Indomethacin induces rat uterine contractions in vitro and alters reactivity to calcium and acetylcholine
The initial contractions of uteri in vitro from castrated, estrogen-treated rats, were markedly diminished following replacement with fresh bathing medium. Indomethacin and aspirin (10−5 to 10−4M) strongly stimulated such quiescent preparations and reduced their subsequent responsiveness to Ca++. Re...
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| Veröffentlicht in: | Am. J. Obstet. Gynecol.; (United States) 1976-01, Vol.124 (1), p.25-29 |
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| container_title | Am. J. Obstet. Gynecol.; (United States) |
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| creator | Hargrove, J.L. Nesbitt, D. Gaspar, M.J. Ellis, L.C. |
| description | The initial contractions of uteri in vitro from castrated, estrogen-treated rats, were markedly diminished following replacement with fresh bathing medium. Indomethacin and aspirin (10−5 to 10−4M) strongly stimulated such quiescent preparations and reduced their subsequent responsiveness to Ca++. Reintroducing the initial bathing medium (which contained prostaglandin-like material), or adding prostaglandin F2α to the fresh medium, initiated uterine contractions and restored responsiveness to calcium ion. Injections of indomethacin into castrated, estrogen-treated rats reduced initial in vitro uterine motility, abolished production of prostaglandin-like compounds, and prevented either indomethacin, aspirin, or Ca++ from stimulating uterine contractions. Uterine responsiveness to acetylcholine in vitro was significantly reduced in rats pretreated with indomethacin. |
| doi_str_mv | 10.1016/0002-9378(76)90006-5 |
| format | Article |
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Indomethacin and aspirin (10−5 to 10−4M) strongly stimulated such quiescent preparations and reduced their subsequent responsiveness to Ca++. Reintroducing the initial bathing medium (which contained prostaglandin-like material), or adding prostaglandin F2α to the fresh medium, initiated uterine contractions and restored responsiveness to calcium ion. Injections of indomethacin into castrated, estrogen-treated rats reduced initial in vitro uterine motility, abolished production of prostaglandin-like compounds, and prevented either indomethacin, aspirin, or Ca++ from stimulating uterine contractions. Uterine responsiveness to acetylcholine in vitro was significantly reduced in rats pretreated with indomethacin.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(76)90006-5</identifier><identifier>PMID: 1244744</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>551000 - Physiological Systems ; ACETYLCHOLINE ; Acetylcholine - pharmacology ; ACETYLSALICYLIC ACID ; ALKALINE EARTH METALS ; AMINES ; AMMONIUM COMPOUNDS ; ANALGESICS ; ANIMALS ; BASIC BIOLOGICAL SCIENCES ; BIOLOGICAL EFFECTS ; BODY ; CALCIUM ; Calcium - pharmacology ; CARBOXYLIC ACIDS ; Dose-Response Relationship, Drug ; DRUGS ; ELEMENTS ; ESTERS ; ESTROGENS ; Female ; FEMALE GENITALS ; HORMONES ; HYDROXY ACIDS ; IN VITRO ; In Vitro Techniques ; Indomethacin - pharmacology ; MAMMALS ; METALS ; ORGANIC ACIDS ; ORGANIC COMPOUNDS ; ORGANS ; PARASYMPATHOMIMETICS ; PHYSIOLOGY ; Pregnancy ; PROSTAGLANDINS ; Prostaglandins - biosynthesis ; QUATERNARY COMPOUNDS ; RATS ; RODENTS ; STEROID HORMONES ; Uterine Contraction - drug effects ; UTERUS ; Uterus - metabolism ; VERTEBRATES</subject><ispartof>Am. 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Gynecol.; (United States), 1976-01, Vol.124 (1), p.25-29</ispartof><rights>1976</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c299t-769098b97439948162e3c7bac7d436c8c1a6b0577794a978f1dbedcc3332139c3</citedby><cites>FETCH-LOGICAL-c299t-769098b97439948162e3c7bac7d436c8c1a6b0577794a978f1dbedcc3332139c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937876900065$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1244744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/7313404$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Hargrove, J.L.</creatorcontrib><creatorcontrib>Nesbitt, D.