Effects of cytosine arabinoside, adenine arabinoside, and 6-azauridine on rabies virus in vitro and in vivo

The antiviral agents cytosine arabinoside, adenine arabinoside, and 6-azauridine were shown to inhibit the replication of rabies virus in vitro but not the replication of Sindbis virus. These same drugs were not effective in reducing the mortality rate in mice challenged with street rabies virus.

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infectious diseases 1976, Vol.133 (1), p.7-13
Hauptverfasser:	Harmon, M.W, Janis, B
Format:	Artikel
Sprache:	eng
Schlagworte:	animal diseases animal health Animals Antiviral Agents - pharmacology Antivirals Azauridine - pharmacology Cell Line Cytarabine - pharmacology Death Dose-Response Relationship, Drug Drug control Drug Evaluation, Preclinical In Vitro Techniques Infections Inoculation Major Articles Mice Mortality Purine Nucleosides - pharmacology Rabies Rabies - drug therapy Rabies virus Rabies virus - drug effects Sindbis Virus Vidarabine - pharmacology Viruses
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Beschreibung
Zusammenfassung:	The antiviral agents cytosine arabinoside, adenine arabinoside, and 6-azauridine were shown to inhibit the replication of rabies virus in vitro but not the replication of Sindbis virus. These same drugs were not effective in reducing the mortality rate in mice challenged with street rabies virus.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/133.1.7