Herpes genitalis in guinea-pigs. I. Kinetic study in infection with Herpesvirus hominis type 2
The kinetics of virus replication after vaginal infection of guinea-pigs with HVH 2/Angelotti were studied in relation to the appearance of local and general symptoms. Most virus was isolated from the genital tract 24-48 hours post infection. Virus was first isolated from the spinal cord 48-72 hours...
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| Veröffentlicht in: | Archives of virology 1975, Vol.41 (1), p.1-11 |
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| creator | Lukás, B Wiesendanger, W Schmidt-Ruppin, K H |
| description | The kinetics of virus replication after vaginal infection of guinea-pigs with HVH 2/Angelotti were studied in relation to the appearance of local and general symptoms. Most virus was isolated from the genital tract 24-48 hours post infection. Virus was first isolated from the spinal cord 48-72 hours post infection. Penetration into the brain only occurred occasionally, and later. Under the experimental conditions employed, no virus was found in the blood, spleen, kidneys, adrenals or inguinal lymph nodes. The local symptoms (typical genital herpes) and the general symptoms (paralysis and death) started after maximum virus replication had been reached and seemed to be a consequence of neural, rather than of haematogenic or lymphogenic spread. |
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Kinetic study in infection with Herpesvirus hominis type 2</title><source>MEDLINE</source><source>Springer Journals</source><creator>Lukás, B ; Wiesendanger, W ; Schmidt-Ruppin, K H</creator><creatorcontrib>Lukás, B ; Wiesendanger, W ; Schmidt-Ruppin, K H</creatorcontrib><description>The kinetics of virus replication after vaginal infection of guinea-pigs with HVH 2/Angelotti were studied in relation to the appearance of local and general symptoms. Most virus was isolated from the genital tract 24-48 hours post infection. Virus was first isolated from the spinal cord 48-72 hours post infection. Penetration into the brain only occurred occasionally, and later. Under the experimental conditions employed, no virus was found in the blood, spleen, kidneys, adrenals or inguinal lymph nodes. The local symptoms (typical genital herpes) and the general symptoms (paralysis and death) started after maximum virus replication had been reached and seemed to be a consequence of neural, rather than of haematogenic or lymphogenic spread.</description><identifier>ISSN: 0304-8608</identifier><identifier>PMID: 172946</identifier><language>eng</language><publisher>Austria</publisher><subject>Animals ; Disease Models, Animal ; Female ; Genital Diseases, Female - microbiology ; Herpes Simplex - microbiology ; Herpes Simplex - transmission ; Male ; Simplexvirus - growth & development ; Simplexvirus - isolation & purification ; Spinal Cord - microbiology ; Uterus - microbiology ; Vagina - microbiology ; Virus Replication</subject><ispartof>Archives of virology, 1975, Vol.41 (1), p.1-11</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/172946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lukás, B</creatorcontrib><creatorcontrib>Wiesendanger, W</creatorcontrib><creatorcontrib>Schmidt-Ruppin, K H</creatorcontrib><title>Herpes genitalis in guinea-pigs. I. Kinetic study in infection with Herpesvirus hominis type 2</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><description>The kinetics of virus replication after vaginal infection of guinea-pigs with HVH 2/Angelotti were studied in relation to the appearance of local and general symptoms. Most virus was isolated from the genital tract 24-48 hours post infection. Virus was first isolated from the spinal cord 48-72 hours post infection. Penetration into the brain only occurred occasionally, and later. Under the experimental conditions employed, no virus was found in the blood, spleen, kidneys, adrenals or inguinal lymph nodes. The local symptoms (typical genital herpes) and the general symptoms (paralysis and death) started after maximum virus replication had been reached and seemed to be a consequence of neural, rather than of haematogenic or lymphogenic spread.