Immunochemical Evidence for a Common Variable Region in Three Immunoglobulin Classes in the Same Individual

One IgG1(κ ), one IgM(κ ), and one IgA1(κ ) monoclonal (M)-component were purified from one human serum. Rabbit antisera were raised against the IgG and IgM M-components and were absorbed until specific for idiotypic determinants on these molecules. All three M-components gave reactions of immunolog...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1975-10, Vol.72 (10), p.4115-4118
Hauptverfasser:	Grubb, Anders O., Zettervall, Olle H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antiserum Electrophoresis Epitopes Gels Humans Immunodiffusion Immunoglobulin A - analysis Immunoglobulin G - analysis Immunoglobulin M - analysis Immunoglobulins Immunology Lung Neoplasms - blood Lung Neoplasms - immunology Male Molecular chains Molecules Precipitates Water purification
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