Synthesis and characterisation of poly(2-hydroxyethyl methacrylate) polyelectrolyte complexes
Copolymerisation of charged and neutral monomers is a well-known methodology to introduce charged moieties in a polymeric chain to obtain polyelectrolytes. New polyelectrolyte complexes have been synthesised by radical copolymerisation of neutral methacrylic monomer 2-hydroxyethyl methacrylate (HEMA...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2004-06, Vol.15 (6), p.679-686 |
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| creator | Rosso, F Barbarisi, A Barbarisi, M Giordano, A Ambrosio, L |
| description | Copolymerisation of charged and neutral monomers is a well-known methodology to introduce charged moieties in a polymeric chain to obtain polyelectrolytes. New polyelectrolyte complexes have been synthesised by radical copolymerisation of neutral methacrylic monomer 2-hydroxyethyl methacrylate (HEMA) with cationic 2-methacryloyloxyethyltrimethyl ammonium chloride and anionic 2-acrylamido-2-methylpropane-sulphonic acid monomers in 10:1:1 and 10:1:2 stechiometric ratio. Chemical structure of the synthesised terpolymers was confirmed by FT-IR spectroscopy, moreover, X-ray photoelectron spectroscopy showed the presence of a cationic charge excess on the 10:1:2 terpolymer surface with respect to 10:1:1 terpolymer. Swelling studies for 10:1:2 terpolymers showed a high water content in the swollen state and a "smart behaviour" upon changes in external stimuli such as pH, while, 10:1:1 terpolymer presented the behaviour of a neutral polymer. Mechanical and differential scanning calorimetry analysis confirmed that terpolymer networks were stabilised by ionic co-operative interactions. Infact, the inclusion of oppositely ionic charges in the polymeric network of p(HEMA) represent a way to achieve higher elastic modulus as they stabilise the terpolymer networks. Cytotoxicity and cytocompatibility studies demonstrated that all materials were not toxic, moreover, the presence of a cationic charge excess on 10:1:2 terpolymer surface was able to promote fibroblast adhesion. |
| doi_str_mv | 10.1023/B:JMSM.0000030209.61226.a1 |
| format | Article |
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New polyelectrolyte complexes have been synthesised by radical copolymerisation of neutral methacrylic monomer 2-hydroxyethyl methacrylate (HEMA) with cationic 2-methacryloyloxyethyltrimethyl ammonium chloride and anionic 2-acrylamido-2-methylpropane-sulphonic acid monomers in 10:1:1 and 10:1:2 stechiometric ratio. Chemical structure of the synthesised terpolymers was confirmed by FT-IR spectroscopy, moreover, X-ray photoelectron spectroscopy showed the presence of a cationic charge excess on the 10:1:2 terpolymer surface with respect to 10:1:1 terpolymer. Swelling studies for 10:1:2 terpolymers showed a high water content in the swollen state and a "smart behaviour" upon changes in external stimuli such as pH, while, 10:1:1 terpolymer presented the behaviour of a neutral polymer. Mechanical and differential scanning calorimetry analysis confirmed that terpolymer networks were stabilised by ionic co-operative interactions. Infact, the inclusion of oppositely ionic charges in the polymeric network of p(HEMA) represent a way to achieve higher elastic modulus as they stabilise the terpolymer networks. Cytotoxicity and cytocompatibility studies demonstrated that all materials were not toxic, moreover, the presence of a cationic charge excess on 10:1:2 terpolymer surface was able to promote fibroblast adhesion.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1023/B:JMSM.0000030209.61226.a1</identifier><identifier>PMID: 15346735</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Absorption ; Acrylamides - chemistry ; Alkanesulfonates - chemistry ; Biocompatible Materials - chemistry ; Biomedical materials ; Cell Adhesion ; Cell Division ; Cell Size ; Cell Survival ; Cells, Cultured ; Elasticity ; Electrolytes - chemistry ; Fibroblasts - cytology ; Fibroblasts - physiology ; Humans ; Hydrogen-Ion Concentration ; Materials science ; Methacrylates - chemistry ; Polyhydroxyethyl Methacrylate - chemistry ; Prostheses and Implants ; Spectrum analysis ; Surface Properties ; Tensile Strength ; Water - chemistry</subject><ispartof>Journal of materials science. Materials in medicine, 2004-06, Vol.15 (6), p.679-686</ispartof><rights>Kluwer Academic Publishers 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-dc5d04a064b30707110429785f7f69af7704231b15e74a7654549dd3dfb370863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15346735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rosso, F</creatorcontrib><creatorcontrib>Barbarisi, A</creatorcontrib><creatorcontrib>Barbarisi, M</creatorcontrib><creatorcontrib>Giordano, A</creatorcontrib><creatorcontrib>Ambrosio, L</creatorcontrib><title>Synthesis and characterisation of poly(2-hydroxyethyl methacrylate) polyelectrolyte complexes</title><title>Journal of materials science. Materials in medicine</title><addtitle>J Mater Sci Mater Med</addtitle><description>Copolymerisation of charged and neutral monomers is a well-known methodology to introduce charged moieties in a polymeric chain to obtain