Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation
Rates of coronary restenosis after stent implantation vary with stent design. Recent evidence suggests that alterations in wall shear stress associated with different stent types and changes in local vessel geometry after implantation may account for this disparity. We tested the hypothesis that wal...
Gespeichert in:
| Veröffentlicht in: | Annals of biomedical engineering 2003-09, Vol.31 (8), p.972-980 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 980 |
|---|---|
| container_issue | 8 |
| container_start_page | 972 |
| container_title | Annals of biomedical engineering |
| container_volume | 31 |
| creator | LaDisa, Jr, John F Guler, Ismail Olson, Lars E Hettrick, Douglas A Kersten, Judy R Warltier, David C Pagel, Paul S |
| description | Rates of coronary restenosis after stent implantation vary with stent design. Recent evidence suggests that alterations in wall shear stress associated with different stent types and changes in local vessel geometry after implantation may account for this disparity. We tested the hypothesis that wall shear stress is altered in a three-dimensional computational fluid dynamics (CFD) model after coronary implantation of a 16 mm slotted-tube stent during simulations of resting blood flow and maximal vasodilation. Canine left anterior descending coronary artery blood flow velocity and interior diameter were used to construct CFD models and evaluate wall shear stress proximal and distal to and within the stented region. Channeling of adjacent blood layers due to stent geometry had a profound affect on wall shear stress. Stagnation zones were localized around stent struts. Minimum wall shear stress decreased by 77% in stented compared to unstented vessels. Regions of low wall shear stress were extended at the stent outlet and localized to regions where adjacent axial strut spacing was minimized and the circumferential distance between struts was greatest within the stent. The present results depict alterations in wall shear stress caused by a slotted-tube stent and support the hypothesis that stent geometry may be a risk factor for restenosis by affecting local wall shear stress distributions. |
| doi_str_mv | 10.1114/1.1588654 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_831176042</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2155543781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c404t-5e5a220115041bb1ef52b6d094ee765af29b72172470e0c65b7f0e6d22b0db5a3</originalsourceid><addsrcrecordid>eNqF0klr3DAUAGARWppp0kP-QBE5dDk41dNqHUvoBoFe0rORrOdEQbYnkk2Yc_94lc5AoIf0JCS-t0h6hJwBuwAA-QkuQLWtVvKIbEAZ0Vjd6hdkw5hljbZaHpPXpdwxBtAK9YocA7fQWuAb8vv6NiM2IY44lThPLtF-Hrfr4pb9bkhrDDTsJjfGvtBxDpjidEPngbq0YP7rCo1Tjcs1Iu_og0uJllt0mZYlYyl0m-ew9hio39UjnBYax21y077KKXk5uFTwzWE9Ib--frm-_N5c_fz24_LzVdNLJpdGoXKc1zsoJsF7wEFxrwOzEtFo5QZuveFguDQMWa-VNwNDHTj3LHjlxAl5v89b27lfsSzdGEuPqTaC81q6VgAYzSSv8t2z0ggtBbTyvxCMsowLW-GH56E2ILRSsq30_B96N6-5_kWtq7SR3Fhd0cc96vNcSsah2-Y41tfvgHWPQ9FBdxiKat8eEq5-xPAkD1Mg_gAPVbJF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>756742796</pqid></control><display><type>article</type><title>Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation</title><source>MEDLINE</source><source>Springer Online Journals</source><creator>LaDisa, Jr, John F ; Guler, Ismail ; Olson, Lars E ; Hettrick, Douglas A ; Kersten, Judy R ; Warltier, David C ; Pagel, Paul S</creator><creatorcontrib>LaDisa, Jr, John F ; Guler, Ismail ; Olson, Lars E ; Hettrick, Douglas A ; Kersten, Judy R ; Warltier, David C ; Pagel, Paul S</creatorcontrib><description>Rates of coronary restenosis after stent implantation vary with stent design. Recent evidence suggests that alterations in wall shear stress associated with different stent types and changes in local vessel geometry after implantation may account for this disparity. We tested the hypothesis that wall shear stress is altered in a three-dimensional computational fluid dynamics (CFD) model