Serum protein fractionation in gynecologic malignancy
Serum protein fractionation using paper electrophoresis was determined in 73 patients with uterine cancer. The distribution of the serum proteins was found to be abnormal. Hypoalbuminemia occurred in all patients studied, including those with noninvasive and clinically localized cancer. Total protei...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1962-11, Vol.84 (9), p.1177-1195 |
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| container_end_page | 1195 |
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| container_issue | 9 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 84 |
| creator | de Alvarez, Russell R. Madenwald, Malcolm B. Namkung, Pearl C. |
| description | Serum protein fractionation using paper electrophoresis was determined in 73 patients with uterine cancer. The distribution of the serum proteins was found to be abnormal.
Hypoalbuminemia occurred in all patients studied, including those with noninvasive and clinically localized cancer.
Total protein remained unchanged, indicating an absolute increase in total globulin. The alpha-2 and beta globulins exhibited the greatest increases in the malignancies studied.
The serum protein changes in the albumin, alpha-2, and beta fractions are similar in pregnancy and in uterine cancer. Electrophoretic separation of the alpha-1 and gamma globulin fraction in gynecologic cancer reveal no significant difference from normal values. |
| doi_str_mv | 10.1016/0002-9378(62)90510-0 |
| format | Article |
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Hypoalbuminemia occurred in all patients studied, including those with noninvasive and clinically localized cancer.
Total protein remained unchanged, indicating an absolute increase in total globulin. The alpha-2 and beta globulins exhibited the greatest increases in the malignancies studied.
The serum protein changes in the albumin, alpha-2, and beta fractions are similar in pregnancy and in uterine cancer. Electrophoretic separation of the alpha-1 and gamma globulin fraction in gynecologic cancer reveal no significant difference from normal values.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(62)90510-0</identifier><identifier>PMID: 14025663</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blood Protein Electrophoresis ; Blood Proteins ; Female ; Genital Neoplasms, Female ; Humans ; Old Medline ; Pregnancy</subject><ispartof>American journal of obstetrics and gynecology, 1962-11, Vol.84 (9), p.1177-1195</ispartof><rights>1962</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-21706731e8d3f7e9672837888f16cea78b77a3b316d62058fc93fdaecaf2d1d43</citedby><cites>FETCH-LOGICAL-c275t-21706731e8d3f7e9672837888f16cea78b77a3b316d62058fc93fdaecaf2d1d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937862905100$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14025663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Alvarez, Russell R.</creatorcontrib><creatorcontrib>Madenwald, Malcolm B.</creatorcontrib><creatorcontrib>Namkung, Pearl C.</creatorcontrib><title>Serum protein fractionation in gynecologic malignancy</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Serum protein fractionation using paper electrophoresis was determined in 73 patients with uterine cancer. The distribution of the serum proteins was found to be abnormal.
Hypoalbuminemia occurred in all patients studied, including those with noninvasive and clinically localized cancer.
Total protein remained unchanged, indicating an absolute increase in total globulin. The alpha-2 and beta globulins exhibited the greatest increases in the malignancies studied.
The serum protein changes in the albumin, alpha-2, and beta fractions are similar in pregnancy and in uterine cancer. Electrophoretic separation of the alpha-1 and gamma globulin fraction in gynecologic cancer reveal no significant difference from normal values.</description><subject>Blood Protein Electrophoresis</subject><subject>Blood Proteins</subject><subject>Female</subject><subject>Genital Neoplasms, Female</subject><subject>Humans</subject><subject>Old Medline</subject><subject>Pregnancy</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKxDAUhoMozjj6BiJdiS6qubRJuhFk8AYDLtR1yCQnQ6SXMWmFvr0pM-jOzfk5h-_cfoTOCb4hmPBbjDHNKybkFafXFS4JzvEBmhNciZxLLg_R_BeZoZMYP6eUVvQYzUiBack5m6PyDcLQZNvQ9eDbzAVtet-1egpZKmzGFkxXdxtvskbXftPq1oyn6MjpOsLZXhfo4_Hhffmcr16fXpb3q9xQUfY5JQJzwQhIy5yAigsq0zVSOsINaCHXQmi2ZoRbTnEpnamYsxqMdtQSW7AFutzNTfd9DRB71fhooK51C90QlWSkYLSQCSx2oAldjAGc2gbf6DAqgtVkl5qeV5MXiied7FI4tV3s5w_rBuxf096fBNztAEhffnsIKhoPrQHrA5he2c7_v-EHpvR4zA</recordid><startdate>19621101</startdate><enddate>19621101</enddate><creator>de Alvarez, Russell R.</creator><creator>Madenwald, Malcolm B.</creator><creator>Namkung, Pearl C.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19621101</creationdate><title>Serum protein fractionation in gynecologic malignancy</title><author>de Alvarez, Russell R. ; Madenwald, Malcolm B. ; Namkung, Pearl C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-21706731e8d3f7e9672837888f16cea78b77a3b316d62058fc93fdaecaf2d1d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Blood Protein Electrophoresis</topic><topic>Blood Proteins</topic><topic>Female</topic><topic>Genital Neoplasms, Female</topic><topic>Humans</topic><topic>Old Medline</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Alvarez, Russell R.</creatorcontrib><creatorcontrib>Madenwald, Malcolm B.</creatorcontrib><creatorcontrib>Namkung, Pearl C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Alvarez, Russell R.</au><au>Madenwald, Malcolm B.</au><au>Namkung, Pearl C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum protein fractionation in gynecologic malignancy</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1962-11-01</date><risdate>1962</risdate><volume>84</volume><issue>9</issue><spage>1177</spage><epage>1195</epage><pages>1177-1195</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Serum protein fractionation using paper electrophoresis was determined in 73 patients with uterine cancer. The distribution of the serum proteins was found to be abnormal.
Hypoalbuminemia occurred in all patients studied, including those with noninvasive and clinically localized cancer.
Total protein remained unchanged, indicating an absolute increase in total globulin. The alpha-2 and beta globulins exhibited the greatest increases in the malignancies studied.
The serum protein changes in the albumin, alpha-2, and beta fractions are similar in pregnancy and in uterine cancer. Electrophoretic separation of the alpha-1 and gamma globulin fraction in gynecologic cancer reveal no significant difference from normal values.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14025663</pmid><doi>10.1016/0002-9378(62)90510-0</doi><tpages>19</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1962-11, Vol.84 (9), p.1177-1195 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood Protein Electrophoresis Blood Proteins Female Genital Neoplasms, Female Humans Old Medline Pregnancy |
| title | Serum protein fractionation in gynecologic malignancy |
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