Growth kinetics of human large bowel cancer growing in immune‐deprived mice and some chemotherapeutic observations
Xenografts of human large bowel cancer have been grown in immune‐deprived mice. Studies have been made of their intermitotic time and other proliferative characteristics, and their response to single doses of a number of chemotherapeutic agents has been measured. The indcations from this study are t...
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| Veröffentlicht in: | Cancer 1975-12, Vol.36 (S6), p.2431-2436 |
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| container_issue | S6 |
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| container_title | Cancer |
| container_volume | 36 |
| creator | Lamerton, L. F. Steel, G. G. |
| description | Xenografts of human large bowel cancer have been grown in immune‐deprived mice. Studies have been made of their intermitotic time and other proliferative characteristics, and their response to single doses of a number of chemotherapeutic agents has been measured. The indcations from this study are that, although the growth rate of xenografts is much faster than that for tumors in man, this is likely to be due largely to a difference in rate of cell loss, and the intermitotic time and growth fraction may not have changed substantially. The spectrum of response to chemotherapeutic agents is in line with clinical experience and, although there are many uncertainties and problems still to be resolved, it is indicated that xenografts could provide a useful experimental system for the laboratory study of the chemotherapy of large bowel cancer. |
| doi_str_mv | 10.1002/1097-0142(197512)36:6<2431::AID-CNCR2820360625>3.0.CO;2-W |
| format | Article |
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The spectrum of response to chemotherapeutic agents is in line with clinical experience and, although there are many uncertainties and problems still to be resolved, it is indicated that xenografts could provide a useful experimental system for the laboratory study of the chemotherapy of large bowel cancer.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(197512)36:6<2431::AID-CNCR2820360625>3.0.CO;2-W</identifier><identifier>PMID: 1212661</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Carcinoma - pathology ; Cell Count ; Cell Line ; Colonic Neoplasms - drug therapy ; Colonic Neoplasms - immunology ; Colonic Neoplasms - pathology ; Female ; Humans ; Immunity - drug effects ; Immunologic Deficiency Syndromes - pathology ; Kinetics ; Male ; Mice ; Mice, Inbred CBA ; Mitosis ; Neoplasm Transplantation ; Neoplasms, Experimental - pathology ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - immunology ; Rectal Neoplasms - pathology ; Transplantation, Heterologous</subject><ispartof>Cancer, 1975-12, Vol.36 (S6), p.2431-2436</ispartof><rights>Copyright © 1975 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3815-6a4b43cf5414ddeea3155296cd947dd98ee1708b2485564df956deee8fab5b443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1212661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lamerton, L. F.</creatorcontrib><creatorcontrib>Steel, G. G.</creatorcontrib><title>Growth kinetics of human large bowel cancer growing in immune‐deprived mice and some chemotherapeutic observations</title><title>Cancer</title><addtitle>Cancer</addtitle><description>Xenografts of human large bowel cancer have been grown in immune‐deprived mice. Studies have been made of their intermitotic time and other proliferative characteristics, and their response to single doses of a number of chemotherapeutic agents has been measured. The indcations from this study are that, although the growth rate of xenografts is much faster than that for tumors in man, this is likely to be due largely to a difference in rate of cell loss, and the intermitotic time and growth fraction may not have changed substantially. The spectrum of response to chemotherapeutic agents is in line with clinical experience and, although there are many uncertainties and problems still to be resolved, it is indicated that xenografts could provide a useful experimental system for the laboratory study of the chemotherapy of large bowel cancer.