</creatorcontrib><creatorcontrib>Gaspar, M.J.</creatorcontrib><creatorcontrib>Ellis, L.C.</creatorcontrib><creatorcontrib>Utah State Univ., Logan</creatorcontrib><title>Indomethacin induces rat uterine contractions in vitro and alters reactivity to calcium and acetylcholine</title><title>Am. J. Obstet. Gynecol.; (United States)</title><addtitle>Am J Obstet Gynecol</addtitle><description>The initial contractions of uteri in vitro from castrated, estrogen-treated rats, were markedly diminished following replacement with fresh bathing medium. Indomethacin and aspirin (10−5 to 10−4M) strongly stimulated such quiescent preparations and reduced their subsequent responsiveness to Ca++. Reintroducing the initial bathing medium (which contained prostaglandin-like material), or adding prostaglandin F2α to the fresh medium, initiated uterine contractions and restored responsiveness to calcium ion. Injections of indomethacin into castrated, estrogen-treated rats reduced initial in vitro uterine motility, abolished production of prostaglandin-like compounds, and prevented either indomethacin, aspirin, or Ca++ from stimulating uterine contractions. Uterine responsiveness to acetylcholine in vitro was significantly reduced in rats pretreated with indomethacin.</description><subject>551000 - Physiological Systems</subject><subject>ACETYLCHOLINE</subject><subject>Acetylcholine - pharmacology</subject><subject>ACETYLSALICYLIC ACID</subject><subject>ALKALINE EARTH METALS</subject><subject>AMINES</subject><subject>AMMONIUM COMPOUNDS</subject><subject>ANALGESICS</subject><subject>ANIMALS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BODY</subject><subject>CALCIUM</subject><subject>Calcium - pharmacology</subject><subject>CARBOXYLIC ACIDS</subject><subject>Dose-Response Relationship, Drug</subject><subject>DRUGS</subject><subject>ELEMENTS</subject><subject>ESTERS</subject><subject>ESTROGENS</subject><subject>Female</subject><subject>FEMALE GENITALS</subject><subject>HORMONES</subject><subject>HYDROXY ACIDS</subject><subject>IN VITRO</subject><subject>In Vitro Techniques</subject><subject>Indomethacin - pharmacology</subject><subject>MAMMALS</subject><subject>METALS</subject><subject>ORGANIC ACIDS</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANS</subject><subject>PARASYMPATHOMIMETICS</subject><subject>PHYSIOLOGY</subject><subject>Pregnancy</subject><subject>PROSTAGLANDINS</subject><subject>Prostaglandins - biosynthesis</subject><subject>QUATERNARY COMPOUNDS</subject><subject>RATS</subject><subject>RODENTS</subject><subject>STEROID HORMONES</subject><subject>Uterine Contraction - drug effects</subject><subject>UTERUS</subject><subject>Uterus - metabolism</subject><subject>VERTEBRATES</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1976</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9vFSEUxYmxqc_qN9CEuDC6mAoDD4ZNE9P4p0mTbnRNmMt9eZgZqMA0ed--jNPozhW5nN89XM4l5A1nl5xx9Ykx1ndG6OGDVh9Nq1S3f0Z2nBndqUENz8nuL_KCvCzl11r2pj8n57yXUku5I-Em-jRjPToIkYboF8BCs6t0qZhDRAop1uyghhRLA-hDqDlRFz11U0MajKvark-0JgpugrDMGwBYTxMc09SMXpGzg5sKvn46L8jPr19-XH_vbu--3Vx_vu2gN6Z2WhlmhtFoKYyRA1c9CtCjA-2lUDAAd2pke621kc7o4cD9iB5ACNFzYUBckHebbyo12AKhIhzbJyJCtVpwIZls0PsNus_p94Kl2jkUwGlyEdNS7CB6qfVgGig3EHIqJePB3ucwu3yynNl1DXYN1a4ZW63snzXYfWt7--S_jDP6f01b7k2_2nRsSTwEzOugGAF9yOucPoX_P_AIymuXXw</recordid><startdate>19760101</startdate><enddate>19760101</enddate><creator>Hargrove, J.L.</creator><creator>Nesbitt, D.</creator><creator>Gaspar, M.J.</creator><creator>Ellis, L.C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19760101</creationdate><title>Indomethacin induces rat uterine contractions in vitro and alters reactivity to calcium and acetylcholine</title><author>Hargrove, J.L. ; Nesbitt, D. ; Gaspar, M.J. ; Ellis, L.