Mechanisms of antibody formation: II. Use of DNP-Ficoll in studies of hapten-specific B-cell responses

Mice injected with 10 μg N ϵ -dinitrophenyl- l-lysine-Ficoll (DNP-F) preparations ranging widely in epitope density (DNP 52-F to DNP 11.5-F) generated longlasting (6 months) anti-TNP IgM and IgG responses, as measured by the number of spleen PFC produced against sRBC-TNP or hRBC-TNP. The immunogenic...

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Veröffentlicht in:	Cellular immunology 1975-11, Vol.20 (1), p.42-53
Hauptverfasser:	McMaster, P.R.B., Bachvaroff, R.J., Rapaport, F.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - drug effects Antibody Specificity B-Lymphocytes - immunology Dinitrophenols - immunology Dose-Response Relationship, Drug Ficoll - immunology Haptens Hemolytic Plaque Technique Immunoglobulin G - analysis Immunoglobulin M - analysis In Vitro Techniques Mice Mice, Inbred C57BL Polysaccharides - immunology Vinblastine - pharmacology
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