Nonlinear analysis of renal autoregulation in rats using principal dynamic modes
This article presents results of the use of a novel methodology employing principal dynamic modes (PDM) for modeling the nonlinear dynamics of renal autoregulation in rats. The analyzed experimental data are broadband (0-0.5 Hz) blood pressure-flow data generated by pseudorandom forcing and collecte...
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| Veröffentlicht in: | Annals of biomedical engineering 1999, Vol.27 (1), p.23-31 |
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| creator | MARMARELIS, V. Z CHON, K. H HOLSTEIN-RATHLOU, N. H MARSH, D. J |
| description | This article presents results of the use of a novel methodology employing principal dynamic modes (PDM) for modeling the nonlinear dynamics of renal autoregulation in rats. The analyzed experimental data are broadband (0-0.5 Hz) blood pressure-flow data generated by pseudorandom forcing and collected in normotensive and hypertensive rats for two levels of pressure forcing (as measured by the standard deviation of the pressure fluctuation). The PDMs are computed from first-order and second-order kernel estimates obtained from the data via the Laguerre expansion technique. The results demonstrate that two PDMs suffice for obtaining a satisfactory nonlinear dynamic model of renal autoregulation under these conditions, for both normotensive and hypertensive rats. Furthermore, the two PDMs appear to correspond to the two main autoregulatory mechanisms: the first to the myogenic and the second to the tubuloglomerular feedback (TGF) mechanism. This allows the study of the separate contributions of the two mechanisms to the autoregulatory response dynamics, as well as the effects of the level of pressure forcing and hypertension on the two distinct autoregulatory mechanisms. It is shown that the myogenic mechanism has a larger contribution and is affected only slightly, while the TGF mechanism is affected considerably by increasing pressure forcing or hypertension (the emergence of a second resonant peak and the decreased relative contribution to the response flow signal). |
| doi_str_mv | 10.1114/1.222 |
| format | Article |
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Z ; CHON, K. H ; HOLSTEIN-RATHLOU, N. H ; MARSH, D. J</creator><creatorcontrib>MARMARELIS, V. Z ; CHON, K. H ; HOLSTEIN-RATHLOU, N. H ; MARSH, D. J</creatorcontrib><description>This article presents results of the use of a novel methodology employing principal dynamic modes (PDM) for modeling the nonlinear dynamics of renal autoregulation in rats. The analyzed experimental data are broadband (0-0.5 Hz) blood pressure-flow data generated by pseudorandom forcing and collected in normotensive and hypertensive rats for two levels of pressure forcing (as measured by the standard deviation of the pressure fluctuation). The PDMs are computed from first-order and second-order kernel estimates obtained from the data via the Laguerre expansion technique. The results demonstrate that two PDMs suffice for obtaining a satisfactory nonlinear dynamic model of renal autoregulation under these conditions, for both normotensive and hypertensive rats. Furthermore, the two PDMs appear to correspond to the two main autoregulatory mechanisms: the first to the myogenic and the second to the tubuloglomerular feedback (TGF) mechanism. This allows the study of the separate contributions of the two mechanisms to the autoregulatory response dynamics, as well as the effects of the level of pressure forcing and hypertension on the two distinct autoregulatory mechanisms. It is shown that the myogenic mechanism has a larger contribution and is affected only slightly, while the TGF mechanism is affected considerably by increasing pressure forcing or hypertension (the emergence of a second resonant peak and the decreased relative contribution to the response flow signal).</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1114/1.222</identifier><identifier>PMID: 9916757</identifier><identifier>CODEN: ABMECF</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Biological and medical sciences ; Biomedical engineering ; Blood pressure ; Broadband ; Dynamic tests ; Emergence ; Endocrine kidney. Renin-angiotensin-aldosterone system ; Fundamental and applied biological sciences. Psychology ; Homeostasis - physiology ; Hypertension ; Kidney - physiology ; Male ; Models, Biological ; Nonlinear dynamics ; Product data management ; Rats ; Rats, Sprague-Dawley ; Reproduction ; Rodents ; Standard deviation ; Vertebrates: endocrinology</subject><ispartof>Annals of biomedical engineering, 1999, Vol.27 (1), p.23-31</ispartof><rights>1999 INIST-CNRS</rights><rights>Biomedical Engineering Society 