Desmosterol Deposition in Human and Experimental Atherosclerosis
The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposit...
Gespeichert in:
| Veröffentlicht in: | Circulation research 1963-02, Vol.12 (2), p.228-234 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 234 |
|---|---|
| container_issue | 2 |
| container_start_page | 228 |
| container_title | Circulation research |
| container_volume | 12 |
| creator | Herndon, James H Siperstein, Marvin D |
| description | The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition. Furthermore, in the induced atherosclerotic plaques of rabbits desmosterol has been found to deposit at least as readily as does cholesterol. It is concluded from these observations that the replacement of serum cholesterol with desmosterol does not seem to offer a rational approach to the treatment of atherosclerosis. |
| doi_str_mv | 10.1161/01.res.12.2.228 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83235486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83235486</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4833-61ba3e465fb36d5dd4b77b880068213434396ec9d81e30d46f743e49c63e9d013</originalsourceid><addsrcrecordid>eNpFkMtLxDAQxoMouj7O3qQnb11nMmma3BRdHyAIPs6hj1m2mrZr06L-90Z2QT5mhoHffAyfEKcIc0SNF4DzgcMc5TxKmh0xw0yqVGU57ooZANg0J4IDcRjCOwAqknZfHCDZjKzFmbi84dD2YeSh98kNr_vQjE3fJU2X3E9t0SVFVyeL7zUPTcvdWPjkalxFOFT-rzfhWOwtCx_4ZDuPxNvt4vX6Pn18unu4vnpMK2WIUo1lQax0tixJ11ldqzLPS2MAtJFIKspqrmxtkAlqpZe5irytNLGtAelInG9810P_OXEYXduEir0vOu6n4AxJypTREbzYgFX8Lwy8dOv4ezH8OAT3F5oDdM-LF4fSRUkTL8621lPZcv3Pb1OKgNoAX72PSYUPP33x4FZc-HHlYspAgDJFqwlk3NJYSPQLnKd2tQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83235486</pqid></control><display><type>article</type><title>Desmosterol Deposition in Human and Experimental Atherosclerosis</title><source>MEDLINE</source><source>American Heart Association Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Journals@Ovid Ovid Autoload</source><creator>Herndon, James H ; Siperstein, Marvin D</creator><creatorcontrib>Herndon, James H ; Siperstein, Marvin D</creatorcontrib><description>The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition. Furthermore, in the induced atherosclerotic plaques of rabbits desmosterol has been found to deposit at least as readily as does cholesterol. It is concluded from these observations that the replacement of serum cholesterol with desmosterol does not seem to offer a rational approach to the treatment of atherosclerosis.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.res.12.2.228</identifier><identifier>PMID: 13953991</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Alcohols ; Arteriosclerosis ; Atherosclerosis ; Desmosterol ; Humans ; Old Medline ; Sterols</subject><ispartof>Circulation research, 1963-02, Vol.12 (2), p.228-234</ispartof><rights>1963 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4833-61ba3e465fb36d5dd4b77b880068213434396ec9d81e30d46f743e49c63e9d013</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,3676,27913,27914</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13953991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herndon, James H</creatorcontrib><creatorcontrib>Siperstein, Marvin D</creatorcontrib><title>Desmosterol Deposition in Human and Experimental Atherosclerosis</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition. Furthermore, in the induced atherosclerotic plaques of rabbits desmosterol has been found to deposit at least as readily as does cholesterol. It is concluded from these observations that the replacement of serum cholesterol with desmosterol does not seem to offer a rational approach to the treatment of atherosclerosis.</description><subject>Alcohols</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Desmosterol</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Sterols</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtLxDAQxoMouj7O3qQnb11nMmma3BRdHyAIPs6hj1m2mrZr06L-90Z2QT5mhoHffAyfEKcIc0SNF4DzgcMc5TxKmh0xw0yqVGU57ooZANg0J4IDcRjCOwAqknZfHCDZjKzFmbi84dD2YeSh98kNr_vQjE3fJU2X3E9t0SVFVyeL7zUPTcvdWPjkalxFOFT-rzfhWOwtCx_4ZDuPxNvt4vX6Pn18unu4vnpMK2WIUo1lQax0tixJ11ldqzLPS2MAtJFIKspqrmxtkAlqpZe5irytNLGtAelInG9810P_OXEYXduEir0vOu6n4AxJypTREbzYgFX8Lwy8dOv4ezH8OAT3F5oDdM-LF4fSRUkTL8621lPZcv3Pb1OKgNoAX72PSYUPP33x4FZc-HHlYspAgDJFqwlk3NJYSPQLnKd2tQ</recordid><startdate>196302</startdate><enddate>196302</enddate><creator>Herndon, James H</creator><creator>Siperstein, Marvin D</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196302</creationdate><title>Desmosterol Deposition in Human and Experimental Atherosclerosis</title><author>Herndon, James H ; Siperstein, Marvin D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4833-61ba3e465fb36d5dd4b77b880068213434396ec9d81e30d46f743e49c63e9d013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Alcohols</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>Desmosterol</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Sterols</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herndon, James H</creatorcontrib><creatorcontrib>Siperstein, Marvin D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herndon, James H</au><au>Siperstein, Marvin D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Desmosterol Deposition in Human and Experimental Atherosclerosis</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1963-02</date><risdate>1963</risdate><volume>12</volume><issue>2</issue><spage>228</spage><epage>234</epage><pages>228-234</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition. Furthermore, in the induced atherosclerotic plaques of rabbits desmosterol has been found to deposit at least as readily as does cholesterol. It is concluded from these observations that the replacement of serum cholesterol with desmosterol does not seem to offer a rational approach to the treatment of atherosclerosis.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>13953991</pmid><doi>10.1161/01.res.12.2.228</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-7330 |
| ispartof | Circulation research, 1963-02, Vol.12 (2), p.228-234 |
| issn | 0009-7330 1524-4571 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83235486 |
| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Alcohols Arteriosclerosis Atherosclerosis Desmosterol Humans Old Medline Sterols |
| title | Desmosterol Deposition in Human and Experimental Atherosclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T09%3A42%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Desmosterol%20Deposition%20in%20Human%20and%20Experimental%20Atherosclerosis&rft.jtitle=Circulation%20research&rft.au=Herndon,%20James%20H&rft.date=1963-02&rft.volume=12&rft.issue=2&rft.spage=228&rft.epage=234&rft.pages=228-234&rft.issn=0009-7330&rft.eissn=1524-4571&rft_id=info:doi/10.1161/01.res.12.2.228&rft_dat=%3Cproquest_cross%3E83235486%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83235486&rft_id=info:pmid/13953991&rfr_iscdi=true |