Characterization of atrioventricular nodal response to electrical left vagal stimulation
The dynamic effect of left vagal stimulation on atrioventricular conduction was studied in six isofluorane-anesthetized dogs ranging in weight from 22 to 29 kg. The cervical vagus nerve trunks were left intact and no beta-adrenergic blockade was produced so that any influences of the sympathetic ner...
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| Veröffentlicht in: | Annals of biomedical engineering 1999-11, Vol.27 (6), p.758-762 |
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| creator | WANINGER, M. S BOURLAND, J. D GEDDES, L. A SCHOENLEIN, W. E |
| description | The dynamic effect of left vagal stimulation on atrioventricular conduction was studied in six isofluorane-anesthetized dogs ranging in weight from 22 to 29 kg. The cervical vagus nerve trunks were left intact and no beta-adrenergic blockade was produced so that any influences of the sympathetic nervous system and autonomic reflex activity could be observed. Atrial pacing was used to control the heart rate while single, short trains of left vagal stimulation were delivered and timed to occur at different instances during the cardiac cycle. The magnitude of the A-V delay depended on the instant of delivery of the train of vagal stimuli during the cardiac cycle. Vagal effect curves were constructed and fit to a mathematical equation which describes the pharmacokinetic behavior of a bolus injection of a drug whose onset time is of the same order as its half-life. The three parameters of this equation have physiologic significance and are related to nerve propagation time and synaptic delay, acetylcholine concentration rise, and the acetylcholineesterase mechanism. The maximum A-V delay occurred when the short train of left vagal stimuli was applied 200-300 ms after the atrial pacing stimulus and the total effect was virtually over by 800-1,000 ms. |
| doi_str_mv | 10.1114/1.229 |
| format | Article |
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S ; BOURLAND, J. D ; GEDDES, L. A ; SCHOENLEIN, W. E</creator><creatorcontrib>WANINGER, M. S ; BOURLAND, J. D ; GEDDES, L. A ; SCHOENLEIN, W. E</creatorcontrib><description>The dynamic effect of left vagal stimulation on atrioventricular conduction was studied in six isofluorane-anesthetized dogs ranging in weight from 22 to 29 kg. The cervical vagus nerve trunks were left intact and no beta-adrenergic blockade was produced so that any influences of the sympathetic nervous system and autonomic reflex activity could be observed. Atrial pacing was used to control the heart rate while single, short trains of left vagal stimulation were delivered and timed to occur at different instances during the cardiac cycle. The magnitude of the A-V delay depended on the instant of delivery of the train of vagal stimuli during the cardiac cycle. Vagal effect curves were constructed and fit to a mathematical equation which describes the pharmacokinetic behavior of a bolus injection of a drug whose onset time is of the same order as its half-life. The three parameters of this equation have physiologic significance and are related to nerve propagation time and synaptic delay, acetylcholine concentration rise, and the acetylcholineesterase mechanism. The maximum A-V delay occurred when the short train of left vagal stimuli was applied 200-300 ms after the atrial pacing stimulus and the total effect was virtually over by 800-1,000 ms.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1114/1.229</identifier><identifier>PMID: 10625148</identifier><identifier>CODEN: ABMECF</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Acetylcholine - physiology ; Acetylcholinesterase - physiology ; Animals ; Atrioventricular Node - innervation ; Atrioventricular Node - physiology ; Biological and medical sciences ; Cardiac Pacing, Artificial ; Cardiovascular system ; Dogs ; Electric Stimulation ; Heart ; Heart rate ; Investigative techniques, diagnostic techniques (general aspects) ; Least-Squares Analysis ; Medical sciences ; Myocardial Contraction - physiology ; Nervous system ; Neural Conduction - physiology ; Nonlinear Dynamics ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Pharmacokinetics ; Regression Analysis ; Reproducibility of Results ; Signal Processing, Computer-Assisted ; Synapses - physiology ; Time Factors ; Vagus Nerve - physiology</subject><ispartof>Annals of biomedical engineering, 1999-11, Vol.27 (6), p.758-762</ispartof><rights>2000 INIST-CNRS</rights><rights>Biomedical Engineering Society 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-9ff7db5ee0e10157634958b3f63f948246f47b74f982913fa1006cf5b05b64dd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1219683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10625148$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANINGER, M. S</creatorcontrib><creatorcontrib>BOURLAND, J. D</creatorcontrib><creatorcontrib>GEDDES, L. A</creatorcontrib><creatorcontrib>SCHOENLEIN, W. E</creatorcontrib><title>Characterization of atrioventricular nodal response to electrical left vagal stimulation</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><description>The dynamic effect of left vagal stimulation on atrioventricular conduction was studied in six isofluorane-anesthetized dogs ranging in weight from 22 to 29 kg. The cervical vagus nerve trunks were left intact and no beta-adrenergic blockade was produced so that any influences of the sympathetic nervous system and autonomic reflex activity could be observed. Atrial