Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates
IT is well documented that barbiturates dramatically prolong presynaptic inhibition 1–4 . Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites 5–7 . Since the inhibitory postsynaptic potentials (i.p.s.p.s)...
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| Veröffentlicht in: | Nature (London) 1975-12, Vol.258 (5536), p.625-627 |
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| creator | NICOLL, R. A ECCLES, J. C OSHIMA, T RUBIA, F |
| description | IT is well documented that barbiturates dramatically prolong presynaptic inhibition
1–4
. Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites
5–7
. Since the inhibitory postsynaptic potentials (i.p.s.p.s) in hippocampal neurones are unusually large and the neurones are readily penetrable by microelectrodes
8
, we have studied the effect of barbiturates on these i.p.s.p.s in detail. We have found that barbiturates hyperpolarise hippocampal neurones and markedly prolong the i.p.s.p. by a direct action on inhibitory synapses, anaesthetic doses increasing the duration fivefold. The hyperpolarising action of barbiturates and their effect on i.p.s.p.s would both contribute to the neural depressant action of these anaesthetic agents. |
| doi_str_mv | 10.1038/258625a0 |
| format | Article |
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1–4
. Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites
5–7
. Since the inhibitory postsynaptic potentials (i.p.s.p.s) in hippocampal neurones are unusually large and the neurones are readily penetrable by microelectrodes
8
, we have studied the effect of barbiturates on these i.p.s.p.s in detail. We have found that barbiturates hyperpolarise hippocampal neurones and markedly prolong the i.p.s.p. by a direct action on inhibitory synapses, anaesthetic doses increasing the duration fivefold. The hyperpolarising action of barbiturates and their effect on i.p.s.p.s would both contribute to the neural depressant action of these anaesthetic agents.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/258625a0</identifier><identifier>PMID: 1207741</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Cats ; Hippocampus - drug effects ; Hippocampus - physiology ; Humanities and Social Sciences ; letter ; Membrane Potentials - drug effects ; multidisciplinary ; Pentobarbital - pharmacology ; Science ; Synapses - drug effects ; Synapses - physiology ; Time Factors</subject><ispartof>Nature (London), 1975-12, Vol.258 (5536), p.625-627</ispartof><rights>Springer Nature Limited 1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-ca442e05b6462caf0e7ae2702470d3bbfaff4f9d99ee4e24429f40f7b522ce5f3</citedby><cites>FETCH-LOGICAL-c335t-ca442e05b6462caf0e7ae2702470d3bbfaff4f9d99ee4e24429f40f7b522ce5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/258625a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/258625a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1207741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NICOLL, R. A</creatorcontrib><creatorcontrib>ECCLES, J. C</creatorcontrib><creatorcontrib>OSHIMA, T</creatorcontrib><creatorcontrib>RUBIA, F</creatorcontrib><title>Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>IT is well documented that barbiturates dramatically prolong presynaptic inhibition
1–4
. Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites
5–7
. Since the inhibitory postsynaptic potentials (i.p.s.p.s) in hippocampal neurones are unusually large and the neurones are readily penetrable by microelectrodes
8
, we have studied the effect of barbiturates on these i.p.s.p.s in detail. We have found that barbiturates hyperpolarise hippocampal neurones and markedly prolong the i.p.s.p. by a direct action on inhibitory synapses, anaesthetic doses increasing the duration fivefold. The hyperpolarising action of barbiturates and their effect on i.p.s.p.s would both contribute to the neural depressant action of these anaesthetic agents.</description><subject>Animals</subject><subject>Cats</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Membrane Potentials - drug effects</subject><subject>multidisciplinary</subject><subject>Pentobarbital - pharmacology</subject><subject>Science</subject><subject>Synapses - drug effects</subject><subject>Synapses - physiology</subject><subject>Time Factors</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1PwzAQhi0EKqUg8QdAmRAMgYvjxMmIKr6kChhgjpz03LpK7WA7Q_49RillYTrdvY9e6R5CzhO4TSAt7mhW5DQTcECmCeN5zPKCH5IpAC1iKNL8mJw4twGALOFsQiYJBc5ZMiWv79a0Rq-EV0ZHRkZr1XWmEdtOtJHSa1Urb-wQdcZ5N2jRedWExaP2SrQuqoeoFjZAvRUe3Sk5kuGMZ7s5I5-PDx_z53jx9vQyv1_ETZpmPm4EYxQhq3OW00ZIQC6QcqCMwzKtaymkZLJcliUiQxrgUjKQvM4obTCT6Yxcjb2dNV89Ol9tlWuwbYVG07uqSJM8hzIN4PUINtY4Z1FWnVVbYYcqgepHXfWrLqAXu86-3uLyDxxdhfxmzF1I9ApttTG91eHN_7ouR1aLYAb3XXvgG_b_ghc</recordid><startdate>19751218</startdate><enddate>19751218</enddate><creator>NICOLL, R. A</creator><creator>ECCLES, J. C</creator><creator>OSHIMA, T</creator><creator>RUBIA, F</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19751218</creationdate><title>Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates</title><author>NICOLL, R. A ; ECCLES, J. C ; OSHIMA, T ; RUBIA, F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-ca442e05b6462caf0e7ae2702470d3bbfaff4f9d99ee4e24429f40f7b522ce5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Cats</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Membrane Potentials - drug effects</topic><topic>multidisciplinary</topic><topic>Pentobarbital - pharmacology</topic><topic>Science</topic><topic>Synapses - drug effects</topic><topic>Synapses - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NICOLL, R. A</creatorcontrib><creatorcontrib>ECCLES, J. C</creatorcontrib><creatorcontrib>OSHIMA, T</creatorcontrib><creatorcontrib>RUBIA, F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NICOLL, R. A</au><au>ECCLES, J. C</au><au>OSHIMA, T</au><au>RUBIA, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1975-12-18</date><risdate>1975</risdate><volume>258</volume><issue>5536</issue><spage>625</spage><epage>627</epage><pages>625-627</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>IT is well documented that barbiturates dramatically prolong presynaptic inhibition
1–4
. Their effect on postsynaptic inhibition is less clear, although the available evidence suggests that a similar enhancement may occur at some sites
5–7
. Since the inhibitory postsynaptic potentials (i.p.s.p.s) in hippocampal neurones are unusually large and the neurones are readily penetrable by microelectrodes
8
, we have studied the effect of barbiturates on these i.p.s.p.s in detail. We have found that barbiturates hyperpolarise hippocampal neurones and markedly prolong the i.p.s.p. by a direct action on inhibitory synapses, anaesthetic doses increasing the duration fivefold. The hyperpolarising action of barbiturates and their effect on i.p.s.p.s would both contribute to the neural depressant action of these anaesthetic agents.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>1207741</pmid><doi>10.1038/258625a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1975-12, Vol.258 (5536), p.625-627 |
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| language | eng |
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| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Animals Cats Hippocampus - drug effects Hippocampus - physiology Humanities and Social Sciences letter Membrane Potentials - drug effects multidisciplinary Pentobarbital - pharmacology Science Synapses - drug effects Synapses - physiology Time Factors |
| title | Prolongation of hippocampal inhibitory postsynaptic potentials by barbiturates |
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