Dengue virus replication enhancement in peripheral blood leukocytes from immune human beings
Dengue 2 virus replication in peripheral blood leukocyte cultures from 10 of 13 Asian or Polynesian subjects with actively acquired dengue immunity and two of three infants with passively acquired dengue antibody. Only 2 of 11 cultures from nonimmune infants or children supported viral replication....
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1976-01, Vol.151 (1), p.136-139 |
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| container_end_page | 139 |
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| container_issue | 1 |
| container_start_page | 136 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 151 |
| creator | Halstead, S B Marchette, N J Sung Chow, J S Lolekha, S |
| description | Dengue 2 virus replication in peripheral blood leukocyte cultures from 10 of 13 Asian or Polynesian subjects with actively acquired dengue immunity and two of three infants with passively acquired dengue antibody. Only 2 of 11 cultures from nonimmune infants or children supported viral replication. This study establishes a parallel in the biological behavior of human and simian PBL with respect to the immunological dependence of dengue virus replication in vitro. Elucidation of the mechanism (or mechamisms) regulating growth of dengue virus in leukocytes from immune hosts may contribute to an understanding of the role that virus-leukocyte interactions play in the pathogenesis of human dengue illness. |
| doi_str_mv | 10.3181/00379727-151-39160 |
| format | Article |
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Only 2 of 11 cultures from nonimmune infants or children supported viral replication. This study establishes a parallel in the biological behavior of human and simian PBL with respect to the immunological dependence of dengue virus replication in vitro. 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Only 2 of 11 cultures from nonimmune infants or children supported viral replication. This study establishes a parallel in the biological behavior of human and simian PBL with respect to the immunological dependence of dengue virus replication in vitro. Elucidation of the mechanism (or mechamisms) regulating growth of dengue virus in leukocytes from immune hosts may contribute to an understanding of the role that virus-leukocyte interactions play in the pathogenesis of human dengue illness.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies, Viral - analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dengue Virus - growth & development</subject><subject>Dengue Virus - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Leukocytes - microbiology</subject><subject>Male</subject><subject>Virus Replication</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtOwzAYRi0EKqXwAkhIntgCvtSJPSLuUiWWjkiR4_xpDbEd7Bipb09Li5i-5XxnOAhdUnLDqaS3hPBKVawqqKAFV7QkR2hKBRcFL5U6RtMdUOyIU3SW0gchpCSMTNCEMkEkV1P0_gB-lQF_25gTjjD01ujRBo_Br7U34MCP2Ho8QLTDGqLucdOH0OIe8mcwmxES7mJw2DqXPeB1dtrjBqxfpXN00uk-wcVhZ2j59Li8fykWb8-v93eLwjAlx0ICZ6SVpm3njDRV22hqFMxp2WjJqtawRhkuKgGEMaopVVQQLjgoURnoOj5D13vtEMNXhjTWziYDfa89hJxqyTkXQootyPagiSGlCF09ROt03NSU1Lui9V_Relu0_i26PV0d7Llx0P5f9gn5D8Z3ck0</recordid><startdate>197601</startdate><enddate>197601</enddate><creator>Halstead, S B</creator><creator>Marchette, N J</creator><creator>Sung Chow, J S</creator><creator>Lolekha, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197601</creationdate><title>Dengue virus replication enhancement in peripheral blood leukocytes from immune human beings</title><author>Halstead, S B ; Marchette, N J ; Sung Chow, J S ; Lolekha, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c298t-8e320d8cdd420b7dba1c9e416ba827dc2b9c3575e0221a119150353e957ceff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies, Viral - analysis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dengue Virus - growth & development</topic><topic>Dengue Virus - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Leukocytes - microbiology</topic><topic>Male</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Halstead, S B</creatorcontrib><creatorcontrib>Marchette, N J</creatorcontrib><creatorcontrib>Sung Chow, J S</creatorcontrib><creatorcontrib>Lolekha, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Halstead, S B</au><au>Marchette, N J</au><au>Sung Chow, J S</au><au>Lolekha, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dengue virus replication enhancement in peripheral blood leukocytes from immune human beings</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1976-01</date><risdate>1976</risdate><volume>151</volume><issue>1</issue><spage>136</spage><epage>139</epage><pages>136-139</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Dengue 2 virus replication in peripheral blood leukocyte cultures from 10 of 13 Asian or Polynesian subjects with actively acquired dengue immunity and two of three infants with passively acquired dengue antibody. 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| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1976-01, Vol.151 (1), p.136-139 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83335585 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Antibodies, Viral - analysis Child Child, Preschool Dengue Virus - growth & development Dengue Virus - immunology Female Humans Leukocytes - microbiology Male Virus Replication |
| title | Dengue virus replication enhancement in peripheral blood leukocytes from immune human beings |
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