after coronary implantation of a 16 mm slotted-tube stent during simulations of resting blood flow and maximal vasodilation. Canine left anterior descending coronary artery blood flow velocity and interior diameter were used to construct CFD models and evaluate wall shear stress proximal and distal to and within the stented region. Channeling of adjacent blood layers due to stent geometry had a profound affect on wall shear stress. Stagnation zones were localized around stent struts. Minimum wall shear stress decreased by 77% in stented compared to unstented vessels. Regions of low wall shear stress were extended at the stent outlet and localized to regions where adjacent axial strut spacing was minimized and the circumferential distance between struts was greatest within the stent. The present results depict alterations in wall shear stress caused by a slotted-tube stent and support the hypothesis that stent geometry may be a risk factor for restenosis by affecting local wall shear stress distributions.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1114/1.1588654</identifier><identifier>PMID: 12918912</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adenosine - pharmacology ; Alterations ; Animals ; Arteries - drug effects ; Arteries - physiopathology ; Arteries - surgery ; Biomedical engineering ; Blood flow ; Blood Flow Velocity ; Blood Vessel Prosthesis ; Computational fluid dynamics ; Computer Simulation ; Coronary Vessels - drug effects ; Coronary Vessels - physiopathology ; Coronary Vessels - surgery ; Dogs ; Flow velocity ; Fluid dynamics ; Geometry ; Hemorheology - methods ; Hydrodynamics ; Implantation ; Mathematical models ; Models, Cardiovascular ; Pulmonary arteries ; Risk factors ; Shear Strength ; Shear stress ; Stents ; Struts ; Surgical implants ; Vasodilator Agents - pharmacology ; Wall shear stresses</subject><ispartof>Annals of biomedical engineering, 2003-09, Vol.31 (8), p.972-980</ispartof><rights>Biomedical Engineering Society 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-5e5a220115041bb1ef52b6d094ee765af29b72172470e0c65b7f0e6d22b0db5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12918912$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LaDisa, Jr, John F</creatorcontrib><creatorcontrib>Guler, Ismail</creatorcontrib><creatorcontrib>Olson, Lars E</creatorcontrib><creatorcontrib>Hettrick, Douglas A</creatorcontrib><creatorcontrib>Kersten, Judy R</creatorcontrib><creatorcontrib>Warltier, David C</creatorcontrib><creatorcontrib>Pagel, Paul S</creatorcontrib><title>Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><description>Rates of coronary restenosis after stent implantation vary with stent design. Recent evidence suggests that alterations in wall shear stress associated with different stent types and changes in local vessel geometry after implantation may account for this disparity. We tested the hypothesis that wall shear stress is altered in a three-dimensional computational fluid dynamics (CFD) model after coronary implantation of a 16 mm slotted-tube stent during simulations of resting blood flow and maximal vasodilation. Canine left anterior descending coronary artery blood flow velocity and interior diameter were used to construct CFD models and evaluate wall shear stress proximal and distal to and within the stented region. Channeling of adjacent blood layers due to stent geometry had a profound affect on wall shear stress. Stagnation zones were localized around stent struts. Minimum wall shear stress decreased by 77% in stented compared to unstented vessels. Regions of low wall shear stress were extended at the stent outlet and localized to regions where adjacent axial strut spacing was minimized and the circumferential distance between struts was greatest within the stent. The present results depict alterations in wall shear stress caused by a slotted-tube stent and support the hypothesis that stent geometry may be a risk factor for restenosis by affecting local wall shear stress distributions.