Creatine phosphokinase in normal sheep and in sheep with nutritional muscular dystrophy
The distribution of CPK activity in the tissues of sheep was compared with that in the tissues of the ox, horse, pig and rat. The CPK activities found using the sensitive backward reaction in the presence of glutathione were much higher than those reported previously using less sensitive methods. It...
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| Veröffentlicht in: | Journal of comparative pathology 1976, Vol.86 (1), p.23-28 |
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| container_title | Journal of comparative pathology |
| container_volume | 86 |
| creator | Boyd, J.W. |
| description | The distribution of CPK activity in the tissues of sheep was compared with that in the tissues of the ox, horse, pig and rat. The CPK activities found using the sensitive backward reaction in the presence of glutathione were much higher than those reported previously using less sensitive methods. It was confirmed that CPK activity is highest in skeletal muscle. The concentration of CPK activity in cardiac muscle was 13 to 56 per cent. and in the cerebrum was 5 to 11 per cent. of that in skeletal muscle in the species examined.
The normal plasma activity of CPK in the pig was higher than in the sheep, ox and horse. In lambs with nutritional muscular dystrophy, plasma CPK was increased more than AspAT. Activities of both enzymes declined to normal after treatment with vitamin E or selenium, but the rate of decline of plasma CPK was more rapid. |
| doi_str_mv | 10.1016/0021-9975(76)90023-2 |
| format | Article |
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The normal plasma activity of CPK in the pig was higher than in the sheep, ox and horse. In lambs with nutritional muscular dystrophy, plasma CPK was increased more than AspAT. Activities of both enzymes declined to normal after treatment with vitamin E or selenium, but the rate of decline of plasma CPK was more rapid.</description><identifier>ISSN: 0021-9975</identifier><identifier>EISSN: 1532-3129</identifier><identifier>DOI: 10.1016/0021-9975(76)90023-2</identifier><identifier>PMID: 1254743</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>animal diseases ; animal health ; Animals ; Aspartate Aminotransferases - blood ; Cattle - metabolism ; Creatine Kinase - blood ; Creatine Kinase - metabolism ; Horses - metabolism ; Muscular Dystrophy, Animal - enzymology ; noninfectious diseases ; Rats - metabolism ; Selenium - deficiency ; Sheep - metabolism ; Sheep Diseases - enzymology ; Swine - metabolism ; Vitamin E Deficiency - enzymology ; Vitamin E Deficiency - veterinary</subject><ispartof>Journal of comparative pathology, 1976, Vol.86 (1), p.23-28</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-43ec94db45051a967f57c77486285f235a1aac11c4fedce3c81e6457a5fe03f43</citedby><cites>FETCH-LOGICAL-c381t-43ec94db45051a967f57c77486285f235a1aac11c4fedce3c81e6457a5fe03f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0021997576900232$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1254743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boyd, J.W.</creatorcontrib><title>Creatine phosphokinase in normal sheep and in sheep with nutritional muscular dystrophy</title><title>Journal of comparative pathology</title><addtitle>J Comp Pathol</addtitle><description>The distribution of CPK activity in the tissues of sheep was compared with that in the tissues of the ox, horse, pig and rat. The CPK activities found using the sensitive backward reaction in the presence of glutathione were much higher than those reported previously using less sensitive methods. It was confirmed that CPK activity is highest in skeletal muscle. The concentration of CPK activity in cardiac muscle was 13 to 56 per cent. and in the cerebrum was 5 to 11 per cent. of that in skeletal muscle in the species examined.
