Intranuclear Inclusions in Multiple Myeloma and Macroglobulinemia
Inclusion bodies in plasma cell nuclei of six patients with multiple myeloma and of three patients with macroglobulinemia have been studied histochemically. In three cases they have been studied with the electron microscope. The inclusions are readily identified in Giemsa stained smears of bone marr...
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| Veröffentlicht in: | Blood 1963-03, Vol.21 (3), p.335-351 |
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| creator | M. BRITTIN, GEOFFREY TANAKA, YASUKAZU BRECHER, GEORGE |
| description | Inclusion bodies in plasma cell nuclei of six patients with multiple myeloma and of three patients with macroglobulinemia have been studied histochemically. In three cases they have been studied with the electron microscope. The inclusions are readily identified in Giemsa stained smears of bone marrow and in paraffin sections. Their PAS positivity may be related to the hexose content of the patient's abnormal serum protein. Evidence is presented that the inclusions are true nuclear inclusion bodies, that they represent nuclear elaboration of glycoprotein, and that they may be found in all three immunoelectrophoretic varieties of multiple myeloma, as well as in macroglobulinemia. |
| doi_str_mv | 10.1182/blood.V21.3.335.335 |
| format | Article |
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BRITTIN, GEOFFREY</creatorcontrib><creatorcontrib>TANAKA, YASUKAZU</creatorcontrib><creatorcontrib>BRECHER, GEORGE</creatorcontrib><title>Intranuclear Inclusions in Multiple Myeloma and Macroglobulinemia</title><title>Blood</title><addtitle>Blood</addtitle><description>Inclusion bodies in plasma cell nuclei of six patients with multiple myeloma and of three patients with macroglobulinemia have been studied histochemically. In three cases they have been studied with the electron microscope. The inclusions are readily identified in Giemsa stained smears of bone marrow and in paraffin sections. Their PAS positivity may be related to the hexose content of the patient's abnormal serum protein. Evidence is presented that the inclusions are true nuclear inclusion bodies, that they represent nuclear elaboration of glycoprotein, and that they may be found in all three immunoelectrophoretic varieties of multiple myeloma, as well as in macroglobulinemia.</description><subject>Cell Nucleus</subject><subject>Humans</subject><subject>Intranuclear Inclusion Bodies</subject><subject>Multiple Myeloma</subject><subject>Old Medline</subject><subject>Plasma Cells</subject><subject>Waldenstrom Macroglobulinemia</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMotlZ_gSCzcjdjnvNYuCjFR6HFjboNmeRWIpmkJjNC_71TW3Dn4nI355x77ofQNcEFITW9a10IpninpGAFY2I_J2hKBK1zjCk-RVOMcZnzpiITdJHSJ8aEMyrO0YRwTIQo6RTNl76Pyg_agYrZ0ms3JBt8yqzP1oPr7dZBtt6BC53KlDfZWukYPlxoB2c9dFZdorONcgmujnuG3h4fXhfP-erlabmYr3LNy7LPFWgsGmB1JRQGLFTLtS7HsgzrujW6VZTSBqCmpqy4Ehw4VMSQitSm1kywGbo95G5j-Bog9bKzSYNzykMYkqwZbbgom1HIDsKxaEoRNnIbbafiThIs9-TkLzk5kpNMjtT2M7pujvFD24H58xxRjYL7gwDGJ78tRJm0Ba_B2Ai6lybYfw_8APuwgEs</recordid><startdate>196303</startdate><enddate>196303</enddate><creator>M. BRITTIN, GEOFFREY</creator><creator>TANAKA, YASUKAZU</creator><creator>BRECHER, GEORGE</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196303</creationdate><title>Intranuclear Inclusions in Multiple Myeloma and Macroglobulinemia</title><author>M. BRITTIN, GEOFFREY ; TANAKA, YASUKAZU ; BRECHER, GEORGE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-aec059e3875a0e05ab4cc652830c8bdcba2229ee82d674a54e4e71d1718d8c353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Cell Nucleus</topic><topic>Humans</topic><topic>Intranuclear Inclusion Bodies</topic><topic>Multiple Myeloma</topic><topic>Old Medline</topic><topic>Plasma Cells</topic><topic>Waldenstrom Macroglobulinemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>M. BRITTIN, GEOFFREY</creatorcontrib><creatorcontrib>TANAKA, YASUKAZU</creatorcontrib><creatorcontrib>BRECHER, GEORGE</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>M. BRITTIN, GEOFFREY</au><au>TANAKA, YASUKAZU</au><au>BRECHER, GEORGE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intranuclear Inclusions in Multiple Myeloma and Macroglobulinemia</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1963-03</date><risdate>1963</risdate><volume>21</volume><issue>3</issue><spage>335</spage><epage>351</epage><pages>335-351</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Inclusion bodies in plasma cell nuclei of six patients with multiple myeloma and of three patients with macroglobulinemia have been studied histochemically. In three cases they have been studied with the electron microscope. The inclusions are readily identified in Giemsa stained smears of bone marrow and in paraffin sections. Their PAS positivity may be related to the hexose content of the patient's abnormal serum protein. 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| ispartof | Blood, 1963-03, Vol.21 (3), p.335-351 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Cell Nucleus Humans Intranuclear Inclusion Bodies Multiple Myeloma Old Medline Plasma Cells Waldenstrom Macroglobulinemia |
| title | Intranuclear Inclusions in Multiple Myeloma and Macroglobulinemia |
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