</description><subject>Adenosine - pharmacology</subject><subject>Alterations</subject><subject>Animals</subject><subject>Arteries - drug effects</subject><subject>Arteries - physiopathology</subject><subject>Arteries - surgery</subject><subject>Biomedical engineering</subject><subject>Blood flow</subject><subject>Blood Flow Velocity</subject><subject>Blood Vessel Prosthesis</subject><subject>Computational fluid dynamics</subject><subject>Computer Simulation</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - physiopathology</subject><subject>Coronary Vessels - surgery</subject><subject>Dogs</subject><subject>Flow velocity</subject><subject>Fluid dynamics</subject><subject>Geometry</subject><subject>Hemorheology - methods</subject><subject>Hydrodynamics</subject><subject>Implantation</subject><subject>Mathematical models</subject><subject>Models, Cardiovascular</subject><subject>Pulmonary arteries</subject><subject>Risk factors</subject><subject>Shear Strength</subject><subject>Shear stress</subject><subject>Stents</subject><subject>Struts</subject><subject>Surgical implants</subject><subject>Vasodilator Agents - pharmacology</subject><subject>Wall shear stresses</subject><issn>0090-6964</issn><issn>1573-9686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0klr3DAUAGARWppp0kP-QBE5dDk41dNqHUvoBoFe0rORrOdEQbYnkk2Yc_94lc5AoIf0JCS-t0h6hJwBuwAA-QkuQLWtVvKIbEAZ0Vjd6hdkw5hljbZaHpPXpdwxBtAK9YocA7fQWuAb8vv6NiM2IY44lThPLtF-Hrfr4pb9bkhrDDTsJjfGvtBxDpjidEPngbq0YP7rCo1Tjcs1Iu_og0uJllt0mZYlYyl0m-ew9hio39UjnBYax21y077KKXk5uFTwzWE9Ib--frm-_N5c_fz24_LzVdNLJpdGoXKc1zsoJsF7wEFxrwOzEtFo5QZuveFguDQMWa-VNwNDHTj3LHjlxAl5v89b27lfsSzdGEuPqTaC81q6VgAYzSSv8t2z0ggtBbTyvxCMsowLW-GH56E2ILRSsq30_B96N6-5_kWtq7SR3Fhd0cc96vNcSsah2-Y41tfvgHWPQ9FBdxiKat8eEq5-xPAkD1Mg_gAPVbJF</recordid><startdate>20030901</startdate><enddate>20030901</enddate><creator>LaDisa, Jr, John F</creator><creator>Guler, Ismail</creator><creator>Olson, Lars E</creator><creator>Hettrick, Douglas A</creator><creator>Kersten, Judy R</creator><creator>Warltier, David C</creator><creator>Pagel, Paul S</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>M7S</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>7X8</scope></search><sort><creationdate>20030901</creationdate><title>Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation</title><author>LaDisa, Jr, John F ; Guler, Ismail ; Olson, Lars E ; Hettrick, Douglas A ; Kersten, Judy R ; Warltier, David C ; Pagel, Paul S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-5e5a220115041bb1ef52b6d094ee765af29b72172470e0c65b7f0e6d22b0db5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenosine - pharmacology</topic><topic>Alterations</topic><topic>Animals</topic><topic>Arteries - drug effects</topic><topic>Arteries - physiopathology</topic><topic>Arteries - surgery</topic><topic>Biomedical engineering</topic><topic>Blood flow</topic><topic>Blood Flow Velocity</topic><topic>Blood Vessel Prosthesis</topic><topic>Computational fluid dynamics</topic><topic>Computer Simulation</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - physiopathology</topic><topic>Coronary Vessels - surgery</topic><topic>Dogs</topic><topic>Flow velocity</topic><topic>Fluid dynamics</topic><topic>Geometry</topic><topic>Hemorheology - methods</topic><topic>Hydrodynamics</topic><topic>Implantation</topic><topic>Mathematical models</topic><topic>Models, Cardiovascular</topic><topic>Pulmonary arteries</topic><topic>Risk factors</topic><topic>Shear Strength</topic><topic>Shear stress</topic><topic>Stents</topic><topic>Struts</topic><topic>Surgical implants</topic><topic>Vasodilator Agents - pharmacology</topic><topic>Wall shear stresses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LaDisa, Jr, John F</creatorcontrib><creatorcontrib>Guler, Ismail</creatorcontrib><creatorcontrib>Olson, Lars E</creatorcontrib><creatorcontrib>Hettrick, Douglas A</creatorcontrib><creatorcontrib>Kersten, Judy R</creatorcontrib><creatorcontrib>Warltier, David