Studies on the Method of Thermal Analysis of Organic Medicinals. III. Relations between Methods of Sample Preparation and Obtained Phase Diagrams
Three methods of sample preparation for the thermal analysis by the thaw-melt method were proposed. The heating procedure for solidification of the melt was proved to be very effective, especially for those samples that are apt to take vitreous states after fusion. Tests concerning both reliability...
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| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1963/09/25, Vol.11(9), pp.1108-1122 |
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| container_title | Chemical & pharmaceutical bulletin |
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| creator | Sekiguchi, Keiji Ueda, Yoshio Nakamori, Yoshiko |
| description | Three methods of sample preparation for the thermal analysis by the thaw-melt method were proposed. The heating procedure for solidification of the melt was proved to be very effective, especially for those samples that are apt to take vitreous states after fusion. Tests concerning both reliability and applicability the modified thaw-melt method were carried out on twelve kinds of organic binary system to which the application of the original method of Rheinboldt is thought to be difficult. The results indicate that the modified method is more accurate and reliable than the original one. The meaning and the use of the thaw point due to the metastable eutectic point in the system of compound formation were discussed. |
| doi_str_mv | 10.1248/cpb.11.1108 |
| format | Article |
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III. Relations between Methods of Sample Preparation and Obtained Phase Diagrams</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Sekiguchi, Keiji ; Ueda, Yoshio ; Nakamori, Yoshiko</creator><creatorcontrib>Sekiguchi, Keiji ; Ueda, Yoshio ; Nakamori, Yoshiko</creatorcontrib><description>Three methods of sample preparation for the thermal analysis by the thaw-melt method were proposed. The heating procedure for solidification of the melt was proved to be very effective, especially for those samples that are apt to take vitreous states after fusion. Tests concerning both reliability and applicability the modified thaw-melt method were carried out on twelve kinds of organic binary system to which the application of the original method of Rheinboldt is thought to be difficult. The results indicate that the modified method is more accurate and reliable than the original one. The meaning and the use of the thaw point due to the metastable eutectic point in the system of compound formation were discussed.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.11.1108</identifier><identifier>PMID: 14068729</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>4-Aminobenzoic Acid ; Aminopyrine ; Ammonium Compounds ; Aniline Compounds ; Barbiturates ; Benzoates ; Biphenyl Compounds ; Caffeine ; Chemistry Techniques, Analytical ; Niacinamide ; Old Medline ; ortho-Aminobenzoates ; Quaternary Ammonium Compounds ; Theophylline</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1963/09/25, Vol.11(9), pp.1108-1122</ispartof><rights>The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3998-7016991c4e1304302a0c3e9a48a5f8949d5c14fe3b0f04afdc804844d4de6acc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14068729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sekiguchi, Keiji</creatorcontrib><creatorcontrib>Ueda, Yoshio</creatorcontrib><creatorcontrib>Nakamori, Yoshiko</creatorcontrib><title>Studies on the Method of Thermal Analysis of Organic Medicinals. 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The meaning and the use of the thaw point due to the metastable eutectic point in the system of compound formation were discussed.</description><subject>4-Aminobenzoic Acid</subject><subject>Aminopyrine</subject><subject>Ammonium Compounds</subject><subject>Aniline Compounds</subject><subject>Barbiturates</subject><subject>Benzoates</subject><subject>Biphenyl Compounds</subject><subject>Caffeine</subject><subject>Chemistry Techniques, Analytical</subject><subject>Niacinamide</subject><subject>Old Medline</subject><subject>ortho-Aminobenzoates</subject><subject>Quaternary Ammonium Compounds</subject><subject>Theophylline</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv1DAURi0EokNhxR55xQZluH5kYi-rlsdIRVPRso5u7JuJq7ywM6r6M_jHJJ2BSle-kr_js_DH2HsBayG1-ezGai3EPGBesJVQushyKdVLtgIAm0m1UWfsTUr3ADKHQr1mZ0LDxhTSrtif2-ngAyU-9HxqiP-gqRk8H2p-11DssOUXPbaPKaTlbhf32Ac3Uz64MAdpzbfb7Zr_pBanMPSJVzQ9EPUn0dOrW-zGlvhNpBHjE8ax93xXTRh68vymwUT8KuA-Ypfeslf1LKZ3p33Ofn39cnf5PbvefdteXlxnTllrsgLExlrhNAkFWoFEcIosaoN5bay2PndC16QqqEFj7Z0BbbT22tMGnVPn7OPRO8bh94HSVHYhOWpb7Gk4pNIoCUVh5Ax-OoIuDilFqssxhg7jYymgXBoo5wZKIcqlgZn-cNIeqo78M3v68hm4OgL3acI9_QcwTsG1tMiEzc0itP8OMM9xg7GkXv0F0JyaBg</recordid><startdate>1963</startdate><enddate>1963</enddate><creator>Sekiguchi, Keiji</creator><creator>Ueda, Yoshio</creator><creator>Nakamori, Yoshiko</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1963</creationdate><title>Studies on the Method of Thermal Analysis of Organic Medicinals. 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| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1963/09/25, Vol.11(9), pp.1108-1122 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83207782 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | 4-Aminobenzoic Acid Aminopyrine Ammonium Compounds Aniline Compounds Barbiturates Benzoates Biphenyl Compounds Caffeine Chemistry Techniques, Analytical Niacinamide Old Medline ortho-Aminobenzoates Quaternary Ammonium Compounds Theophylline |
| title | Studies on the Method of Thermal Analysis of Organic Medicinals. III. Relations between Methods of Sample Preparation and Obtained Phase Diagrams |
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