polyelectrolytes. New polyelectrolyte complexes have been synthesised by radical copolymerisation of neutral methacrylic monomer 2-hydroxyethyl methacrylate (HEMA) with cationic 2-methacryloyloxyethyltrimethyl ammonium chloride and anionic 2-acrylamido-2-methylpropane-sulphonic acid monomers in 10:1:1 and 10:1:2 stechiometric ratio. Chemical structure of the synthesised terpolymers was confirmed by FT-IR spectroscopy, moreover, X-ray photoelectron spectroscopy showed the presence of a cationic charge excess on the 10:1:2 terpolymer surface with respect to 10:1:1 terpolymer. Swelling studies for 10:1:2 terpolymers showed a high water content in the swollen state and a "smart behaviour" upon changes in external stimuli such as pH, while, 10:1:1 terpolymer presented the behaviour of a neutral polymer. Mechanical and differential scanning calorimetry analysis confirmed that terpolymer networks were stabilised by ionic co-operative interactions. Infact, the inclusion of oppositely ionic charges in the polymeric network of p(HEMA) represent a way to achieve higher elastic modulus as they stabilise the terpolymer networks. Cytotoxicity and cytocompatibility studies demonstrated that all materials were not toxic, moreover, the presence of a cationic charge excess on 10:1:2 terpolymer surface was able to promote fibroblast adhesion.</description><subject>Absorption</subject><subject>Acrylamides - chemistry</subject><subject>Alkanesulfonates - chemistry</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biomedical materials</subject><subject>Cell Adhesion</subject><subject>Cell Division</subject><subject>Cell Size</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Elasticity</subject><subject>Electrolytes - chemistry</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - physiology</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Materials science</subject><subject>Methacrylates - chemistry</subject><subject>Polyhydroxyethyl Methacrylate - chemistry</subject><subject>Prostheses and Implants</subject><subject>Spectrum analysis</subject><subject>Surface Properties</subject><subject>Tensile Strength</subject><subject>Water - 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Materials in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rosso, F</au><au>Barbarisi, A</au><au>Barbarisi, M</au><au>Giordano, A</au><au>Ambrosio, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterisation of poly(2-hydroxyethyl methacrylate) polyelectrolyte complexes</atitle><jtitle>Journal of materials science. Materials in medicine</jtitle><addtitle>J Mater Sci Mater Med</addtitle><date>2004-06</date><risdate>2004</risdate><volume>15</volume><issue>6</issue><spage>679</spage><epage>686</epage><pages>679-686</pages><issn>0957-4530</issn><eissn>1573-4838</eissn><abstract>Copolymerisation of charged and neutral monomers is a well-known methodology to introduce charged moieties in a polymeric chain to obtain polyelectrolytes. New polyelectrolyte complexes have been synthesised by radical copolymerisation of neutral methacrylic monomer 2-hydroxyethyl methacrylate (HEMA) with cationic 2-methacryloyloxyethyltrimethyl ammonium chloride and anionic 2-acrylamido-2-methylpropane-sulphonic acid monomers in 10:1:1 and 10:1:2 stechiometric ratio. Chemical structure of the synthesised terpolymers was confirmed by FT-IR spectroscopy, moreover, X-ray photoelectron spectroscopy showed the presence of a cationic charge excess on the 10:1:2 terpolymer surface with respect to 10:1:1 terpolymer. Swelling studies for 10:1:2 terpolymers showed a high water content in the swollen state and a "smart behaviour" upon changes in external stimuli such as pH, while, 10:1:1 terpolymer presented the behaviour of a neutral polymer. Mechanical and differential scanning calorimetry analysis confirmed that terpolymer networks were stabilised by ionic co-operative interactions. Infact, the inclusion of oppositely ionic charges in the polymeric network of p(HEMA) represent a way to achieve higher elastic modulus as they stabilise the terpolymer networks. Cytotoxicity and cytocompatibility studies demonstrated that all materials were not toxic, moreover, the presence of a cationic charge excess on 10:1:2 terpolymer surface was able to promote fibroblast adhesion.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>15346735</pmid><doi>10.1023/B:JMSM.0000030209.61226.a1</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of materials science. Materials in medicine, 2004-06, Vol.15 (6), p.679-686 |
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| subjects | Absorption Acrylamides - chemistry Alkanesulfonates - chemistry Biocompatible Materials - chemistry Biomedical materials Cell Adhesion Cell Division Cell Size Cell Survival Cells, Cultured Elasticity Electrolytes - chemistry Fibroblasts - cytology Fibroblasts - physiology Humans Hydrogen-Ion Concentration Materials science Methacrylates - chemistry Polyhydroxyethyl Methacrylate - chemistry Prostheses and Implants Spectrum analysis Surface Properties Tensile Strength Water - chemistry |
| title | Synthesis and characterisation of poly(2-hydroxyethyl methacrylate) polyelectrolyte complexes |
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