Scopolamine effects on delayed spatial alternation in the rat
Rats were trained to press two levers in alternation on discrete trials spaced 10 sec apart. During the final sessions of alternation training, error responses per opportunity on the trials that followed reinforced trials (initial trials) did not differ from error responses per opportunity on repeti...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1975-11, Vol.3 (6), p.993-1002 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Heise, George A. Hrabrich, Barbara Lilie, Nell L. Martin, Richard A. |
| description | Rats were trained to press two levers in alternation on discrete trials spaced 10 sec apart. During the final sessions of alternation training, error responses per opportunity on the trials that followed reinforced trials (initial trials) did not differ from error responses per opportunity on repetitive (correction) trials (Experiment 1). Scopolamine did not increase the rats' tendency to perseverate: drug treatment did not cause the error responses per opportunity to increase over runs of consecutive error responses (Experiment 2). Scopolamine did not impair performance when alternation was controlled by visual stimuli present in the external environment at the time of the response (Experiment 3). The disruption in delayed alternation performance produced by scopolamine was attributed to effects on stimulus discrimination, resulting in impairment of control of responding by stimuli not present in the environment at the time of the response. |
| doi_str_mv | 10.1016/0091-3057(75)90007-6 |
| format | Article |
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The disruption in delayed alternation performance produced by scopolamine was attributed to effects on stimulus discrimination, resulting in impairment of control of responding by stimuli not present in the environment at the time of the response.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/0091-3057(75)90007-6</identifier><identifier>PMID: 1223909</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Atropine - pharmacology ; Cholinergic blockers ; Conditioning, Operant - drug effects ; d-Amphetamine ; Delayed spatial alternation ; Dextroamphetamine - pharmacology ; Discrimination (Psychology) - drug effects ; Discrimination Learning - drug effects ; Male ; Perseveration ; Rats ; Scopolamine ; Scopolamine - pharmacology ; Scopolamine Derivatives ; Time Factors</subject><ispartof>Pharmacology, biochemistry and behavior, 1975-11, Vol.3 (6), p.993-1002</ispartof><rights>1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-ea334c4028b4c08a7d624efb329a4ff91f5e0cda95f1f7902fb18e33a8acdd5d3</citedby><cites>FETCH-LOGICAL-c357t-ea334c4028b4c08a7d624efb329a4ff91f5e0cda95f1f7902fb18e33a8acdd5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0091-3057(75)90007-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1223909$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heise, George A.</creatorcontrib><creatorcontrib>Hrabrich, Barbara</creatorcontrib><creatorcontrib>Lilie, Nell L.</creatorcontrib><creatorcontrib>Martin, Richard A.</creatorcontrib><title>Scopolamine effects on delayed spatial alternation in the rat</title><title>Pharmacology, biochemistry and behavior</title><addtitle>Pharmacol Biochem Behav</addtitle><description>Rats were trained to press two levers in alternation on discrete trials spaced 10 sec apart. During the final sessions of alternation training, error responses per opportunity on the trials that followed reinforced trials (initial trials) did not differ from error responses per opportunity on repetitive (correction) trials (Experiment 1). Scopolamine did not increase the rats' tendency to perseverate: drug treatment did not cause the error responses per opportunity to increase over runs of consecutive error responses (Experiment 2). Scopolamine did not impair performance when alternation was controlled by visual stimuli present in the external environment at the time of the response (Experiment 3). The disruption in delayed alternation performance produced by scopolamine was attributed to effects on stimulus discrimination, resulting in impairment of control of responding by stimuli not present in the environment at the time of the response.