STREPTOCOCCAL PREPARATION AS AN ACTIVATOR OF HOST-MEDIATED IMMUNE RESPONSE: CELLULAR IMMUNITY AND ALTERNATE PATHWAY OF COMPLEMENT
Streptococcal preparation, OK-432, was examined for its ability to initiate a host-mediated immune response. Aged individuals with negative skin response to phytohemagglutinin (PHA), as well as reduced in vitro blastoid transformation of lymphocytes, were treated with OK-432, and the response to PHA...
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| Veröffentlicht in: | GANN Japanese Journal of Cancer Research 1975/12/31, Vol.66(6), pp.675-678 |
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| container_end_page | 678 |
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| container_issue | 6 |
| container_start_page | 675 |
| container_title | GANN Japanese Journal of Cancer Research |
| container_volume | 66 |
| creator | KONDO, Motoharu IKEZAKI, Minoru IMANISHI, Hitoshi NISHGAKI, Itsuro HOSOKAWA, Keimei MASUDA, Masasuke |
| description | Streptococcal preparation, OK-432, was examined for its ability to initiate a host-mediated immune response. Aged individuals with negative skin response to phytohemagglutinin (PHA), as well as reduced in vitro blastoid transformation of lymphocytes, were treated with OK-432, and the response to PHA appeared in two out of three cases. The preparation was also demonstrated to convert C3 proactivator of complement when incubated with fresh human serum, as tested by immunoelectrophoresis, indicating the possibility that OK-432 might activate the alternate pathway of complement. |
| doi_str_mv | 10.20772/cancersci1959.66.6_675 |
| format | Article |
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Aged individuals with negative skin response to phytohemagglutinin (PHA), as well as reduced in vitro blastoid transformation of lymphocytes, were treated with OK-432, and the response to PHA appeared in two out of three cases. The preparation was also demonstrated to convert C3 proactivator of complement when incubated with fresh human serum, as tested by immunoelectrophoresis, indicating the possibility that OK-432 might activate the alternate pathway of complement.</description><identifier>ISSN: 0016-450X</identifier><identifier>DOI: 10.20772/cancersci1959.66.6_675</identifier><identifier>PMID: 1225721</identifier><language>eng</language><publisher>Japan: The Japanese Cancer Association</publisher><subject>Activation of immune response ; Aged ; Antibiotics, Antineoplastic - pharmacology ; Antibiotics, Antineoplastic - therapeutic use ; Cellular immunity ; Complement C3 - metabolism ; Complement System Proteins - metabolism ; Female ; Humans ; Immunity, Cellular - drug effects ; Immunologic Deficiency Syndromes - drug therapy ; Lymphocyte Activation - drug effects ; Male ; Picibanil ; Streptococcus</subject><ispartof>GANN Japanese Journal of Cancer Research, 1975/12/31, Vol.66(6), pp.675-678</ispartof><rights>The Japanese Cancer Association</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1225721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KONDO, Motoharu</creatorcontrib><creatorcontrib>IKEZAKI, Minoru</creatorcontrib><creatorcontrib>IMANISHI, Hitoshi</creatorcontrib><creatorcontrib>NISHGAKI, Itsuro</creatorcontrib><creatorcontrib>HOSOKAWA, Keimei</creatorcontrib><creatorcontrib>MASUDA, Masasuke</creatorcontrib><title>STREPTOCOCCAL PREPARATION AS AN ACTIVATOR OF HOST-MEDIATED IMMUNE RESPONSE: CELLULAR IMMUNITY AND ALTERNATE PATHWAY OF COMPLEMENT</title><title>GANN Japanese Journal of Cancer Research</title><addtitle>GANN Japanese Journal of Cancer Research</addtitle><description>Streptococcal preparation, OK-432, was examined for its ability to initiate a host-mediated immune response. Aged individuals with negative skin response to phytohemagglutinin (PHA), as well as reduced in vitro blastoid transformation of lymphocytes, were treated with OK-432, and the response to PHA appeared in two out of three cases. The preparation was also demonstrated to convert C3 proactivator of complement when incubated with fresh human serum, as tested by immunoelectrophoresis, indicating the possibility that OK-432 might activate the alternate pathway of complement.