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Carcinoma - pathology</subject><subject>Cell Count</subject><subject>Cell Line</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Colonic Neoplasms - immunology</subject><subject>Colonic Neoplasms - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunity - drug effects</subject><subject>Immunologic Deficiency Syndromes - pathology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Mitosis</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - immunology</subject><subject>Rectal Neoplasms - pathology</subject><subject>Transplantation, Heterologous</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkd-K1DAUxoso67j6CEKuRC865n_TUYSh6rqwOCDK6lVIk9OZatuMSbvD3vkIPqNPYoYuil4IXh0O35fvnJxflq0JXhKM6VOCyyLHhNPHpCwEoU-YXMnnlDOyWq3PX-bV2-odVRQziSUVL9gSL6vNM5pf3soWv97ezhYYY5ULzj7eze7F-Dm1BRXsJDshlFApySIbz4I_jDv0pR1gbG1EvkG7qTcD6kzYAqr9ATpkzWAhoG3ytsMWtQNq-34a4Me37w72ob0Ch_rWAjKDQ9H3gOwOej_uIJg9TCkY-TpCuDJj64d4P7vTmC7Cg5t6mn14_ep99Sa_2JydV-uL3DJFRC4NrzmzjeCEOwdgGBGCltK6khfOlQqAFFjVlCshJHdNKWSygWpMLWrO2Wn2aM7dB_91gjjqvo0Wus4M4KeoVQrkSrFk_DQbbfAxBmh0-lRvwrUmWB-J6ONV9fGqeiaimdRSH4lonYjoP4loprGuNprqy5T98GaJqe7B_U6eESTdzfqh7eD6fwb_c-5fCvsJRH6rxg</recordid><startdate>197512</startdate><enddate>197512</enddate><creator>Lamerton, L. F.</creator><creator>Steel, G. G.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197512</creationdate><title>Growth kinetics of human large bowel cancer growing in immune‐deprived mice and some chemotherapeutic observations</title><author>Lamerton, L. F. ; Steel, G. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3815-6a4b43cf5414ddeea3155296cd947dd98ee1708b2485564df956deee8fab5b443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Carcinoma - pathology</topic><topic>Cell Count</topic><topic>Cell Line</topic><topic>Colonic Neoplasms - drug therapy</topic><topic>Colonic Neoplasms - immunology</topic><topic>Colonic Neoplasms - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunity - drug effects</topic><topic>Immunologic Deficiency Syndromes - pathology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Mitosis</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - immunology</topic><topic>Rectal Neoplasms - pathology</topic><topic>Transplantation, Heterologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lamerton, L. F.</creatorcontrib><creatorcontrib>Steel, G. G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lamerton, L. F.</au><au>Steel, G. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth kinetics of human large bowel cancer growing in immune‐deprived mice and some chemotherapeutic observations</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1975-12</date><risdate>1975</risdate><volume>36</volume><issue>S6</issue><spage>2431</spage><epage>2436</epage><pages>2431-2436</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>Xenografts of human large bowel cancer have been grown in immune‐deprived mice. Studies have been made of their intermitotic time and other proliferative characteristics, and their response to single doses of a number of chemotherapeutic agents has been measured. The indcations from this study are that, although the growth rate of xenografts is much faster than that for tumors in man, this is likely to be due largely to a difference in rate of cell loss, and the intermitotic time and growth fraction may not have changed substantially. The spectrum of response to chemotherapeutic agents is in line with clinical experience and, although there are many uncertainties and problems still to be resolved, it is indicated that xenografts could provide a useful experimental system for the laboratory study of the chemotherapy of large bowel cancer.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1212661</pmid><doi>10.1002/1097-0142(197512)36:6<2431::AID-CNCR2820360625>3.0.CO;2-W</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cancer, 1975-12, Vol.36 (S6), p.2431-2436 |
| issn | 0008-543X 1097-0142 |
| language | eng |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carcinoma - pathology Cell Count Cell Line Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - pathology Female Humans Immunity - drug effects Immunologic Deficiency Syndromes - pathology Kinetics Male Mice Mice, Inbred CBA Mitosis Neoplasm Transplantation Neoplasms, Experimental - pathology Rectal Neoplasms - drug therapy Rectal Neoplasms - immunology Rectal Neoplasms - pathology Transplantation, Heterologous |
| title | Growth kinetics of human large bowel cancer growing in immune‐deprived mice and some chemotherapeutic observations |
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