A directed alteration of ribonuclease specificity. Hydrolysis of polyribonucleotides containing modified cytosine bases

The action of ribonucleases on poly and oligoribonucleotides containing cytosine bases modified by methoxyamine and bisulphite was examined. Resistance of phosphodiester bonds in (Cp)nXp (where n greater than or equal to 1 and X stands for A, G or U) to T2 RNase hydrolysis was observed if substrates...

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Veröffentlicht in:	Molecular biology reports 1975-10, Vol.2 (3), p.233-239
Hauptverfasser:	Mazo, A M, Schienker, V S, Kisselev, L L
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytosine - analogs & derivatives Escherichia coli - enzymology Oligonucleotides Phosphoric Monoester Hydrolases Polynucleotides Ribonucleases - metabolism Structure-Activity Relationship Sulfites
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