Developments in nitrile and amide biotransformation processes
Nitrile and amide bioconversions have received attention through their ability to provide a range of commercially important chemicals. These bioconversions are mediated by distinct process strategies. Here, the processes performance is discussed, and the use of whole cells, cell extracts and enzymes...
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| Veröffentlicht in: | Trends in biotechnology (Regular ed.) 2010-11, Vol.28 (11), p.561-569 |
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| creator | Velankar, Harshad Clarke, Kim G Preez, Ryne du Cowan, Don A Burton, Stephanie G |
| description | Nitrile and amide bioconversions have received attention through their ability to provide a range of commercially important chemicals. These bioconversions are mediated by distinct process strategies. Here, the processes performance is discussed, and the use of whole cells, cell extracts and enzymes as biocatalysts is compared. Additionally, the benefits of biocatalyst reuse through immobilization have been identified and immobilization matrices utilized for these bioconversions evaluated. Exploitation and commercial development will depend on optimization of the process performance and the capacity for scale-up in addition to the biocatalytic potential. High substrate concentrations and biocatalyst stability and reuse through immobilization strategies provide driving forces towards more efficient process kinetics. Membrane immobilization is specifically highlighted as a route to maximize process performance. |
| doi_str_mv | 10.1016/j.tibtech.2010.08.004 |
| format | Article |
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These bioconversions are mediated by distinct process strategies. Here, the processes performance is discussed, and the use of whole cells, cell extracts and enzymes as biocatalysts is compared. Additionally, the benefits of biocatalyst reuse through immobilization have been identified and immobilization matrices utilized for these bioconversions evaluated. Exploitation and commercial development will depend on optimization of the process performance and the capacity for scale-up in addition to the biocatalytic potential. High substrate concentrations and biocatalyst stability and reuse through immobilization strategies provide driving forces towards more efficient process kinetics. Membrane immobilization is specifically highlighted as a route to maximize process performance.</description><identifier>ISSN: 0167-7799</identifier><identifier>EISSN: 1879-3096</identifier><identifier>DOI: 10.1016/j.tibtech.2010.08.004</identifier><identifier>PMID: 20832882</identifier><identifier>CODEN: TRBIDM</identifier><language>eng</language><publisher>Cambridge, MA: Elsevier Ltd</publisher><subject>Amides ; Amides - metabolism ; Amino acids ; Ammonia ; Biocatalysts ; Bioconversion ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; Biotechnology - methods ; Biotransformation ; E coli ; Enzymes ; Enzymes - metabolism ; Fundamental and applied biological sciences. Psychology ; Immobilization ; Internal Medicine ; Matrices ; Methods. Procedures. 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Membrane immobilization is specifically highlighted as a route to maximize process performance.</description><subject>Amides</subject><subject>Amides - metabolism</subject><subject>Amino acids</subject><subject>Ammonia</subject><subject>Biocatalysts</subject><subject>Bioconversion</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Biotechnology - methods</subject><subject>Biotransformation</subject><subject>E coli</subject><subject>Enzymes</subject><subject>Enzymes - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immobilization</subject><subject>Internal Medicine</subject><subject>Matrices</subject><subject>Methods. Procedures. 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| subjects | Amides Amides - metabolism Amino acids Ammonia Biocatalysts Bioconversion Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotechnology - methods Biotransformation E coli Enzymes Enzymes - metabolism Fundamental and applied biological sciences. Psychology Immobilization Internal Medicine Matrices Methods. Procedures. Technologies Nitriles Nitriles - metabolism Reuse Strategy |
| title | Developments in nitrile and amide biotransformation processes |
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