Phosphates Strophanthins Veratrum |
| title | BREAKDOWN OF HIGH ENERGY PHOSPHATE COMPOUNDS IN BRAIN SLICES IN RELATION WITH AN INCREASE IN PERMEABILITY TO CATIONS |
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