Enzymatic Investigations of Partially Purified Hog Kallikrein
KALLIKREIN, discovered by Frey in 1925 1 , was observed to be a hypotensive agent. Later work by many investigators has led to the present hypothesis that kallikrein is an enzyme, formed from a precursor kallikreininoken, which acts on protein substrates to liberate the biologically active polypepti...
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| Veröffentlicht in: | Nature (London) 1963-03, Vol.197 (4874), p.1300-1301 |
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| creator | CHAMBERS, D. A BOSSER, C GREEP, J. M NARDI, G. L |
| description | KALLIKREIN, discovered by Frey in 1925
1
, was observed to be a hypotensive agent. Later work by many investigators has led to the present hypothesis that kallikrein is an enzyme, formed from a precursor kallikreininoken, which acts on protein substrates to liberate the biologically active polypeptides, substance
P
, kallidin II, and bradykinin. It is these substances which manifest the hypotensive activity
2,3
. Because trypsin possesses the same ability to release active polypeptides, it becomes important for future investigations to differentiate clearly the two enzymes, trypsin and kallikrein. |
| doi_str_mv | 10.1038/1971300a0 |
| format | Article |
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1
, was observed to be a hypotensive agent. Later work by many investigators has led to the present hypothesis that kallikrein is an enzyme, formed from a precursor kallikreininoken, which acts on protein substrates to liberate the biologically active polypeptides, substance
P
, kallidin II, and bradykinin. It is these substances which manifest the hypotensive activity
2,3
. Because trypsin possesses the same ability to release active polypeptides, it becomes important for future investigations to differentiate clearly the two enzymes, trypsin and kallikrein.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/1971300a0</identifier><identifier>PMID: 14019949</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Humanities and Social Sciences ; Kallikreins ; letter ; multidisciplinary ; Old Medline ; Science ; Science (multidisciplinary) ; Trypsin</subject><ispartof>Nature (London), 1963-03, Vol.197 (4874), p.1300-1301</ispartof><rights>Springer Nature Limited 1963</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-f8c3ee93d32afc58291a7427d55bce0b08c77b0e87858ead4f91d5e57ef524a93</citedby><cites>FETCH-LOGICAL-c342t-f8c3ee93d32afc58291a7427d55bce0b08c77b0e87858ead4f91d5e57ef524a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/1971300a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/1971300a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14019949$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHAMBERS, D. A</creatorcontrib><creatorcontrib>BOSSER, C</creatorcontrib><creatorcontrib>GREEP, J. M</creatorcontrib><creatorcontrib>NARDI, G. L</creatorcontrib><title>Enzymatic Investigations of Partially Purified Hog Kallikrein</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>KALLIKREIN, discovered by Frey in 1925
1
, was observed to be a hypotensive agent. Later work by many investigators has led to the present hypothesis that kallikrein is an enzyme, formed from a precursor kallikreininoken, which acts on protein substrates to liberate the biologically active polypeptides, substance
P
, kallidin II, and bradykinin. It is these substances which manifest the hypotensive activity
2,3
. Because trypsin possesses the same ability to release active polypeptides, it becomes important for future investigations to differentiate clearly the two enzymes, trypsin and kallikrein.</description><subject>Humanities and Social Sciences</subject><subject>Kallikreins</subject><subject>letter</subject><subject>multidisciplinary</subject><subject>Old Medline</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Trypsin</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFLwzAUx4Mobk4PfgHtSVCoJk3SJAcPMqYbDtxBzyVNX0dm186kFeanN9KxXTw93ns_frz3R-iS4HuCqXwgShCKscZHaEiYSGOWSnGMhhgnMsaSpgN05v0KY8yJYKdoQBgmSjE1RI-T-me71q010az-Bt_aZWia2kdNGS20a62uqm206JwtLRTRtFlGr2FkPx3Y-hydlLrycLGrI_TxPHkfT-P528ts_DSPDWVJG5fSUABFC5ro0nCZKKIFS0TBeW4A51gaIXIMUkguQResVKTgwAWUPGFa0RG66b0b13x14cpsbb2BqtI1NJ3PJE0UTxMZwNseNK7x3kGZbZxda7fNCM7-ssr2WQX2aift8jUUB3IXTgDuesCHVb0El62aztXh0X9t1z1c67ZzcLDtiV-ekXtJ</recordid><startdate>19630330</startdate><enddate>19630330</enddate><creator>CHAMBERS, D. A</creator><creator>BOSSER, C</creator><creator>GREEP, J. M</creator><creator>NARDI, G. L</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19630330</creationdate><title>Enzymatic Investigations of Partially Purified Hog Kallikrein</title><author>CHAMBERS, D. A ; BOSSER, C ; GREEP, J. M ; NARDI, G. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-f8c3ee93d32afc58291a7427d55bce0b08c77b0e87858ead4f91d5e57ef524a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Humanities and Social Sciences</topic><topic>Kallikreins</topic><topic>letter</topic><topic>multidisciplinary</topic><topic>Old Medline</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Trypsin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHAMBERS, D. A</creatorcontrib><creatorcontrib>BOSSER, C</creatorcontrib><creatorcontrib>GREEP, J. M</creatorcontrib><creatorcontrib>NARDI, G. L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHAMBERS, D. A</au><au>BOSSER, C</au><au>GREEP, J. M</au><au>NARDI, G. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enzymatic Investigations of Partially Purified Hog Kallikrein</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1963-03-30</date><risdate>1963</risdate><volume>197</volume><issue>4874</issue><spage>1300</spage><epage>1301</epage><pages>1300-1301</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>KALLIKREIN, discovered by Frey in 1925
1
, was observed to be a hypotensive agent. Later work by many investigators has led to the present hypothesis that kallikrein is an enzyme, formed from a precursor kallikreininoken, which acts on protein substrates to liberate the biologically active polypeptides, substance
P
, kallidin II, and bradykinin. It is these substances which manifest the hypotensive activity
2,3
. Because trypsin possesses the same ability to release active polypeptides, it becomes important for future investigations to differentiate clearly the two enzymes, trypsin and kallikrein.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>14019949</pmid><doi>10.1038/1971300a0</doi><tpages>2</tpages></addata></record> |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Humanities and Social Sciences Kallikreins letter multidisciplinary Old Medline Science Science (multidisciplinary) Trypsin |
| title | Enzymatic Investigations of Partially Purified Hog Kallikrein |
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