Physics of Tablet Compression XIII: Development of Die-Wall Pressure During Compression of Various Materials

Physics of Tablet Compression XIII: Development of Die-Wall Pressure During Compression of Various Materials

A method for determining the pressure transmitted to the die wall during tablet compression is described. Basically, the method involves strain-gauge measurement of die expansion and the relation of this to the transmitted pressure. The pressure transmitting behavior of a number of compounds, both o...

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Veröffentlicht in:Journal of pharmaceutical sciences 1963-08, Vol.52 (8), p.767-772
Hauptverfasser: Windheuser, John J., Misra, Jagdish, Eriksen, Stuart P., Higuchi, Takeru
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Sprache:eng
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Atmospheric Pressure
Old Medline
Physics
Pressure
Tablets
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container_end_page 772
container_issue 8
container_start_page 767
container_title Journal of pharmaceutical sciences
container_volume 52
creator Windheuser, John J.
Misra, Jagdish
Eriksen, Stuart P.
Higuchi, Takeru
description A method for determining the pressure transmitted to the die wall during tablet compression is described. Basically, the method involves strain-gauge measurement of die expansion and the relation of this to the transmitted pressure. The pressure transmitting behavior of a number of compounds, both organic and inorganic, have been studied; some correlations between observed response and physical properties are suggested. Limited studies on the effect of the addition of a lubricant to the crystals are also reported. It was noted that change in the magnitude of transmission to the die wall was not a simple linear function of lubricant concentration.
doi_str_mv 10.1002/jps.2600520812
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection
subjects Atmospheric Pressure
Old Medline
Physics
Pressure
Tablets
title Physics of Tablet Compression XIII: Development of Die-Wall Pressure During Compression of Various Materials
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