The influence of L-methionine-D,L-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14C-leucine
Methionine sulfoximine (MSO) inhibits the labelling of the acid soluble fraction and proteins of the brain cortex after the injection of 14C-leucine. The inhibition takes place even during the early stages after the injection of MSO, when no symptoms of paroxysms are observable. The action of MSO on...
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| Veröffentlicht in: | Experimentelle Pathologie 1975, Vol.10 (3), p.211-215 |
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| container_title | Experimentelle Pathologie |
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| creator | Lisý, V. Lodin, Z. |
| description | Methionine sulfoximine (MSO) inhibits the labelling of the acid soluble fraction and proteins of the brain cortex after the injection of
14C-leucine. The inhibition takes place even during the early stages after the injection of MSO, when no symptoms of paroxysms are observable. The action of MSO on the labelling of the acid soluble fraction and proteins in the brain cortex is obviously different from that in the kidney and liver. Whereas in the brain tissue MSO markedly influences the labelling of the free amino acid pool, in the kidney and liver it seems primarily affect the protein synthetic mechanisms. Also no decrease in labelling of the plasma acid soluble fraction was found on mice, treated with MSO. Experimental data support the idea, that the changes in the metabolism of proteins in the brain are not connected with the onset of the paroxysmal period. |
| doi_str_mv | 10.1016/S0014-4908(75)80024-X |
| format | Article |
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14C-leucine. The inhibition takes place even during the early stages after the injection of MSO, when no symptoms of paroxysms are observable. The action of MSO on the labelling of the acid soluble fraction and proteins in the brain cortex is obviously different from that in the kidney and liver. Whereas in the brain tissue MSO markedly influences the labelling of the free amino acid pool, in the kidney and liver it seems primarily affect the protein synthetic mechanisms. Also no decrease in labelling of the plasma acid soluble fraction was found on mice, treated with MSO. Experimental data support the idea, that the changes in the metabolism of proteins in the brain are not connected with the onset of the paroxysmal period.</description><identifier>ISSN: 0014-4908</identifier><identifier>DOI: 10.1016/S0014-4908(75)80024-X</identifier><identifier>PMID: 1233283</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; brain ; Carbon Radioisotopes ; Cerebral Cortex - drug effects ; Cerebral Cortex - metabolism ; convulsions ; Injections, Intraperitoneal ; kidney ; L-methionine-D,L-sulfoximine ; Leucine - administration & dosage ; Leucine - pharmacology ; liver ; Male ; Methionine - pharmacology ; Mice ; mouse ; paroxysm ; protein metabolism ; Proteins - metabolism</subject><ispartof>Experimentelle Pathologie, 1975, Vol.10 (3), p.211-215</ispartof><rights>1975</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1553-b61da85642c2f51d3423c50e3cc0cd344a71fbd22113bff1da34b7ae4428c033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1233283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lisý, V.</creatorcontrib><creatorcontrib>Lodin, Z.</creatorcontrib><title>The influence of L-methionine-D,L-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14C-leucine</title><title>Experimentelle Pathologie</title><addtitle>Exp Pathol (Jena)</addtitle><description>Methionine sulfoximine (MSO) inhibits the labelling of the acid soluble fraction and proteins of the brain cortex after the injection of