C</creatorcontrib><creatorcontrib>Pagel, Paul S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biological Sciences</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of biomedical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LaDisa, Jr, John F</au><au>Guler, Ismail</au><au>Olson, Lars E</au><au>Hettrick, Douglas A</au><au>Kersten, Judy R</au><au>Warltier, David C</au><au>Pagel, Paul S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation</atitle><jtitle>Annals of biomedical engineering</jtitle><addtitle>Ann Biomed Eng</addtitle><date>2003-09-01</date><risdate>2003</risdate><volume>31</volume><issue>8</issue><spage>972</spage><epage>980</epage><pages>972-980</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><abstract>Rates of coronary restenosis after stent implantation vary with stent design. Recent evidence suggests that alterations in wall shear stress associated with different stent types and changes in local vessel geometry after implantation may account for this disparity. We tested the hypothesis that wall shear stress is altered in a three-dimensional computational fluid dynamics (CFD) model after coronary implantation of a 16 mm slotted-tube stent during simulations of resting blood flow and maximal vasodilation. Canine left anterior descending coronary artery blood flow velocity and interior diameter were used to construct CFD models and evaluate wall shear stress proximal and distal to and within the stented region. Channeling of adjacent blood layers due to stent geometry had a profound affect on wall shear stress. Stagnation zones were localized around stent struts. Minimum wall shear stress decreased by 77% in stented compared to unstented vessels. Regions of low wall shear stress were extended at the stent outlet and localized to regions where adjacent axial strut spacing was minimized and the circumferential distance between struts was greatest within the stent. The present results depict alterations in wall shear stress caused by a slotted-tube stent and support the hypothesis that stent geometry may be a risk factor for restenosis by affecting local wall shear stress distributions.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>12918912</pmid><doi>10.1114/1.1588654</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-6964 |
| ispartof | Annals of biomedical engineering, 2003-09, Vol.31 (8), p.972-980 |
| issn | 0090-6964 1573-9686 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_831176042 |
| source | MEDLINE; Springer Online Journals |
| subjects | Adenosine - pharmacology Alterations Animals Arteries - drug effects Arteries - physiopathology Arteries - surgery Biomedical engineering Blood flow Blood Flow Velocity Blood Vessel Prosthesis Computational fluid dynamics Computer Simulation Coronary Vessels - drug effects Coronary Vessels - physiopathology Coronary Vessels - surgery Dogs Flow velocity Fluid dynamics Geometry Hemorheology - methods Hydrodynamics Implantation Mathematical models Models, Cardiovascular Pulmonary arteries Risk factors Shear Strength Shear stress Stents Struts Surgical implants Vasodilator Agents - pharmacology Wall shear stresses |
| title | Three-dimensional computational fluid dynamics modeling of alterations in coronary wall shear stress produced by stent implantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T16%3A40%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Three-dimensional%20computational%20fluid%20dynamics%20modeling%20of%20alterations%20in%20coronary%20wall%20shear%20stress%20produced%20by%20stent%20implantation&rft.jtitle=Annals%20of%20biomedical%20engineering&rft.au=LaDisa,%20Jr,%20John%20F&rft.date=2003-09-01&rft.volume=31&rft.issue=8&rft.spage=972&rft.epage=980&rft.pages=972-980&rft.issn=0090-6964&rft.eissn=1573-9686&rft_id=info:doi/10.1114/1.1588654&rft_dat=%3Cproquest_cross%3E2155543781%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=756742796&rft_id=info:pmid/12918912&rfr_iscdi=true |