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-769098b97439948162e3c7bac7d436c8c1a6b0577794a978f1dbedcc3332139c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1976</creationdate><topic>551000 - Physiological Systems</topic><topic>ACETYLCHOLINE</topic><topic>Acetylcholine - pharmacology</topic><topic>ACETYLSALICYLIC ACID</topic><topic>ALKALINE EARTH METALS</topic><topic>AMINES</topic><topic>AMMONIUM COMPOUNDS</topic><topic>ANALGESICS</topic><topic>ANIMALS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BODY</topic><topic>CALCIUM</topic><topic>Calcium - pharmacology</topic><topic>CARBOXYLIC ACIDS</topic><topic>Dose-Response Relationship, Drug</topic><topic>DRUGS</topic><topic>ELEMENTS</topic><topic>ESTERS</topic><topic>ESTROGENS</topic><topic>Female</topic><topic>FEMALE GENITALS</topic><topic>HORMONES</topic><topic>HYDROXY ACIDS</topic><topic>IN VITRO</topic><topic>In Vitro Techniques</topic><topic>Indomethacin - pharmacology</topic><topic>MAMMALS</topic><topic>METALS</topic><topic>ORGANIC ACIDS</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANS</topic><topic>PARASYMPATHOMIMETICS</topic><topic>PHYSIOLOGY</topic><topic>Pregnancy</topic><topic>PROSTAGLANDINS</topic><topic>Prostaglandins - biosynthesis</topic><topic>QUATERNARY COMPOUNDS</topic><topic>RATS</topic><topic>RODENTS</topic><topic>STEROID HORMONES</topic><topic>Uterine Contraction - drug effects</topic><topic>UTERUS</topic><topic>Uterus - metabolism</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hargrove, J.L.</creatorcontrib><creatorcontrib>Nesbitt, D.</creatorcontrib><creatorcontrib>Gaspar, M.J.</creatorcontrib><creatorcontrib>Ellis, L.C.</creatorcontrib><creatorcontrib>Utah State Univ., Logan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Am. J. Obstet. Gynecol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hargrove, J.L.</au><au>Nesbitt, D.</au><au>Gaspar, M.J.</au><au>Ellis, L.C.</au><aucorp>Utah State Univ., Logan</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indomethacin induces rat uterine contractions in vitro and alters reactivity to calcium and acetylcholine</atitle><jtitle>Am. J. Obstet. Gynecol.; (United States)</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1976-01-01</date><risdate>1976</risdate><volume>124</volume><issue>1</issue><spage>25</spage><epage>29</epage><pages>25-29</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>The initial contractions of uteri in vitro from castrated, estrogen-treated rats, were markedly diminished following replacement with fresh bathing medium. Indomethacin and aspirin (10−5 to 10−4M) strongly stimulated such quiescent preparations and reduced their subsequent responsiveness to Ca++. Reintroducing the initial bathing medium (which contained prostaglandin-like material), or adding prostaglandin F2α to the fresh medium, initiated uterine contractions and restored responsiveness to calcium ion. Injections of indomethacin into castrated, estrogen-treated rats reduced initial in vitro uterine motility, abolished production of prostaglandin-like compounds, and prevented either indomethacin, aspirin, or Ca++ from stimulating uterine contractions. Uterine responsiveness to acetylcholine in vitro was significantly reduced in rats pretreated with indomethacin.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1244744</pmid><doi>10.1016/0002-9378(76)90006-5</doi><tpages>5</tpages></addata></record> |
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| ispartof | Am. J. Obstet. Gynecol.; (United States), 1976-01, Vol.124 (1), p.25-29 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| subjects | 551000 - Physiological Systems ACETYLCHOLINE Acetylcholine - pharmacology ACETYLSALICYLIC ACID ALKALINE EARTH METALS AMINES AMMONIUM COMPOUNDS ANALGESICS ANIMALS BASIC BIOLOGICAL SCIENCES BIOLOGICAL EFFECTS BODY CALCIUM Calcium - pharmacology CARBOXYLIC ACIDS Dose-Response Relationship, Drug DRUGS ELEMENTS ESTERS ESTROGENS Female FEMALE GENITALS HORMONES HYDROXY ACIDS IN VITRO In Vitro Techniques Indomethacin - pharmacology MAMMALS METALS ORGANIC ACIDS ORGANIC COMPOUNDS ORGANS PARASYMPATHOMIMETICS PHYSIOLOGY Pregnancy PROSTAGLANDINS Prostaglandins - biosynthesis QUATERNARY COMPOUNDS RATS RODENTS STEROID HORMONES Uterine Contraction - drug effects UTERUS Uterus - metabolism VERTEBRATES |
| title | Indomethacin induces rat uterine contractions in vitro and alters reactivity to calcium and acetylcholine |
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