Depletion of antral gastrin after food in rats

The results of these studies indicate that in fasting rats, there is an abrupt and prolonged rise in circulating gastrin after feeding. This increase in serum gastrin is accompanied by an early (five minutes) diminution in antral gastrin which is followed by slightly higher and more variable antral...

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Veröffentlicht in:The American journal of surgery 1975, Vol.129 (1), p.67-70
Hauptverfasser: Reeder, David D., Watayou, Takaho, Booth, Robert A.D., Thompson, James C.
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container_title The American journal of surgery
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creator Reeder, David D.
Watayou, Takaho
Booth, Robert A.D.
Thompson, James C.
description The results of these studies indicate that in fasting rats, there is an abrupt and prolonged rise in circulating gastrin after feeding. This increase in serum gastrin is accompanied by an early (five minutes) diminution in antral gastrin which is followed by slightly higher and more variable antral gastrin values. These findings suggest that feeding triggers the release of gastrin with early depletion of antral gastrin and that, subsequently, gastrin synthesis and release interact cyclically to maintain antral and serum concentrations of gastrin. Antral, fundic, and duodenal gastrin values in rats are similar to those reported in dogs and cats. The jejunum of the rat contains little, if any, gastrin.
doi_str_mv 10.1016/0002-9610(75)90169-5
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subjects Animals
Duodenum - analysis
Eating
Fasting
Gastric Mucosa - analysis
Gastrins - analysis
Jejunum - analysis
Pyloric Antrum - analysis
Radioimmunoassay
Rats
title Depletion of antral gastrin after food in rats
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