The Influence Of Corticosteroids And Topical Indomethacin On Sunburn Erythema
The extent to which topical and intradermal corticosteroids and topical indomethacin suppress sunburn erythema was investigated in human volunteers. Both agents retarded the onset and decreased the magnitude of delayed erythema. Suppression by corticosteroids was not demonstrable with ultraviolet do...
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| Veröffentlicht in: | Journal of investigative dermatology 1976-03, Vol.66 (3), p.153-156 |
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| container_title | Journal of investigative dermatology |
| container_volume | 66 |
| creator | Kaidbey, Kays H. Kurban, Amal K. |
| description | The extent to which topical and intradermal corticosteroids and topical indomethacin suppress sunburn erythema was investigated in human volunteers. Both agents retarded the onset and decreased the magnitude of delayed erythema. Suppression by corticosteroids was not demonstrable with ultraviolet doses larger than 2 MEDs (minimal erythema dose). Below 2 MEDs, topical betamethasone valerate produced a dose-related suppression of erythema.
Indomethacin was more effective and produced a measurable dose-dependent suppression against 3 and 6 MEDs. Despite significant inhibition of erythema. Sunburn damage to epidermal cells was not altered by these drugs. |
| doi_str_mv | 10.1111/1523-1747.ep12481895 |
| format | Article |
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Indomethacin was more effective and produced a measurable dose-dependent suppression against 3 and 6 MEDs. Despite significant inhibition of erythema. Sunburn damage to epidermal cells was not altered by these drugs.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Betamethasone - analogs & derivatives</subject><subject>Betamethasone Valerate - administration & dosage</subject><subject>Betamethasone Valerate - therapeutic use</subject><subject>Humans</subject><subject>Indomethacin - administration & dosage</subject><subject>Indomethacin - therapeutic use</subject><subject>Injections, Intradermal</subject><subject>Sunburn - drug therapy</subject><subject>Triamcinolone - administration & dosage</subject><subject>Triamcinolone - therapeutic use</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMouq5-A4WevHXNv7bpRZBl1QVlD_bgLbTJhI20yZq0gt_ell3cm3MZmPfe8PghdEPwgoxzTzLKUlLwYgE7QrkgosxO0OzvfIpmGFOaUkw_LtBljJ8Yk5xn4hydj_6Scz5Db9UWkrUz7QBOQbIxydKH3iofewje6pg8Op1UfmdV3Y5G7Tvot7WyLtm45H1wzRBcsgo__Ra6-gqdmbqNcH3Yc1Q9rarlS_q6eV4vH19TxUvSp3nDuDZlQaEQAudNSZWmJsfQlAyYKDArMWhDa5wBF7kGbJgy2FDdYMFyNkd3-7e74L8GiL3sbFTQtrUDP0QpGC0YYWw08r1RBR9jACN3wXZ1-JEEywminGjJiZY8Qhxjt4f_Q9OBPob21I66q_shwJ-e5aTAxdTvYa_DyODbQpBR2YmvtgFUL7W3_xf4BQsTisQ</recordid><startdate>197603</startdate><enddate>197603</enddate><creator>Kaidbey, Kays H.</creator><creator>Kurban, Amal K.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197603</creationdate><title>The Influence Of Corticosteroids And Topical Indomethacin On Sunburn Erythema</title><author>Kaidbey, Kays H. ; Kurban, Amal K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-6b34df972e78806b92cd2f60eb93e3870390edf2a05e486de0f3cf0f2db08363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Betamethasone - analogs & derivatives</topic><topic>Betamethasone Valerate - administration & dosage</topic><topic>Betamethasone Valerate - therapeutic use</topic><topic>Humans</topic><topic>Indomethacin - administration & dosage</topic><topic>Indomethacin - therapeutic use</topic><topic>Injections, Intradermal</topic><topic>Sunburn - drug therapy</topic><topic>Triamcinolone - administration & dosage</topic><topic>Triamcinolone - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaidbey, Kays H.</creatorcontrib><creatorcontrib>Kurban, Amal K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaidbey, Kays H.</au><au>Kurban, Amal K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Influence Of Corticosteroids And Topical Indomethacin On Sunburn Erythema</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1976-03</date><risdate>1976</risdate><volume>66</volume><issue>3</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>The extent to which topical and intradermal corticosteroids and topical indomethacin suppress sunburn erythema was investigated in human volunteers. Both agents retarded the onset and decreased the magnitude of delayed erythema. Suppression by corticosteroids was not demonstrable with ultraviolet doses larger than 2 MEDs (minimal erythema dose). Below 2 MEDs, topical betamethasone valerate produced a dose-related suppression of erythema.
Indomethacin was more effective and produced a measurable dose-dependent suppression against 3 and 6 MEDs. Despite significant inhibition of erythema. Sunburn damage to epidermal cells was not altered by these drugs.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1249444</pmid><doi>10.1111/1523-1747.ep12481895</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-202X |
| ispartof | Journal of investigative dermatology, 1976-03, Vol.66 (3), p.153-156 |
| issn | 0022-202X 1523-1747 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83273133 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Administration, Topical Adult Betamethasone - analogs & derivatives Betamethasone Valerate - administration & dosage Betamethasone Valerate - therapeutic use Humans Indomethacin - administration & dosage Indomethacin - therapeutic use Injections, Intradermal Sunburn - drug therapy Triamcinolone - administration & dosage Triamcinolone - therapeutic use |
| title | The Influence Of Corticosteroids And Topical Indomethacin On Sunburn Erythema |
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