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-6c709f654766804387fbb1e9f2283cd10166bcec03be2dd2cb540aaf3d03b18b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1643199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9916757$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARMARELIS, V. Z</creatorcontrib><creatorcontrib>CHON, K. H</creatorcontrib><creatorcontrib>HOLSTEIN-RATHLOU, N. H</creatorcontrib><creatorcontrib>MARSH, D. J</creatorcontrib><title>Nonlinear analysis of renal autoregulation in rats using principal dynamic modes</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><description>This article presents results of the use of a novel methodology employing principal dynamic modes (PDM) for modeling the nonlinear dynamics of renal autoregulation in rats. The analyzed experimental data are broadband (0-0.5 Hz) blood pressure-flow data generated by pseudorandom forcing and collected in normotensive and hypertensive rats for two levels of pressure forcing (as measured by the standard deviation of the pressure fluctuation). The PDMs are computed from first-order and second-order kernel estimates obtained from the data via the Laguerre expansion technique. The results demonstrate that two PDMs suffice for obtaining a satisfactory nonlinear dynamic model of renal autoregulation under these conditions, for both normotensive and hypertensive rats. Furthermore, the two PDMs appear to correspond to the two main autoregulatory mechanisms: the first to the myogenic and the second to the tubuloglomerular feedback (TGF) mechanism. This allows the study of the separate contributions of the two mechanisms to the autoregulatory response dynamics, as well as the effects of the level of pressure forcing and hypertension on the two distinct autoregulatory mechanisms. It is shown that the myogenic mechanism has a larger contribution and is affected only slightly, while the TGF mechanism is affected considerably by increasing pressure forcing or hypertension (the emergence of a second resonant peak and the decreased relative contribution to the response flow signal).</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical engineering</subject><subject>Blood pressure</subject><subject>Broadband</subject><subject>Dynamic tests</subject><subject>Emergence</subject><subject>Endocrine kidney. Renin-angiotensin-aldosterone system</subject><subject>Fundamental and applied biological sciences. 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Z</au><au>CHON, K. H</au><au>HOLSTEIN-RATHLOU, N. H</au><au>MARSH, D. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonlinear analysis of renal autoregulation in rats using principal dynamic modes</atitle><jtitle>Annals of biomedical engineering</jtitle><addtitle>Ann Biomed Eng</addtitle><date>1999</date><risdate>1999</risdate><volume>27</volume><issue>1</issue><spage>23</spage><epage>31</epage><pages>23-31</pages><issn>0090-6964</issn><eissn>1573-9686</eissn><coden>ABMECF</coden><abstract>This article presents results of the use of a novel methodology employing principal dynamic modes (PDM) for modeling the nonlinear dynamics of renal autoregulation in rats. The analyzed experimental data are broadband (0-0.5 Hz) blood pressure-flow data generated by pseudorandom forcing and collected in normotensive and hypertensive rats for two levels of pressure forcing (as measured by the standard deviation of the pressure fluctuation). The PDMs are computed from first-order and second-order kernel estimates obtained from the data via the Laguerre expansion technique. The results demonstrate that two PDMs suffice for obtaining a satisfactory nonlinear dynamic model of renal autoregulation under these conditions, for both normotensive and hypertensive rats. Furthermore, the two PDMs appear to correspond to the two main autoregulatory mechanisms: the first to the myogenic and the second to the tubuloglomerular feedback (TGF) mechanism. This allows the study of the separate contributions of the two mechanisms to the autoregulatory response dynamics, as well as the effects of the level of pressure forcing and hypertension on the two distinct autoregulatory mechanisms. It is shown that the myogenic mechanism has a larger contribution and is affected only slightly, while the TGF mechanism is affected considerably by increasing pressure forcing or hypertension (the emergence of a second resonant peak and the decreased relative contribution to the response flow signal).</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>9916757</pmid><doi>10.1114/1.222</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Biomedical engineering Blood pressure Broadband Dynamic tests Emergence Endocrine kidney. Renin-angiotensin-aldosterone system Fundamental and applied biological sciences. Psychology Homeostasis - physiology Hypertension Kidney - physiology Male Models, Biological Nonlinear dynamics Product data management Rats Rats, Sprague-Dawley Reproduction Rodents Standard deviation Vertebrates: endocrinology |
| title | Nonlinear analysis of renal autoregulation in rats using principal dynamic modes |
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