Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity

The interaction of insulin with human circulating granulocytes was studied with the use of 125I-insulin. Human granulocytes, isolated from blood by the Böyum technique, showed high insulin-degrading activity in vitro which almost obscured the presence of specific, high affinity binding sites. Degra...

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Veröffentlicht in:	The Journal of biological chemistry 1976-05, Vol.251 (9), p.2761-2769
Hauptverfasser:	Fussganger, R D, Kahn, C R, Roth, J, De Meyts, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Binding, Competitive Buffers Granulocytes - metabolism Humans Hydrogen-Ion Concentration Insulin - metabolism Kinetics Leukocytes - metabolism Lymphocytes - metabolism Protein Binding Receptors, Cell Surface
Online-Zugang:	Volltext
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