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Female</subject><subject>Genital Diseases, Female - microbiology</subject><subject>Herpes Simplex - microbiology</subject><subject>Herpes Simplex - transmission</subject><subject>Male</subject><subject>Simplexvirus - growth & development</subject><subject>Simplexvirus - isolation & purification</subject><subject>Spinal Cord - microbiology</subject><subject>Uterus - microbiology</subject><subject>Vagina - microbiology</subject><subject>Virus Replication</subject><issn>0304-8608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMtOwzAQRb3gVQp_wMIrdqnGdu04S1QBrajEpmsi04zTQYkTYgfUvyeoXY3u1dGR7lywGShYZtaAvWG3MX4BTIXS1-xK5LJYmhn7WOPQY-Q1Bkquocgp8HqkgC7rqY4Lvlnwtykm2vOYxur4D1DwuE_UBf5L6cBPjh8axsgPXUth0qRjj1zesUvvmoj35ztnu5fn3Wqdbd9fN6unbdZraTKtReGkQAdLiwVoXXihtJc5CrBeeoVgjCqsMq4SOaCcRkgNhakqA74Sas4eT9p-6L5HjKlsKe6xaVzAboylVcIYK2ACH87g-NliVfYDtW44lqd3qD_LDVlw</recordid><startdate>1975</startdate><enddate>1975</enddate><creator>Lukás, B</creator><creator>Wiesendanger, W</creator><creator>Schmidt-Ruppin, K H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1975</creationdate><title>Herpes genitalis in guinea-pigs. I. Kinetic study in infection with Herpesvirus hominis type 2</title><author>Lukás, B ; Wiesendanger, W ; Schmidt-Ruppin, K H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p526-5519a21ea048e90559f135f27e108f2f3e06639836ad170e230325096dd60fd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Female</topic><topic>Genital Diseases, Female - microbiology</topic><topic>Herpes Simplex - microbiology</topic><topic>Herpes Simplex - transmission</topic><topic>Male</topic><topic>Simplexvirus - growth & development</topic><topic>Simplexvirus - isolation & purification</topic><topic>Spinal Cord - microbiology</topic><topic>Uterus - microbiology</topic><topic>Vagina - microbiology</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lukás, B</creatorcontrib><creatorcontrib>Wiesendanger, W</creatorcontrib><creatorcontrib>Schmidt-Ruppin, K H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lukás, B</au><au>Wiesendanger, W</au><au>Schmidt-Ruppin, K H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Herpes genitalis in guinea-pigs. I. Kinetic study in infection with Herpesvirus hominis type 2</atitle><jtitle>Archives of virology</jtitle><addtitle>Arch Virol</addtitle><date>1975</date><risdate>1975</risdate><volume>41</volume><issue>1</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>0304-8608</issn><abstract>The kinetics of virus replication after vaginal infection of guinea-pigs with HVH 2/Angelotti were studied in relation to the appearance of local and general symptoms. Most virus was isolated from the genital tract 24-48 hours post infection. Virus was first isolated from the spinal cord 48-72 hours post infection. Penetration into the brain only occurred occasionally, and later. Under the experimental conditions employed, no virus was found in the blood, spleen, kidneys, adrenals or inguinal lymph nodes. The local symptoms (typical genital herpes) and the general symptoms (paralysis and death) started after maximum virus replication had been reached and seemed to be a consequence of neural, rather than of haematogenic or lymphogenic spread.</abstract><cop>Austria</cop><pmid>172946</pmid><tpages>11</tpages></addata></record> |
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| identifier | ISSN: 0304-8608 |
| ispartof | Archives of virology, 1975, Vol.41 (1), p.1-11 |
| issn | 0304-8608 |
| language | eng |
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| source | MEDLINE; Springer Journals |
| subjects | Animals Disease Models, Animal Female Genital Diseases, Female - microbiology Herpes Simplex - microbiology Herpes Simplex - transmission Male Simplexvirus - growth & development Simplexvirus - isolation & purification Spinal Cord - microbiology Uterus - microbiology Vagina - microbiology Virus Replication |
| title | Herpes genitalis in guinea-pigs. I. Kinetic study in infection with Herpesvirus hominis type 2 |
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