14C-leucine. The inhibition takes place even during the early stages after the injection of MSO, when no symptoms of paroxysms are observable. The action of MSO on the labelling of the acid soluble fraction and proteins in the brain cortex is obviously different from that in the kidney and liver. Whereas in the brain tissue MSO markedly influences the labelling of the free amino acid pool, in the kidney and liver it seems primarily affect the protein synthetic mechanisms. Also no decrease in labelling of the plasma acid soluble fraction was found on mice, treated with MSO. Experimental data support the idea, that the changes in the metabolism of proteins in the brain are not connected with the onset of the paroxysmal period.</description><subject>Animals</subject><subject>brain</subject><subject>Carbon Radioisotopes</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - metabolism</subject><subject>convulsions</subject><subject>Injections, Intraperitoneal</subject><subject>kidney</subject><subject>L-methionine-D,L-sulfoximine</subject><subject>Leucine - administration & dosage</subject><subject>Leucine - pharmacology</subject><subject>liver</subject><subject>Male</subject><subject>Methionine - pharmacology</subject><subject>Mice</subject><subject>mouse</subject><subject>paroxysm</subject><subject>protein metabolism</subject><subject>Proteins - metabolism</subject><issn>0014-4908</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1vFSEUZVHTNrU_oQkro4konzPjypjnZ_KSLvoW3RGGuVgaBp7AmPqL_JsynUaXsiGXe8493HMQumL0DaOse3tDKZNEvqPDy169GijlktyeoPO_z2fospR72k7Hu4HTU3TKuBB8EOfo9-EOsI8uLBAt4OTwnsxQ73yKPgL5-HpPyhJcevBzq3GKuDZCMCOE4OP3lWCsn3BJYRkDYJeNrY2MTZzwMacKPpYVtdLGbHzENuUKD9i4CrlJ12yOkH1NEUxo9T1sAxqHyR0JsNim_Bw9cyYUuHy6L9Dh86fD7ivZX3_5tvuwJ5YpJcjYsckMqpPccqfYJCQXVlEQ1lLbKml65saJc8bE6FwDCzn2BqTkg6VCXKAX29j29R8LlKpnX2zb1URIS9FDc433QjWg2oA2p1IyOH3Mfjb5l2ZUr7Hox1j06r_ulX6MRd823tWTwDLOMP1jbYG0_vutD23Jnx6yLtav0Uw-N2P0lPx_FP4AuVehPg</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>Lisý, V.</creator><creator>Lodin, Z.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1975</creationdate><title>The influence of L-methionine-D,L-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14C-leucine</title><author>Lisý, V. ; Lodin, Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1553-b61da85642c2f51d3423c50e3cc0cd344a71fbd22113bff1da34b7ae4428c033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>brain</topic><topic>Carbon Radioisotopes</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - metabolism</topic><topic>convulsions</topic><topic>Injections, Intraperitoneal</topic><topic>kidney</topic><topic>L-methionine-D,L-sulfoximine</topic><topic>Leucine - administration & dosage</topic><topic>Leucine - pharmacology</topic><topic>liver</topic><topic>Male</topic><topic>Methionine - pharmacology</topic><topic>Mice</topic><topic>mouse</topic><topic>paroxysm</topic><topic>protein metabolism</topic><topic>Proteins - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Lisý, V.</creatorcontrib><creatorcontrib>Lodin, Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimentelle Pathologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lisý, V.</au><au>Lodin, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of L-methionine-D,L-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14C-leucine</atitle><jtitle>Experimentelle Pathologie</jtitle><addtitle>Exp Pathol (Jena)</addtitle><date>1975</date><risdate>1975</risdate><volume>10</volume><issue>3</issue><spage>211</spage><epage>215</epage><pages>211-215</pages><issn>0014-4908</issn><abstract>Methionine sulfoximine (MSO) inhibits the labelling of the acid soluble fraction and proteins of the brain cortex after the injection of
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| fulltext | fulltext |
| identifier | ISSN: 0014-4908 |
| ispartof | Experimentelle Pathologie, 1975, Vol.10 (3), p.211-215 |
| issn | 0014-4908 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals brain Carbon Radioisotopes Cerebral Cortex - drug effects Cerebral Cortex - metabolism convulsions Injections, Intraperitoneal kidney L-methionine-D,L-sulfoximine Leucine - administration & dosage Leucine - pharmacology liver Male Methionine - pharmacology Mice mouse paroxysm protein metabolism Proteins - metabolism |
| title | The influence of L-methionine-D,L-sulfoximine on the labelling of acid soluble fraction and proteins of the brain cortex after intraperitoneal injection of 14C-leucine |
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