Field Studies of Protection from Infection by Experimental Trachoma Virus Vaccine in Preschool-Aged Children on Taiwan.
Summary Field trials of experimental egg-grown trachoma virus vaccine have been carried out in preschool-aged children in 2 rural areas on Taiwan. Four hundred and five children randomly divided between a placebo and trachoma vaccine groups have been followed for 2 1/2 years during which 4 injection...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1963-03, Vol.112 (3), p.589-595 |
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| container_issue | 3 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 112 |
| creator | Grayston, J. Thomas Woolridge, Robert L. Wang, San-Pin Yen, Chun-Hui Yang, Chung-Yen Cheng, King-Hsing Chang, I-Hsiung |
| description | Summary
Field trials of experimental egg-grown trachoma virus vaccine have been carried out in preschool-aged children in 2 rural areas on Taiwan. Four hundred and five children randomly divided between a placebo and trachoma vaccine groups have been followed for 2 1/2 years during which 4 injections of vaccine have been given. Eighteen per cent of the placebo group have converted to trachoma compared to 8% of those receiving vaccine. An average of 2.98 months of trachoma have been observed in the placebo group compared to 1.22 months in the vaccine group. Both these measures suggested that the vaccine was approximately 60% effective in reducing trachoma. A third study in an urban area with 89 children showed similar vaccine effectiveness. |
| doi_str_mv | 10.3181/00379727-112-28112 |
| format | Article |
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Field trials of experimental egg-grown trachoma virus vaccine have been carried out in preschool-aged children in 2 rural areas on Taiwan. Four hundred and five children randomly divided between a placebo and trachoma vaccine groups have been followed for 2 1/2 years during which 4 injections of vaccine have been given. Eighteen per cent of the placebo group have converted to trachoma compared to 8% of those receiving vaccine. An average of 2.98 months of trachoma have been observed in the placebo group compared to 1.22 months in the vaccine group. Both these measures suggested that the vaccine was approximately 60% effective in reducing trachoma. A third study in an urban area with 89 children showed similar vaccine effectiveness.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-112-28112</identifier><identifier>PMID: 13950005</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Bacterial Vaccines ; Child ; Humans ; Old Medline ; Taiwan ; Trachoma ; Vaccines</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1963-03, Vol.112 (3), p.589-595</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-321d83da80a7e2974ad8fcff03154d2cadf2646a595de62aea60ab47e4a7c7bf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13950005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grayston, J. Thomas</creatorcontrib><creatorcontrib>Woolridge, Robert L.</creatorcontrib><creatorcontrib>Wang, San-Pin</creatorcontrib><creatorcontrib>Yen, Chun-Hui</creatorcontrib><creatorcontrib>Yang, Chung-Yen</creatorcontrib><creatorcontrib>Cheng, King-Hsing</creatorcontrib><creatorcontrib>Chang, I-Hsiung</creatorcontrib><title>Field Studies of Protection from Infection by Experimental Trachoma Virus Vaccine in Preschool-Aged Children on Taiwan.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Field trials of experimental egg-grown trachoma virus vaccine have been carried out in preschool-aged children in 2 rural areas on Taiwan. Four hundred and five children randomly divided between a placebo and trachoma vaccine groups have been followed for 2 1/2 years during which 4 injections of vaccine have been given. Eighteen per cent of the placebo group have converted to trachoma compared to 8% of those receiving vaccine. An average of 2.98 months of trachoma have been observed in the placebo group compared to 1.22 months in the vaccine group. Both these measures suggested that the vaccine was approximately 60% effective in reducing trachoma. A third study in an urban area with 89 children showed similar vaccine effectiveness.