Genital Infection of Female Hamsters with Herpesvirus Hominis Type 2 (HVH-2)
Summary Intravaginal inoculation of female hamsters (40-65 g) with HVH-2 (6 × 105 PFU) results in an infection of 40-67% of the animals. The illness is characterized by vaginitis with discharge, paralysis, and finally death. Washing the vagina with saline 30 min prior to virus inoculation enhances t...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1975-12, Vol.150 (3), p.723-727 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 150 |
| creator | Renis, Harold E. |
| description | Summary
Intravaginal inoculation of female hamsters (40-65 g) with HVH-2 (6 × 105 PFU) results in an infection of 40-67% of the animals. The illness is characterized by vaginitis with discharge, paralysis, and finally death. Washing the vagina with saline 30 min prior to virus inoculation enhances the infection so that 80-100% of the animals eventually die. Virus can be isolated from the vagina within 1-2 days after inoculation. Evidence of infection of the spinal cord is apparent by the third day whereas virus could not be isolated from the brain until Day 5. Attempts to demonstrate virus in whole blood, spleen, kidney, or liver homogenates prepared from infected animals were negative.
The excellent technical assistance of E. B. Swynenberg is gratefully acknowledged. |
| doi_str_mv | 10.3181/00379727-150-39114 |
| format | Article |
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Intravaginal inoculation of female hamsters (40-65 g) with HVH-2 (6 × 105 PFU) results in an infection of 40-67% of the animals. The illness is characterized by vaginitis with discharge, paralysis, and finally death. Washing the vagina with saline 30 min prior to virus inoculation enhances the infection so that 80-100% of the animals eventually die. Virus can be isolated from the vagina within 1-2 days after inoculation. Evidence of infection of the spinal cord is apparent by the third day whereas virus could not be isolated from the brain until Day 5. Attempts to demonstrate virus in whole blood, spleen, kidney, or liver homogenates prepared from infected animals were negative.
The excellent technical assistance of E. B. Swynenberg is gratefully acknowledged.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-150-39114</identifier><identifier>PMID: 174142</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Animals ; Brain - microbiology ; Cricetinae ; Disease Models, Animal ; Female ; Herpes Simplex - etiology ; Herpesviridae Infections - mortality ; Simplexvirus - growth & development ; Simplexvirus - isolation & purification ; Spinal Cord - microbiology ; Time Factors ; Vaginal Diseases - etiology ; Vaginal Diseases - microbiology ; Vaginitis - etiology ; Vaginitis - microbiology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1975-12, Vol.150 (3), p.723-727</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-e5b3b200eeb552fbe94dc4a344dc75ff99d651ef5554e8bc1a1b13d2100c12233</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/174142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Renis, Harold E.</creatorcontrib><title>Genital Infection of Female Hamsters with Herpesvirus Hominis Type 2 (HVH-2)</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Intravaginal inoculation of female hamsters (40-65 g) with HVH-2 (6 × 105 PFU) results in an infection of 40-67% of the animals. The illness is characterized by vaginitis with discharge, paralysis, and finally death. Washing the vagina with saline 30 min prior to virus inoculation enhances the infection so that 80-100% of the animals eventually die. Virus can be isolated from the vagina within 1-2 days after inoculation. Evidence of infection of the spinal cord is apparent by the third day whereas virus could not be isolated from the brain until Day 5. Attempts to demonstrate virus in whole blood, spleen, kidney, or liver homogenates prepared from infected animals were negative.
The excellent technical assistance of E. B. Swynenberg is gratefully acknowledged.</description><subject>Animals</subject><subject>Brain - microbiology</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Herpes Simplex - etiology</subject><subject>Herpesviridae Infections - mortality</subject><subject>Simplexvirus - growth & development</subject><subject>Simplexvirus - isolation & purification</subject><subject>Spinal Cord - microbiology</subject><subject>Time Factors</subject><subject>Vaginal Diseases - etiology</subject><subject>Vaginal Diseases - microbiology</subject><subject>Vaginitis - etiology</subject><subject>Vaginitis - microbiology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS3EqxT-AGLwhGAI9fWjaUZU0aZSJZbCajnJNRjlUewE1H9P-kBsTHc43znS_Qi5BvYgYAIjxkScxDyOQLFIJADyiAxACRWJcZIck8EWiLbEObkI4YMxUDEfn5FTiCVIPiDLOdauNSVd1Bbz1jU1bSydYWVKpKmpQos-0G_XvtMU_RrDl_NdoGlTudoFutqskXJ6l76mEb-_JCfWlAGvDndIXmZPq2kaLZ_ni-njMsqFiNsIVSYyzhhiphS3GSayyKURsj-xsjZJirECtEopiZMsBwMZiIIDYzlwLsSQ3O5317757DC0unIhx7I0NTZd0BMBsZACepDvwdw3IXi0eu1dZfxGA9Nbg_rXoO4N6p3BvnRzWO-yCou_yk5ZH4_2cTBvqD-aztf9r_8N_gDu2ndq</recordid><startdate>197512</startdate><enddate>197512</enddate><creator>Renis, Harold E.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197512</creationdate><title>Genital Infection of Female Hamsters with Herpesvirus Hominis Type 2 (HVH-2)</title><author>Renis, Harold E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-e5b3b200eeb552fbe94dc4a344dc75ff99d651ef5554e8bc1a1b13d2100c12233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Brain - microbiology</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Herpes Simplex - etiology</topic><topic>Herpesviridae Infections - mortality</topic><topic>Simplexvirus - growth & development</topic><topic>Simplexvirus - isolation & purification</topic><topic>Spinal Cord - microbiology</topic><topic>Time Factors</topic><topic>Vaginal Diseases - etiology</topic><topic>Vaginal Diseases - microbiology</topic><topic>Vaginitis - etiology</topic><topic>Vaginitis - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Renis, Harold E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Renis, Harold E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genital Infection of Female Hamsters with Herpesvirus Hominis Type 2 (HVH-2)</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1975-12</date><risdate>1975</risdate><volume>150</volume><issue>3</issue><spage>723</spage><epage>727</epage><pages>723-727</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Intravaginal inoculation of female hamsters (40-65 g) with HVH-2 (6 × 105 PFU) results in an infection of 40-67% of the animals. The illness is characterized by vaginitis with discharge, paralysis, and finally death. Washing the vagina with saline 30 min prior to virus inoculation enhances the infection so that 80-100% of the animals eventually die. Virus can be isolated from the vagina within 1-2 days after inoculation. Evidence of infection of the spinal cord is apparent by the third day whereas virus could not be isolated from the brain until Day 5. Attempts to demonstrate virus in whole blood, spleen, kidney, or liver homogenates prepared from infected animals were negative.
The excellent technical assistance of E. B. Swynenberg is gratefully acknowledged.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>174142</pmid><doi>10.3181/00379727-150-39114</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1975-12, Vol.150 (3), p.723-727 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Brain - microbiology Cricetinae Disease Models, Animal Female Herpes Simplex - etiology Herpesviridae Infections - mortality Simplexvirus - growth & development Simplexvirus - isolation & purification Spinal Cord - microbiology Time Factors Vaginal Diseases - etiology Vaginal Diseases - microbiology Vaginitis - etiology Vaginitis - microbiology |
| title | Genital Infection of Female Hamsters with Herpesvirus Hominis Type 2 (HVH-2) |
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