Effect of aromatic nitro compounds on oxidative metabolism by cytochrome P-450 dependent enzymes

The effect of aromatic nitro compounds on the oxidative metabolism of representative type I (hexobarbital and aminopyrene) and type II (aniline and zoxazolamine) substrates by cytochrome P-450 dependent liver enzymes was studied. Nitro compounds (nitrobenzene, p-nitrobenzoate, 2-nitrofluorene, and 2...

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Veröffentlicht in:	Journal of medicinal chemistry 1976-01, Vol.19 (1), p.174-177
Hauptverfasser:	Sternson, Larry A, Gammans, Richard E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine - metabolism Aminopyrine - pharmacology Aniline Compounds - metabolism Aniline Compounds - pharmacology Aniline Hydroxylase - metabolism Animals Cytochrome P-450 Enzyme System - metabolism Energy Metabolism - drug effects Hexobarbital - metabolism Hexobarbital - pharmacology In Vitro Techniques Kinetics Male Microsomes, Liver - enzymology Microsomes, Liver - metabolism Mixed Function Oxygenases - metabolism Nitro Compounds - metabolism Nitro Compounds - pharmacology Oxidation-Reduction Rabbits Zoxazolamine - metabolism Zoxazolamine - pharmacology
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