</description><subject>Bacterial Vaccines</subject><subject>Child</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Taiwan</subject><subject>Trachoma</subject><subject>Vaccines</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQQK2Kqmy3_QM9VD5xC_gjiZMjWkGLhESlbvdqzdpjMErsxU4E_Pt6u1tx42LL8psnzSPkG2fnknf8gjGpeiVUxbmoRFfOD2TBG9lUsu37E7LYA9WeOCWfc35kjDdKtJ_IKZd9wxhrFuT52uNg6e9pth4zjY7-SnFCM_kYqEtxpDfBHZ_bV3r1ssPkRwwTDHSdwDzEEejGpznTDRjjA1IfigNz-YpDdXmPlq4e_GATBloka_DPEM6_kI8Ohoxfj_eS_Lm-Wq9-Vrd3P25Wl7eVkbKfKim47aSFjoFC0asabOeMc0zyprbCgHWirVto-sZiKwChZbCtFdagjNo6uSRnB-8uxacZ86RHnw0OAwSMc9adFJJz1RdQHECTYs4Jnd6VRSG9as70Prf-n1uX0Ppf7jL0_WiftyPat5Fj3wJcHIAM96gf45xC2fY95V_-rYnO</recordid><startdate>196303</startdate><enddate>196303</enddate><creator>Grayston, J. Thomas</creator><creator>Woolridge, Robert L.</creator><creator>Wang, San-Pin</creator><creator>Yen, Chun-Hui</creator><creator>Yang, Chung-Yen</creator><creator>Cheng, King-Hsing</creator><creator>Chang, I-Hsiung</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196303</creationdate><title>Field Studies of Protection from Infection by Experimental Trachoma Virus Vaccine in Preschool-Aged Children on Taiwan.</title><author>Grayston, J. Thomas ; Woolridge, Robert L. ; Wang, San-Pin ; Yen, Chun-Hui ; Yang, Chung-Yen ; Cheng, King-Hsing ; Chang, I-Hsiung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-321d83da80a7e2974ad8fcff03154d2cadf2646a595de62aea60ab47e4a7c7bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Bacterial Vaccines</topic><topic>Child</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Taiwan</topic><topic>Trachoma</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grayston, J. Thomas</creatorcontrib><creatorcontrib>Woolridge, Robert L.</creatorcontrib><creatorcontrib>Wang, San-Pin</creatorcontrib><creatorcontrib>Yen, Chun-Hui</creatorcontrib><creatorcontrib>Yang, Chung-Yen</creatorcontrib><creatorcontrib>Cheng, King-Hsing</creatorcontrib><creatorcontrib>Chang, I-Hsiung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grayston, J. Thomas</au><au>Woolridge, Robert L.</au><au>Wang, San-Pin</au><au>Yen, Chun-Hui</au><au>Yang, Chung-Yen</au><au>Cheng, King-Hsing</au><au>Chang, I-Hsiung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Field Studies of Protection from Infection by Experimental Trachoma Virus Vaccine in Preschool-Aged Children on Taiwan.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1963-03</date><risdate>1963</risdate><volume>112</volume><issue>3</issue><spage>589</spage><epage>595</epage><pages>589-595</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Field trials of experimental egg-grown trachoma virus vaccine have been carried out in preschool-aged children in 2 rural areas on Taiwan. Four hundred and five children randomly divided between a placebo and trachoma vaccine groups have been followed for 2 1/2 years during which 4 injections of vaccine have been given. Eighteen per cent of the placebo group have converted to trachoma compared to 8% of those receiving vaccine. An average of 2.98 months of trachoma have been observed in the placebo group compared to 1.22 months in the vaccine group. Both these measures suggested that the vaccine was approximately 60% effective in reducing trachoma. A third study in an urban area with 89 children showed similar vaccine effectiveness.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13950005</pmid><doi>10.3181/00379727-112-28112</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1963-03, Vol.112 (3), p.589-595 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83231179 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Bacterial Vaccines Child Humans Old Medline Taiwan Trachoma Vaccines |
| title | Field Studies of Protection from Infection by Experimental Trachoma Virus Vaccine in Preschool-Aged Children on Taiwan. |
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