The normal plasma activity of CPK in the pig was higher than in the sheep, ox and horse. In lambs with nutritional muscular dystrophy, plasma CPK was increased more than AspAT. Activities of both enzymes declined to normal after treatment with vitamin E or selenium, but the rate of decline of plasma CPK was more rapid.</description><subject>animal diseases</subject><subject>animal health</subject><subject>Animals</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Cattle - metabolism</subject><subject>Creatine Kinase - blood</subject><subject>Creatine Kinase - metabolism</subject><subject>Horses - metabolism</subject><subject>Muscular Dystrophy, Animal - enzymology</subject><subject>noninfectious diseases</subject><subject>Rats - metabolism</subject><subject>Selenium - deficiency</subject><subject>Sheep - metabolism</subject><subject>Sheep Diseases - enzymology</subject><subject>Swine - metabolism</subject><subject>Vitamin E Deficiency - enzymology</subject><subject>Vitamin E Deficiency - veterinary</subject><issn>0021-9975</issn><issn>1532-3129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAQgC1ERRfaf9CKnCp6CPX4EScXpGpFW6SVegDUo2WcSdeQ2MFOQPvvSQiCGwfLmplvHvoI-QL0FCgUPyhlkFeVkieq-F5NEc_ZHlmB5CznwKp9snpFPpLDlG4ppWUp2QE5ACaFEnxF_q0jmsF5zPptSNO7c94kzJzPfIidabO0Rewz4-s5twSPbthmfhyiG1zwE9ONyY6tiVm9S0MM_Xb3iXxoTJvw88t_RK5_nV-t_-Sbv78v1j83ueUlDLngaCtR3whJJZiqUI1UVilRFqyUDePSgDEWwIoGa4vcloCFkMrIBilvBD8i35a5fQz3I6ZBdy5ZbFvjMYxJl5wzqSo6gWIBbQwpRWx0H11n4k4D1bNPPcvSsyytCv3sU7Op7evL_PGmw_qtaRE41Y-XemOCNv-jS_r6klHglFMAoPPis4XAScODw6iTdegt1i6iHXQd3PsnPAF07I54</recordid><startdate>1976</startdate><enddate>1976</enddate><creator>Boyd, J.W.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1976</creationdate><title>Creatine phosphokinase in normal sheep and in sheep with nutritional muscular dystrophy</title><author>Boyd, J.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-43ec94db45051a967f57c77486285f235a1aac11c4fedce3c81e6457a5fe03f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>animal diseases</topic><topic>animal health</topic><topic>Animals</topic><topic>Aspartate Aminotransferases - blood</topic><topic>Cattle - metabolism</topic><topic>Creatine Kinase - blood</topic><topic>Creatine Kinase - metabolism</topic><topic>Horses - metabolism</topic><topic>Muscular Dystrophy, Animal - enzymology</topic><topic>noninfectious diseases</topic><topic>Rats - metabolism</topic><topic>Selenium - deficiency</topic><topic>Sheep - metabolism</topic><topic>Sheep Diseases - enzymology</topic><topic>Swine - metabolism</topic><topic>Vitamin E Deficiency - enzymology</topic><topic>Vitamin E Deficiency - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boyd, J.W.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of comparative pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boyd, J.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Creatine phosphokinase in normal sheep and in sheep with nutritional muscular dystrophy</atitle><jtitle>Journal of comparative pathology</jtitle><addtitle>J Comp Pathol</addtitle><date>1976</date><risdate>1976</risdate><volume>86</volume><issue>1</issue><spage>23</spage><epage>28</epage><pages>23-28</pages><issn>0021-9975</issn><eissn>1532-3129</eissn><abstract>The distribution of CPK activity in the tissues of sheep was compared with that in the tissues of the ox, horse, pig and rat. The CPK activities found using the sensitive backward reaction in the presence of glutathione were much higher than those reported previously using less sensitive methods. It was confirmed that CPK activity is highest in skeletal muscle. The concentration of CPK activity in cardiac muscle was 13 to 56 per cent. and in the cerebrum was 5 to 11 per cent. of that in skeletal muscle in the species examined.
The normal plasma activity of CPK in the pig was higher than in the sheep, ox and horse. In lambs with nutritional muscular dystrophy, plasma CPK was increased more than AspAT. Activities of both enzymes declined to normal after treatment with vitamin E or selenium, but the rate of decline of plasma CPK was more rapid.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>1254743</pmid><doi>10.1016/0021-9975(76)90023-2</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0021-9975 |
| ispartof | Journal of comparative pathology, 1976, Vol.86 (1), p.23-28 |
| issn | 0021-9975 1532-3129 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | animal diseases animal health Animals Aspartate Aminotransferases - blood Cattle - metabolism Creatine Kinase - blood Creatine Kinase - metabolism Horses - metabolism Muscular Dystrophy, Animal - enzymology noninfectious diseases Rats - metabolism Selenium - deficiency Sheep - metabolism Sheep Diseases - enzymology Swine - metabolism Vitamin E Deficiency - enzymology Vitamin E Deficiency - veterinary |
| title | Creatine phosphokinase in normal sheep and in sheep with nutritional muscular dystrophy |
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