</description><subject>Activation of immune response</subject><subject>Aged</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Antibiotics, Antineoplastic - therapeutic use</subject><subject>Cellular immunity</subject><subject>Complement C3 - metabolism</subject><subject>Complement System Proteins - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity, Cellular - drug effects</subject><subject>Immunologic Deficiency Syndromes - drug therapy</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Male</subject><subject>Picibanil</subject><subject>Streptococcus</subject><issn>0016-450X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtPwzAQhH0AlQr6ExA5cUvxo7aTY5SmNKitq8RF3CwncSBV-iBuD_x7jBqB2MO3Ws1opB0AHhAcY8g5fir1vjSdLRsU0nDM2JgpxukVGEKImD-h8O0GjKzdQjcMc8zZAAwQxpRjNAQvucyStRSxiONo4a3dEWWRTMXKi3Ivcoxl-hpJkXli5s1FLv1lMk0jmUy9dLncrBIvS_K1WOXJHbiudWvNqN-3YDNLZDz3F-I5deH-luDw5FdhVRMEcVFzXkJmTI1IDX8YlEXhgKqJmWjEcc0rjCAJDSUQU4R1WVNakVvweMk9dofPs7EntWtsadpW783hbFVAMAoICZzxvjeei52p1LFrdrr7Uv3zTk8v-tae9Lv51XV3asrWqH_NKuZ67cHpn-dDd8rsyTdvJXEg</recordid><startdate>19750101</startdate><enddate>19750101</enddate><creator>KONDO, Motoharu</creator><creator>IKEZAKI, Minoru</creator><creator>IMANISHI, Hitoshi</creator><creator>NISHGAKI, Itsuro</creator><creator>HOSOKAWA, Keimei</creator><creator>MASUDA, Masasuke</creator><general>The Japanese Cancer Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19750101</creationdate><title>STREPTOCOCCAL PREPARATION AS AN ACTIVATOR OF HOST-MEDIATED IMMUNE RESPONSE</title><author>KONDO, Motoharu ; IKEZAKI, Minoru ; IMANISHI, Hitoshi ; NISHGAKI, Itsuro ; HOSOKAWA, Keimei ; MASUDA, Masasuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j329t-d9df3102bf77c06eef13f0ef138cbb38c1d4e4a172f7d21039e5302512acf55d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Activation of immune response</topic><topic>Aged</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Antibiotics, Antineoplastic - therapeutic use</topic><topic>Cellular immunity</topic><topic>Complement C3 - metabolism</topic><topic>Complement System Proteins - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity, Cellular - drug effects</topic><topic>Immunologic Deficiency Syndromes - drug therapy</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Male</topic><topic>Picibanil</topic><topic>Streptococcus</topic><toplevel>online_resources</toplevel><creatorcontrib>KONDO, Motoharu</creatorcontrib><creatorcontrib>IKEZAKI, Minoru</creatorcontrib><creatorcontrib>IMANISHI, Hitoshi</creatorcontrib><creatorcontrib>NISHGAKI, Itsuro</creatorcontrib><creatorcontrib>HOSOKAWA, Keimei</creatorcontrib><creatorcontrib>MASUDA, Masasuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>GANN Japanese Journal of Cancer Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KONDO, Motoharu</au><au>IKEZAKI, Minoru</au><au>IMANISHI, Hitoshi</au><au>NISHGAKI, Itsuro</au><au>HOSOKAWA, Keimei</au><au>MASUDA, Masasuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>STREPTOCOCCAL PREPARATION AS AN ACTIVATOR OF HOST-MEDIATED IMMUNE RESPONSE: CELLULAR IMMUNITY AND ALTERNATE PATHWAY OF COMPLEMENT</atitle><jtitle>GANN Japanese Journal of Cancer Research</jtitle><addtitle>GANN Japanese Journal of Cancer Research</addtitle><date>1975-01-01</date><risdate>1975</risdate><volume>66</volume><issue>6</issue><spage>675</spage><epage>678</epage><pages>675-678</pages><issn>0016-450X</issn><abstract>Streptococcal preparation, OK-432, was examined for its ability to initiate a host-mediated immune response. Aged individuals with negative skin response to phytohemagglutinin (PHA), as well as reduced in vitro blastoid transformation of lymphocytes, were treated with OK-432, and the response to PHA appeared in two out of three cases. The preparation was also demonstrated to convert C3 proactivator of complement when incubated with fresh human serum, as tested by immunoelectrophoresis, indicating the possibility that OK-432 might activate the alternate pathway of complement.</abstract><cop>Japan</cop><pub>The Japanese Cancer Association</pub><pmid>1225721</pmid><doi>10.20772/cancersci1959.66.6_675</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0016-450X |
| ispartof | GANN Japanese Journal of Cancer Research, 1975/12/31, Vol.66(6), pp.675-678 |
| issn | 0016-450X |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Activation of immune response Aged Antibiotics, Antineoplastic - pharmacology Antibiotics, Antineoplastic - therapeutic use Cellular immunity Complement C3 - metabolism Complement System Proteins - metabolism Female Humans Immunity, Cellular - drug effects Immunologic Deficiency Syndromes - drug therapy Lymphocyte Activation - drug effects Male Picibanil Streptococcus |
| title | STREPTOCOCCAL PREPARATION AS AN ACTIVATOR OF HOST-MEDIATED IMMUNE RESPONSE: CELLULAR IMMUNITY AND ALTERNATE PATHWAY OF COMPLEMENT |
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