Comparative studies of sheep immunoglobulins IgG1 and IgG2: Amino acid sequence of carboxy‐terminal cyanogen bromide fragments from their heavy chains
Sheep immunoglobulin IgG1 and immunoglobulin IgG2 heavy chains were treated with cyanogen bromide. The fractions from the C‐terminal end of the heavy chains were isolated and purified, and the amino acid sequences of these fractions were determined. The C‐terminal octadecapeptides from γ1 and γ2 hea...
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| Veröffentlicht in: | European journal of immunology 1975-04, Vol.5 (4), p.291-293 |
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| container_title | European journal of immunology |
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| creator | Conde, F. P. Deverson, E. V. Milstein, Celia P. |
| description | Sheep immunoglobulin IgG1 and immunoglobulin IgG2 heavy chains were treated with cyanogen bromide. The fractions from the C‐terminal end of the heavy chains were isolated and purified, and the amino acid sequences of these fractions were determined. The C‐terminal octadecapeptides from γ1 and γ2 heavy chains had the identical sequence: Met‐His‐Glx‐Ala‐Leu‐His‐Asx‐His‐Tyr‐Thr‐Glx‐Lys‐Ser‐Ile‐Ser‐Lys‐Pro‐Pro‐Gly.
Comparison with the C‐terminal peptides of other species, reported in the literature, suggests that the subclasses are the results of recent evolutionary processes. Residues at position 4 from the C‐terminus may be phylogenetically related. |
| doi_str_mv | 10.1002/eji.1830050416 |
| format | Article |
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Comparison with the C‐terminal peptides of other species, reported in the literature, suggests that the subclasses are the results of recent evolutionary processes. Residues at position 4 from the C‐terminus may be phylogenetically related.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830050416</identifier><identifier>PMID: 824134</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Amino Acid Sequence ; Animals ; Cyanogen Bromide ; Immunoglobulin Allotypes ; Immunoglobulin G - analysis ; Immunoglobulin gamma-Chains - analysis ; Immunoglobulin Heavy Chains - analysis ; Sheep - immunology</subject><ispartof>European journal of immunology, 1975-04, Vol.5 (4), p.291-293</ispartof><rights>Copyright © 1975 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830050416$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830050416$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/824134$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conde, F. P.</creatorcontrib><creatorcontrib>Deverson, E. V.</creatorcontrib><creatorcontrib>Milstein, Celia P.</creatorcontrib><title>Comparative studies of sheep immunoglobulins IgG1 and IgG2: Amino acid sequence of carboxy‐terminal cyanogen bromide fragments from their heavy chains</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Sheep immunoglobulin IgG1 and immunoglobulin IgG2 heavy chains were treated with cyanogen bromide. The fractions from the C‐terminal end of the heavy chains were isolated and purified, and the amino acid sequences of these fractions were determined. The C‐terminal octadecapeptides from γ1 and γ2 heavy chains had the identical sequence: Met‐His‐Glx‐Ala‐Leu‐His‐Asx‐His‐Tyr‐Thr‐Glx‐Lys‐Ser‐Ile‐Ser‐Lys‐Pro‐Pro‐Gly.
Comparison with the C‐terminal peptides of other species, reported in the literature, suggests that the subclasses are the results of recent evolutionary processes. Residues at position 4 from the C‐terminus may be phylogenetically related.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Cyanogen Bromide</subject><subject>Immunoglobulin Allotypes</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin gamma-Chains - analysis</subject><subject>Immunoglobulin Heavy Chains - analysis</subject><subject>Sheep - immunology</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFUbtu3DAQJIIkzsVJ6yoFq3Ry-D7SnXHw4wwDaZJaoKi9OxqiqJCSHXX-BJf5vnyJeTjDrnYWM7uLnUHohJJTSgj7AXf-lGpOiCSCqndoQSWjlaCCvkcLQqiomNHkE_qc8x0hxChpjtBHzQTlYoH-rWIYbLKjvwecx6n1kHHc4LwDGLAPYerjtovN1Pk-4_X2imLbt3vAzvB58H3E1vkWZ_gzQe9gP-tsauLf-f_j0wipSGyH3WzLHuhxk2LwLeBNstsA_ZgLigGPO_AJ78Dez9jtbLn1BX3Y2C7D15d6jH5fXvxaXVe3P6_Wq_PbamBSqsqaDddqSTi0XGnStFo4IMCWS2DOSNY0xRnRGLlkyjrZGguEagnaKKO04PwYfT_sHVIsL-SxDj476DrbQ5xyrTnTWihThN9ehFMToK2H5INNc31wstDmQD_4DuZXlpJ6n1JdUqrfUqovbtZvHX8G5RCIyQ</recordid><startdate>197504</startdate><enddate>197504</enddate><creator>Conde, F. P.</creator><creator>Deverson, E. V.</creator><creator>Milstein, Celia P.</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197504</creationdate><title>Comparative studies of sheep immunoglobulins IgG1 and IgG2: Amino acid sequence of carboxy‐terminal cyanogen bromide fragments from their heavy chains</title><author>Conde, F. P. ; Deverson, E. V. ; Milstein, Celia P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2556-a9f386703ed3680bd84ce0e277e2c952bb3004b95726ac5d9ae0185e896968433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Cyanogen Bromide</topic><topic>Immunoglobulin Allotypes</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin gamma-Chains - analysis</topic><topic>Immunoglobulin Heavy Chains - analysis</topic><topic>Sheep - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conde, F. P.</creatorcontrib><creatorcontrib>Deverson, E. V.</creatorcontrib><creatorcontrib>Milstein, Celia P.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conde, F. P.</au><au>Deverson, E. V.</au><au>Milstein, Celia P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative studies of sheep immunoglobulins IgG1 and IgG2: Amino acid sequence of carboxy‐terminal cyanogen bromide fragments from their heavy chains</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1975-04</date><risdate>1975</risdate><volume>5</volume><issue>4</issue><spage>291</spage><epage>293</epage><pages>291-293</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>Sheep immunoglobulin IgG1 and immunoglobulin IgG2 heavy chains were treated with cyanogen bromide. The fractions from the C‐terminal end of the heavy chains were isolated and purified, and the amino acid sequences of these fractions were determined. The C‐terminal octadecapeptides from γ1 and γ2 heavy chains had the identical sequence: Met‐His‐Glx‐Ala‐Leu‐His‐Asx‐His‐Tyr‐Thr‐Glx‐Lys‐Ser‐Ile‐Ser‐Lys‐Pro‐Pro‐Gly.
Comparison with the C‐terminal peptides of other species, reported in the literature, suggests that the subclasses are the results of recent evolutionary processes. Residues at position 4 from the C‐terminus may be phylogenetically related.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>824134</pmid><doi>10.1002/eji.1830050416</doi><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Amino Acid Sequence Animals Cyanogen Bromide Immunoglobulin Allotypes Immunoglobulin G - analysis Immunoglobulin gamma-Chains - analysis Immunoglobulin Heavy Chains - analysis Sheep - immunology |
| title | Comparative studies of sheep immunoglobulins IgG1 and IgG2: Amino acid sequence of carboxy‐terminal cyanogen bromide fragments from their heavy chains |
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