pacing was used to control the heart rate while single, short trains of left vagal stimulation were delivered and timed to occur at different instances during the cardiac cycle. The magnitude of the A-V delay depended on the instant of delivery of the train of vagal stimuli during the cardiac cycle. Vagal effect curves were constructed and fit to a mathematical equation which describes the pharmacokinetic behavior of a bolus injection of a drug whose onset time is of the same order as its half-life. The three parameters of this equation have physiologic significance and are related to nerve propagation time and synaptic delay, acetylcholine concentration rise, and the acetylcholineesterase mechanism. The maximum A-V delay occurred when the short train of left vagal stimuli was applied 200-300 ms after the atrial pacing stimulus and the total effect was virtually over by 800-1,000 ms.</description><subject>Acetylcholine - physiology</subject><subject>Acetylcholinesterase - physiology</subject><subject>Animals</subject><subject>Atrioventricular Node - innervation</subject><subject>Atrioventricular Node - physiology</subject><subject>Biological and medical sciences</subject><subject>Cardiac Pacing, Artificial</subject><subject>Cardiovascular system</subject><subject>Dogs</subject><subject>Electric Stimulation</subject><subject>Heart</subject><subject>Heart rate</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Least-Squares Analysis</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - physiology</subject><subject>Nervous system</subject><subject>Neural Conduction - physiology</subject><subject>Nonlinear Dynamics</subject><subject>Pathology. 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Miscellaneous investigative techniques</subject><subject>Pharmacokinetics</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Synapses - physiology</subject><subject>Time Factors</subject><subject>Vagus Nerve - physiology</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90VtLwzAUB_Agis65ryBFvDx15jSXNo8yvMHAFwXfSpqeaEfXzKQd6Kc3YwPFB59OSH45nORPyAToFAD4NUyzTO2REYicpUoWcp-MKFU0lUryI3IcwoJSgIKJQ3IEVGYCeDEir7N37bXp0Tdfum9clzib6N43bo1dLGZotU86V-s28RhWrguY9C7BFs3mOG63aPtkrd_iMvTNMl7Y9DkhB1a3ASe7OiYvd7fPs4d0_nT_OLuZp4ZJ6FNlbV5XApEi0Di7ZFyJomJWMqt4kXFpeV7l3KoiU8CsBkqlsaKiopK8rtmYXG37rrz7GDD05bIJBttWd-iGUBYMIM-B8igv_5VSMUVzpiI8-wMXbvBdfEWZCxlHVFkW0cUWGe9C8GjLlW-W2n-WQMtNIiWUMZHoTnfNhmqJ9S-1jSCC8x3QIX6n9bozTfhxGcQ0GfsGVPCRdA</recordid><startdate>19991101</startdate><enddate>19991101</enddate><creator>WANINGER, M. 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S ; BOURLAND, J. D ; GEDDES, L. A ; SCHOENLEIN, W. 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S</au><au>BOURLAND, J. D</au><au>GEDDES, L. A</au><au>SCHOENLEIN, W. E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of atrioventricular nodal response to electrical left vagal stimulation</atitle><jtitle>Annals of biomedical engineering</jtitle><addtitle>Ann Biomed Eng</addtitle><date>1999-11-01</date><risdate>1999</risdate><volume>27</volume><issue>6</issue><spage>758</spage><epage>762</epage><pages>758-762</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><coden>ABMECF</coden><abstract>The dynamic effect of left vagal stimulation on atrioventricular conduction was studied in six isofluorane-anesthetized dogs ranging in weight from 22 to 29 kg. The cervical vagus nerve trunks were left intact and no beta-adrenergic blockade was produced so that any influences of the sympathetic nervous system and autonomic reflex activity could be observed. Atrial pacing was used to control the heart rate while single, short trains of left vagal stimulation were delivered and timed to occur at different instances during the cardiac cycle. The magnitude of the A-V delay depended on the instant of delivery of the train of vagal stimuli during the cardiac cycle. Vagal effect curves were constructed and fit to a mathematical equation which describes the pharmacokinetic behavior of a bolus injection of a drug whose onset time is of the same order as its half-life. The three parameters of this equation have physiologic significance and are related to nerve propagation time and synaptic delay, acetylcholine concentration rise, and the acetylcholineesterase mechanism. The maximum A-V delay occurred when the short train of left vagal stimuli was applied 200-300 ms after the atrial pacing stimulus and the total effect was virtually over by 800-1,000 ms.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>10625148</pmid><doi>10.1114/1.229</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of biomedical engineering, 1999-11, Vol.27 (6), p.758-762 |
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| subjects | Acetylcholine - physiology Acetylcholinesterase - physiology Animals Atrioventricular Node - innervation Atrioventricular Node - physiology Biological and medical sciences Cardiac Pacing, Artificial Cardiovascular system Dogs Electric Stimulation Heart Heart rate Investigative techniques, diagnostic techniques (general aspects) Least-Squares Analysis Medical sciences Myocardial Contraction - physiology Nervous system Neural Conduction - physiology Nonlinear Dynamics Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Pharmacokinetics Regression Analysis Reproducibility of Results Signal Processing, Computer-Assisted Synapses - physiology Time Factors Vagus Nerve - physiology |
| title | Characterization of atrioventricular nodal response to electrical left vagal stimulation |
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