Effect of Thymectomy on the Golden Hamster (Mesocricetus Auratus). I. Wasting Disease
A fatal progressive wasting disease was produced in male hamsters by thymectomy. The disease was characterized by generalized atrophy of lymphoid tissue, pancytopenia and decreased gamma globulins. Two unique features of this wasting disease were its occurrence in a significant number of animals thy...
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| Veröffentlicht in: | Blood 1963-09, Vol.22 (3), p.252-271 |
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| creator | D. Sherman, JOSEPH Adner, Marvin M. William, Dameshek |
| description | A fatal progressive wasting disease was produced in male hamsters by thymectomy. The disease was characterized by generalized atrophy of lymphoid tissue, pancytopenia and decreased gamma globulins. Two unique features of this wasting disease were its occurrence in a significant number of animals thymectomized at 4 weeks of age and its development in males only. The thymectomized female hamster could be made to waste if treated with testosterone proprionate or bilateral oophorectomy. The mechanisms involved in the post-thymectomy wasting disease are discussed, as well as the relationship of runt disease (graft vs. host disease) to thymic wasting. The relationship of the thymus to lymphoid tissue, immune globulins, and certain diseases in man are pointed out. The possibility that the wasted thymectomized hamster may be an experimental model for the human disease known as "alymphocytosis" or "lymphocytophthisis" is discussed. |
| doi_str_mv | 10.1182/blood.V22.3.252.252 |
| format | Article |
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I. Wasting Disease</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>D. Sherman, JOSEPH ; Adner, Marvin M. ; William, Dameshek</creator><creatorcontrib>D. Sherman, JOSEPH ; Adner, Marvin M. ; William, Dameshek</creatorcontrib><description>A fatal progressive wasting disease was produced in male hamsters by thymectomy. The disease was characterized by generalized atrophy of lymphoid tissue, pancytopenia and decreased gamma globulins. Two unique features of this wasting disease were its occurrence in a significant number of animals thymectomized at 4 weeks of age and its development in males only. The thymectomized female hamster could be made to waste if treated with testosterone proprionate or bilateral oophorectomy. The mechanisms involved in the post-thymectomy wasting disease are discussed, as well as the relationship of runt disease (graft vs. host disease) to thymic wasting. The relationship of the thymus to lymphoid tissue, immune globulins, and certain diseases in man are pointed out. The possibility that the wasted thymectomized hamster may be an experimental model for the human disease known as "alymphocytosis" or "lymphocytophthisis" is discussed.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V22.3.252.252</identifier><identifier>PMID: 14056866</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Agammaglobulinemia ; Anemia ; Anemia, Aplastic ; Animals ; Atrophy ; Colon ; Cricetinae ; Female ; Humans ; Lymphoid Tissue ; Mesocricetus ; Old Medline ; Ovary ; Physiology ; Spleen ; Thymectomy ; Thymus Gland</subject><ispartof>Blood, 1963-09, Vol.22 (3), p.252-271</ispartof><rights>1963 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2472-a135649438799732d4d15c9c04ba1fb286354559c0a67dd78ff33e8ceb791cd63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14056866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D. Sherman, JOSEPH</creatorcontrib><creatorcontrib>Adner, Marvin M.</creatorcontrib><creatorcontrib>William, Dameshek</creatorcontrib><title>Effect of Thymectomy on the Golden Hamster (Mesocricetus Auratus). I. Wasting Disease</title><title>Blood</title><addtitle>Blood</addtitle><description>A fatal progressive wasting disease was produced in male hamsters by thymectomy. The disease was characterized by generalized atrophy of lymphoid tissue, pancytopenia and decreased gamma globulins. Two unique features of this wasting disease were its occurrence in a significant number of animals thymectomized at 4 weeks of age and its development in males only. The thymectomized female hamster could be made to waste if treated with testosterone proprionate or bilateral oophorectomy. The mechanisms involved in the post-thymectomy wasting disease are discussed, as well as the relationship of runt disease (graft vs. host disease) to thymic wasting. The relationship of the thymus to lymphoid tissue, immune globulins, and certain diseases in man are pointed out. The possibility that the wasted thymectomized hamster may be an experimental model for the human disease known as "alymphocytosis" or "lymphocytophthisis" is discussed.</description><subject>Agammaglobulinemia</subject><subject>Anemia</subject><subject>Anemia, Aplastic</subject><subject>Animals</subject><subject>Atrophy</subject><subject>Colon</subject><subject>Cricetinae</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphoid Tissue</subject><subject>Mesocricetus</subject><subject>Old Medline</subject><subject>Ovary</subject><subject>Physiology</subject><subject>Spleen</subject><subject>Thymectomy</subject><subject>Thymus Gland</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElLBDEQhYMoOi6_QJCcRA_dZu3l4GFwB8WLyzGkk2qNdHc06Rbm35txBrx5eFRRvHpFfQgdUpJTWrGzpvPe5i-M5Txnki21gWZUsiojhJFNNCOEFJmoS7qDdmP8IIQKzuQ22qGCyKIqihl6vmpbMCP2LX56X_Sp9f0C-wGP74BvfGdhwLe6jyMEfPIA0ZvgDIxTxPMp6FRPc3yX41cdRze84UsXQUfYR1ut7iIcrOseer6-erq4ze4fb-4u5veZYaJkmaZcFqIWvCrruuTMCkulqQ0RjaZtw6qCSyFlGuiitLas2pZzqAw0ZU2NLfgeOl7lfgb_NUEcVe-iga7TA_gpqorTWjJSJyNfGU3wMQZo1WdwvQ4LRYla0lS_NFWiqbhKJJdKW0fr-Knpwf7trPElw_nKAOnJbwdBReNgMGBdSCiV9e7fAz-tIYUL</recordid><startdate>196309</startdate><enddate>196309</enddate><creator>D. Sherman, JOSEPH</creator><creator>Adner, Marvin M.</creator><creator>William, Dameshek</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196309</creationdate><title>Effect of Thymectomy on the Golden Hamster (Mesocricetus Auratus). I. Wasting Disease</title><author>D. Sherman, JOSEPH ; Adner, Marvin M. ; William, Dameshek</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2472-a135649438799732d4d15c9c04ba1fb286354559c0a67dd78ff33e8ceb791cd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Agammaglobulinemia</topic><topic>Anemia</topic><topic>Anemia, Aplastic</topic><topic>Animals</topic><topic>Atrophy</topic><topic>Colon</topic><topic>Cricetinae</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphoid Tissue</topic><topic>Mesocricetus</topic><topic>Old Medline</topic><topic>Ovary</topic><topic>Physiology</topic><topic>Spleen</topic><topic>Thymectomy</topic><topic>Thymus Gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D. Sherman, JOSEPH</creatorcontrib><creatorcontrib>Adner, Marvin M.</creatorcontrib><creatorcontrib>William, Dameshek</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D. Sherman, JOSEPH</au><au>Adner, Marvin M.</au><au>William, Dameshek</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Thymectomy on the Golden Hamster (Mesocricetus Auratus). I. 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| ispartof | Blood, 1963-09, Vol.22 (3), p.252-271 |
| issn | 0006-4971 1528-0020 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Agammaglobulinemia Anemia Anemia, Aplastic Animals Atrophy Colon Cricetinae Female Humans Lymphoid Tissue Mesocricetus Old Medline Ovary Physiology Spleen Thymectomy Thymus Gland |
| title | Effect of Thymectomy on the Golden Hamster (Mesocricetus Auratus). I. Wasting Disease |
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