Effects of Isoproterenol on Carbohydrate Metabolism of Isolated Canine Heart
Chronotropic and inotropic effects of intraarterial infusion of isoproterenol were monitored in the isolated, metabolically supported preparations of the canine heart.The time-dosage relationship was found to be hyperbolic over a narrow range of concentration of isoproterenol. Increasing concentrati...
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| Veröffentlicht in: | Circulation research 1963-01, Vol.12 (1), p.76-84 |
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| container_title | Circulation research |
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| creator | Winterscheid, Loren C Bruce, Robert A Blumberg, Jack B Merendino, K Alvin |
| description | Chronotropic and inotropic effects of intraarterial infusion of isoproterenol were monitored in the isolated, metabolically supported preparations of the canine heart.The time-dosage relationship was found to be hyperbolic over a narrow range of concentration of isoproterenol. Increasing concentration beyond the optimal range by a factor of about two produced arrhythmias and A-V conduction defects.Oxidative metabolism increased significantly and proportionally to heart rate.Since utilization of glucose remained the same, pyruvate utilization increased slightly and lactate was excreted; the augmented oxidative metabolism could not be accounted for by the observed changes in carbohydrate substrates.Myocardial glycogen concentrations were insignificantly changed during this inotropic stimulation. |
| doi_str_mv | 10.1161/01.RES.12.1.76 |
| format | Article |
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Increasing concentration beyond the optimal range by a factor of about two produced arrhythmias and A-V conduction defects.Oxidative metabolism increased significantly and proportionally to heart rate.Since utilization of glucose remained the same, pyruvate utilization increased slightly and lactate was excreted; the augmented oxidative metabolism could not be accounted for by the observed changes in carbohydrate substrates.Myocardial glycogen concentrations were insignificantly changed during this inotropic stimulation.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.12.1.76</identifier><identifier>PMID: 14001262</identifier><language>eng</language><publisher>United States: American Heart Association, Inc</publisher><subject>Animals ; Carbohydrate Metabolism ; Dogs ; Glucose ; Heart ; Isoproterenol ; Lactates ; Old Medline ; Pyruvates</subject><ispartof>Circulation research, 1963-01, Vol.12 (1), p.76-84</ispartof><rights>1963 American Heart Association, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4112-488ff3a9a5d93cae39c5a31a9fcfca960be6c40d82251e46d67423e3d7c0170e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3673,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14001262$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winterscheid, Loren C</creatorcontrib><creatorcontrib>Bruce, Robert A</creatorcontrib><creatorcontrib>Blumberg, Jack B</creatorcontrib><creatorcontrib>Merendino, K Alvin</creatorcontrib><title>Effects of Isoproterenol on Carbohydrate Metabolism of Isolated Canine Heart</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Chronotropic and inotropic effects of intraarterial infusion of isoproterenol were monitored in the isolated, metabolically supported preparations of the canine heart.The time-dosage relationship was found to be hyperbolic over a narrow range of concentration of isoproterenol. Increasing concentration beyond the optimal range by a factor of about two produced arrhythmias and A-V conduction defects.Oxidative metabolism increased significantly and proportionally to heart rate.Since utilization of glucose remained the same, pyruvate utilization increased slightly and lactate was excreted; the augmented oxidative metabolism could not be accounted for by the observed changes in carbohydrate substrates.Myocardial glycogen concentrations were insignificantly changed during this inotropic stimulation.</description><subject>Animals</subject><subject>Carbohydrate Metabolism</subject><subject>Dogs</subject><subject>Glucose</subject><subject>Heart</subject><subject>Isoproterenol</subject><subject>Lactates</subject><subject>Old Medline</subject><subject>Pyruvates</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1963</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LAzEQhoMotlavHmVP3nbNJNls9yil2kJF8OMc0uyEVtNNTXYp_fdGuuBpPnjeYXgIuQVaAEh4oFC8zd8LYAUUlTwjYyiZyEVZwTkZU0rrvOKcjshVjF-UguCsviQjEKlnko3Jam4tmi5m3mbL6PfBdxiw9S7zbTbTYe03xyboDrMX7PTau23cDaxL2yYx7bbFbIE6dNfkwmoX8WaoE_L5NP-YLfLV6_Ny9rjKjQBguZhOreW61mVTc6OR16bUHHRtjTW6lnSN0gjaTBkrAYVsZCUYR95UhkJFkU_I_eluevenx9ip3TYadE636PuophwEMC4SWJxAE3yMAa3ah-1Oh6MCqv78KQoq-VPAFKhKpsDdcLlf77D5xwdhCRAn4OBdMhW_XX_AoDaoXbdRSTjlCcyhlqmmKad_Qf4L1FJ6aA</recordid><startdate>196301</startdate><enddate>196301</enddate><creator>Winterscheid, Loren C</creator><creator>Bruce, Robert A</creator><creator>Blumberg, Jack B</creator><creator>Merendino, K Alvin</creator><general>American Heart Association, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196301</creationdate><title>Effects of Isoproterenol on Carbohydrate Metabolism of Isolated Canine Heart</title><author>Winterscheid, Loren C ; Bruce, Robert A ; Blumberg, Jack B ; Merendino, K Alvin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4112-488ff3a9a5d93cae39c5a31a9fcfca960be6c40d82251e46d67423e3d7c0170e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1963</creationdate><topic>Animals</topic><topic>Carbohydrate Metabolism</topic><topic>Dogs</topic><topic>Glucose</topic><topic>Heart</topic><topic>Isoproterenol</topic><topic>Lactates</topic><topic>Old Medline</topic><topic>Pyruvates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winterscheid, Loren C</creatorcontrib><creatorcontrib>Bruce, Robert A</creatorcontrib><creatorcontrib>Blumberg, Jack B</creatorcontrib><creatorcontrib>Merendino, K Alvin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winterscheid, Loren C</au><au>Bruce, Robert A</au><au>Blumberg, Jack B</au><au>Merendino, K Alvin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Isoproterenol on Carbohydrate Metabolism of Isolated Canine Heart</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1963-01</date><risdate>1963</risdate><volume>12</volume><issue>1</issue><spage>76</spage><epage>84</epage><pages>76-84</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><abstract>Chronotropic and inotropic effects of intraarterial infusion of isoproterenol were monitored in the isolated, metabolically supported preparations of the canine heart.The time-dosage relationship was found to be hyperbolic over a narrow range of concentration of isoproterenol. Increasing concentration beyond the optimal range by a factor of about two produced arrhythmias and A-V conduction defects.Oxidative metabolism increased significantly and proportionally to heart rate.Since utilization of glucose remained the same, pyruvate utilization increased slightly and lactate was excreted; the augmented oxidative metabolism could not be accounted for by the observed changes in carbohydrate substrates.Myocardial glycogen concentrations were insignificantly changed during this inotropic stimulation.</abstract><cop>United States</cop><pub>American Heart Association, Inc</pub><pmid>14001262</pmid><doi>10.1161/01.RES.12.1.76</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation research, 1963-01, Vol.12 (1), p.76-84 |
| issn | 0009-7330 1524-4571 |
| language | eng |
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| source | MEDLINE; American Heart Association Journals; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Carbohydrate Metabolism Dogs Glucose Heart Isoproterenol Lactates Old Medline Pyruvates |
| title | Effects of Isoproterenol on Carbohydrate Metabolism of Isolated Canine Heart |
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