FIVE YEARS' EXPERIENCE WITH THE EVALUATION OF DIURETIC AGENTS

Twelve diuretics and 2 combinations of diuretics were evaluated by a standard methodology. Electrolyte excretion patterns were evaluated in "normal" hospitalized patients, and acute weight loss was evaluated in out-patients in congestive failure. The large standard errors of the means for...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1963-12, Vol.28 (6), p.1042-1049
Hauptverfasser:	SWARTZ, C, SELLER, R, FUCHS, M, BREST, A N, MOYER, J H
Format:	Artikel
Sprache:	eng
Schlagworte:	Body Weight Body Weights and Measures Diuretics Heart Failure Natriuresis Old Medline Pharmacology Potassium Urine
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container_title	Circulation (New York, N.Y.)
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creator	SWARTZ, C SELLER, R FUCHS, M BREST, A N MOYER, J H
description	Twelve diuretics and 2 combinations of diuretics were evaluated by a standard methodology. Electrolyte excretion patterns were evaluated in "normal" hospitalized patients, and acute weight loss was evaluated in out-patients in congestive failure. The large standard errors of the means for natriuresis, kaluresis, and acute weight loss reflect the inherent biologic variation of such assays and permit separation of drugs into only a few overlapping categories of potency. The combination of a mercurial and a thiazide caused significantly greater sodium excretion than any other drug used alone. No single diuretic was significantly more potent than all others.
doi_str_mv	10.1161/01.CIR.28.6.1042
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source	MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals
subjects	Body Weight Body Weights and Measures Diuretics Heart Failure Natriuresis Old Medline Pharmacology Potassium Urine
title	FIVE YEARS' EXPERIENCE WITH THE EVALUATION OF DIURETIC AGENTS
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