</description><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Cholinergic blockers</subject><subject>Conditioning, Operant - drug effects</subject><subject>d-Amphetamine</subject><subject>Delayed spatial alternation</subject><subject>Dextroamphetamine - pharmacology</subject><subject>Discrimination (Psychology) - drug effects</subject><subject>Discrimination Learning - drug effects</subject><subject>Male</subject><subject>Perseveration</subject><subject>Rats</subject><subject>Scopolamine</subject><subject>Scopolamine - pharmacology</subject><subject>Scopolamine Derivatives</subject><subject>Time Factors</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLBDEQhIMo67r6DxRyEj2MJpPJZHJQkMUXLHhQzyGTdDAyL5NZYf-9WUf05qkbqqqb-hA6puSCElpeEiJpxggXZ4KfS0KIyModNKeVYBmnQuyi-a9lHx3E-J48RV6KGZrRPGeSyDm6ejb90De69R1gcA7MGHHfYQuN3oDFcdCj1w3WzQihS3vSfIfHN8BBj4doz-kmwtHPXKDXu9uX5UO2erp_XN6sMsO4GDPQjBWmIHlVF4ZUWtgyL8DVLJe6cE5Sx4EYqyV31AlJclfTChjTlTbWcssW6HS6O4T-Yw1xVK2PBppGd9Cvo6oYlZyk4gtUTEYT-hgDODUE3-qwUZSoLTW1RaK2SJTg6puaKlPs5Of-um7B_oUmTEm_nnRIJT89BBWNh86A9SERU7b3_z_4Aq6he9o</recordid><startdate>197511</startdate><enddate>197511</enddate><creator>Heise, George A.</creator><creator>Hrabrich, Barbara</creator><creator>Lilie, Nell L.</creator><creator>Martin, Richard A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197511</creationdate><title>Scopolamine effects on delayed spatial alternation in the rat</title><author>Heise, George A. ; Hrabrich, Barbara ; Lilie, Nell L. ; Martin, Richard A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-ea334c4028b4c08a7d624efb329a4ff91f5e0cda95f1f7902fb18e33a8acdd5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Cholinergic blockers</topic><topic>Conditioning, Operant - drug effects</topic><topic>d-Amphetamine</topic><topic>Delayed spatial alternation</topic><topic>Dextroamphetamine - pharmacology</topic><topic>Discrimination (Psychology) - drug effects</topic><topic>Discrimination Learning - drug effects</topic><topic>Male</topic><topic>Perseveration</topic><topic>Rats</topic><topic>Scopolamine</topic><topic>Scopolamine - pharmacology</topic><topic>Scopolamine Derivatives</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heise, George A.</creatorcontrib><creatorcontrib>Hrabrich, Barbara</creatorcontrib><creatorcontrib>Lilie, Nell L.</creatorcontrib><creatorcontrib>Martin, Richard A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heise, George A.</au><au>Hrabrich, Barbara</au><au>Lilie, Nell L.</au><au>Martin, Richard A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scopolamine effects on delayed spatial alternation in the rat</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>1975-11</date><risdate>1975</risdate><volume>3</volume><issue>6</issue><spage>993</spage><epage>1002</epage><pages>993-1002</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><abstract>Rats were trained to press two levers in alternation on discrete trials spaced 10 sec apart. During the final sessions of alternation training, error responses per opportunity on the trials that followed reinforced trials (initial trials) did not differ from error responses per opportunity on repetitive (correction) trials (Experiment 1). Scopolamine did not increase the rats' tendency to perseverate: drug treatment did not cause the error responses per opportunity to increase over runs of consecutive error responses (Experiment 2). Scopolamine did not impair performance when alternation was controlled by visual stimuli present in the external environment at the time of the response (Experiment 3). 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| ispartof | Pharmacology, biochemistry and behavior, 1975-11, Vol.3 (6), p.993-1002 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Atropine - pharmacology Cholinergic blockers Conditioning, Operant - drug effects d-Amphetamine Delayed spatial alternation Dextroamphetamine - pharmacology Discrimination (Psychology) - drug effects Discrimination Learning - drug effects Male Perseveration Rats Scopolamine Scopolamine - pharmacology Scopolamine Derivatives Time Factors |
| title | Scopolamine effects on delayed spatial alternation in the rat |
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