Synthesis and Biological Evaluation of Potential Hypoglycemic Agents I: Carnitine Analogs
A series of 4‐dialkylamino‐3‐hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert‐butyl 3, 4‐epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid hydrolysis. The compounds had no effect on blood...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1975-12, Vol.64 (12), p.1949-1952 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| container_end_page | 1952 |
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| container_issue | 12 |
| container_start_page | 1949 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 64 |
| creator | Boots, Sharon G. Boots, Marvin R. |
| description | A series of 4‐dialkylamino‐3‐hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert‐butyl 3, 4‐epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid hydrolysis. The compounds had no effect on blood glucose or serum fatty acid levels in rats. |
| doi_str_mv | 10.1002/jps.2600641208 |
| format | Article |
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The compounds had no effect on blood glucose or serum fatty acid levels in rats.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600641208</identifier><identifier>PMID: 1206486</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; biological evaluation ; Blood Glucose - metabolism ; Carnitine - analogs & derivatives ; Carnitine - pharmacology ; Carnitine analogs-potential hypoglycemic agents ; Carnitine analogs—potential hypoglycemic agents, synthesis, biological evaluation, IR and NMR spectra ; Fatty Acids, Nonesterified - blood ; Hypoglycemic agents ; Hypoglycemic Agents - chemical synthesis ; Hypoglycemic Agents - pharmacology ; Hypoglycemic agents, potential—carnitine analogs, synthesis, biological evaluation, IR and NMR spectra ; IR and NMR spectra ; Male ; potential-carnitine analogs ; Rats ; synthesis</subject><ispartof>Journal of pharmaceutical sciences, 1975-12, Vol.64 (12), p.1949-1952</ispartof><rights>1975 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1975 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3428-fc8bf7446ff8e1e34ce06df7162c6203d9d52562618c241a5ffa6d745d5585753</citedby><cites>FETCH-LOGICAL-c3428-fc8bf7446ff8e1e34ce06df7162c6203d9d52562618c241a5ffa6d745d5585753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600641208$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600641208$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1206486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boots, Sharon G.</creatorcontrib><creatorcontrib>Boots, Marvin R.</creatorcontrib><title>Synthesis and Biological Evaluation of Potential Hypoglycemic Agents I: Carnitine Analogs</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>A series of 4‐dialkylamino‐3‐hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert‐butyl 3, 4‐epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid hydrolysis. The compounds had no effect on blood glucose or serum fatty acid levels in rats.</description><subject>Animals</subject><subject>biological evaluation</subject><subject>Blood Glucose - metabolism</subject><subject>Carnitine - analogs & derivatives</subject><subject>Carnitine - pharmacology</subject><subject>Carnitine analogs-potential hypoglycemic agents</subject><subject>Carnitine analogs—potential hypoglycemic agents, synthesis, biological evaluation, IR and NMR spectra</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Hypoglycemic agents</subject><subject>Hypoglycemic Agents - chemical synthesis</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypoglycemic agents, potential—carnitine analogs, synthesis, biological evaluation, IR and NMR spectra</subject><subject>IR and NMR spectra</subject><subject>Male</subject><subject>potential-carnitine analogs</subject><subject>Rats</subject><subject>synthesis</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFPFDEUhxuiwRW5ejPpydssbaftdL2tKy4YgiQLIXppSud1Lc62SzuLzH9vyRCJB-PpJe99v1_yPoTeUjKlhLCj222eMkmI5JQRtYcmVDBSSUKbF2hSAFbVgs9eodc535KCESH20X5hJVdygr6thtD_gOwzNqHFH33s4tpb0-Hje9PtTO9jwNHhi9hD6H3ZnwzbuO4GCxtv8XxdthmffsALk4LvfQA8D6Z05DfopTNdhsOneYCuPh9fLk6qs6_L08X8rLI1Z6pyVt24hnPpnAIKNbdAZOsaKpmVjNTtrBVMSCapsoxTI5wzsm24aIVQohH1AXo_9m5TvNtB7vXGZwtdZwLEXdaqpqxhnBRwOoI2xZwTOL1NfmPSoCnRjy51camfXZbAu6fm3c0G2md8lFfus_H-y3cw_KdNf7lY_dVdjVmfe3j4kzXpp5ZN3Qh9fb7U598vV3Lxaakfv1QjD0XlvYeks_UQLLQ-ge11G_2_3vgN_PuhtQ</recordid><startdate>197512</startdate><enddate>197512</enddate><creator>Boots, Sharon G.</creator><creator>Boots, Marvin R.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197512</creationdate><title>Synthesis and Biological Evaluation of Potential Hypoglycemic Agents I: Carnitine Analogs</title><author>Boots, Sharon G. ; Boots, Marvin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3428-fc8bf7446ff8e1e34ce06df7162c6203d9d52562618c241a5ffa6d745d5585753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>biological evaluation</topic><topic>Blood Glucose - metabolism</topic><topic>Carnitine - analogs & derivatives</topic><topic>Carnitine - pharmacology</topic><topic>Carnitine analogs-potential hypoglycemic agents</topic><topic>Carnitine analogs—potential hypoglycemic agents, synthesis, biological evaluation, IR and NMR spectra</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Hypoglycemic agents</topic><topic>Hypoglycemic Agents - chemical synthesis</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypoglycemic agents, potential—carnitine analogs, synthesis, biological evaluation, IR and NMR spectra</topic><topic>IR and NMR spectra</topic><topic>Male</topic><topic>potential-carnitine analogs</topic><topic>Rats</topic><topic>synthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boots, Sharon G.</creatorcontrib><creatorcontrib>Boots, Marvin R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boots, Sharon G.</au><au>Boots, Marvin R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Biological Evaluation of Potential Hypoglycemic Agents I: Carnitine Analogs</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1975-12</date><risdate>1975</risdate><volume>64</volume><issue>12</issue><spage>1949</spage><epage>1952</epage><pages>1949-1952</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>A series of 4‐dialkylamino‐3‐hydroxybutyric acid hydrochlorides and methochlorides, analogs of carnitine, was synthesized by treatment of tert‐butyl 3, 4‐epoxybutyrate with the appropriate amine or amine hydrochloride in methanol followed by mild acid hydrolysis. The compounds had no effect on blood glucose or serum fatty acid levels in rats.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>1206486</pmid><doi>10.1002/jps.2600641208</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1975-12, Vol.64 (12), p.1949-1952 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83127240 |
| source | MEDLINE; Alma/SFX Local Collection; Wiley Blackwell Journals |
| subjects | Animals biological evaluation Blood Glucose - metabolism Carnitine - analogs & derivatives Carnitine - pharmacology Carnitine analogs-potential hypoglycemic agents Carnitine analogs—potential hypoglycemic agents, synthesis, biological evaluation, IR and NMR spectra Fatty Acids, Nonesterified - blood Hypoglycemic agents Hypoglycemic Agents - chemical synthesis Hypoglycemic Agents - pharmacology Hypoglycemic agents, potential—carnitine analogs, synthesis, biological evaluation, IR and NMR spectra IR and NMR spectra Male potential-carnitine analogs Rats synthesis |
| title | Synthesis and Biological Evaluation of Potential Hypoglycemic Agents I: Carnitine Analogs |
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