Correlation of cartilage stiffness to thickness and level of degeneration using a handheld indentation probe
The in vivo assessment of the quality of cartilage is a critical tool to determine how to clinically treat damaged cartilage. Utilizing nondestructive indentation, a hand-held instrument (ACTAEON Probe) was used to rapidly measure the stiffness of articular cartilage, which can then be correlated to...
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| Veröffentlicht in: | Annals of biomedical engineering 2004-03, Vol.32 (3), p.352-359 |
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| creator | Niederauer, Gabriele G Niederauer, George M Cullen, Jr, Larry C Athanasiou, Kyriacos A Thomas, James B Niederauer, Mark Q |
| description | The in vivo assessment of the quality of cartilage is a critical tool to determine how to clinically treat damaged cartilage. Utilizing nondestructive indentation, a hand-held instrument (ACTAEON Probe) was used to rapidly measure the stiffness of articular cartilage, which can then be correlated to cartilage condition. An integrated series of tests were performed to determine whether the Probe is sensitive enough to detect early degenerative changes in articular cartilage and to examine if it is dependent on the thickness of the cartilage being tested. Results demonstrated that there is no effect of thickness on the Probe measurements for clinically relevant human cartilage samples, that the Probe is sensitive enough to detect different levels of cartilage degeneration, and that Probe data correlate well with traditional creep indentation testing. This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints. |
| doi_str_mv | 10.1023/b:abme.0000017550.02388.c5 |
| format | Article |
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Utilizing nondestructive indentation, a hand-held instrument (ACTAEON Probe) was used to rapidly measure the stiffness of articular cartilage, which can then be correlated to cartilage condition. An integrated series of tests were performed to determine whether the Probe is sensitive enough to detect early degenerative changes in articular cartilage and to examine if it is dependent on the thickness of the cartilage being tested. Results demonstrated that there is no effect of thickness on the Probe measurements for clinically relevant human cartilage samples, that the Probe is sensitive enough to detect different levels of cartilage degeneration, and that Probe data correlate well with traditional creep indentation testing. This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints.</description><identifier>ISSN: 0090-6964</identifier><identifier>EISSN: 1573-9686</identifier><identifier>DOI: 10.1023/b:abme.0000017550.02388.c5</identifier><identifier>PMID: 15095809</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Cadaver ; Cartilage ; Cartilage Diseases - classification ; Cartilage Diseases - diagnosis ; Cartilage Diseases - pathology ; Cartilage Diseases - physiopathology ; Cartilage, Articular - pathology ; Cartilage, Articular - physiopathology ; Diagnosis, Computer-Assisted - methods ; Elasticity ; Equipment Design ; Equipment Failure Analysis ; Goats ; Hardness Tests - instrumentation ; Hardness Tests - methods ; Humans ; In Vitro Techniques ; Knee Joint ; Miniaturization ; Papio ; Physical Examination - instrumentation ; Physical Examination - methods ; Physical Stimulation - instrumentation ; Physical Stimulation - methods ; Rabbits ; Sensitivity and Specificity ; Severity of Illness Index ; Species Specificity ; Statistics as Topic ; Stress, Mechanical</subject><ispartof>Annals of biomedical engineering, 2004-03, Vol.32 (3), p.352-359</ispartof><rights>Biomedical Engineering Society 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-4269b8520294a9bcf6c3e63d0f0017167230ddeaf5a53839b37163e8d063f7b53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15095809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niederauer, Gabriele G</creatorcontrib><creatorcontrib>Niederauer, George M</creatorcontrib><creatorcontrib>Cullen, Jr, Larry C</creatorcontrib><creatorcontrib>Athanasiou, Kyriacos A</creatorcontrib><creatorcontrib>Thomas, James B</creatorcontrib><creatorcontrib>Niederauer, Mark Q</creatorcontrib><title>Correlation of cartilage stiffness to thickness and level of degeneration using a handheld indentation probe</title><title>Annals of biomedical engineering</title><addtitle>Ann Biomed Eng</addtitle><description>The in vivo assessment of the quality of cartilage is a critical tool to determine how to clinically treat damaged cartilage. Utilizing nondestructive indentation, a hand-held instrument (ACTAEON Probe) was used to rapidly measure the stiffness of articular cartilage, which can then be correlated to cartilage condition. An integrated series of tests were performed to determine whether the Probe is sensitive enough to detect early degenerative changes in articular cartilage and to examine if it is dependent on the thickness of the cartilage being tested. Results demonstrated that there is no effect of thickness on the Probe measurements for clinically relevant human cartilage samples, that the Probe is sensitive enough to detect different levels of cartilage degeneration, and that Probe data correlate well with traditional creep indentation testing. This study demonstrates the utility of the Probe for detecting degenerative changes in animal and human joints.</description><subject>Animals</subject><subject>Cadaver</subject><subject>Cartilage</subject><subject>Cartilage Diseases - classification</subject><subject>Cartilage Diseases - diagnosis</subject><subject>Cartilage Diseases - pathology</subject><subject>Cartilage Diseases - physiopathology</subject><subject>Cartilage, Articular - pathology</subject><subject>Cartilage, Articular - physiopathology</subject><subject>Diagnosis, Computer-Assisted - methods</subject><subject>Elasticity</subject><subject>Equipment Design</subject><subject>Equipment Failure Analysis</subject><subject>Goats</subject><subject>Hardness Tests - instrumentation</subject><subject>Hardness Tests - methods</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Knee Joint</subject><subject>Miniaturization</subject><subject>Papio</subject><subject>Physical Examination - 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Utilizing nondestructive indentation, a hand-held instrument (ACTAEON Probe) was used to rapidly measure the stiffness of articular cartilage, which can then be correlated to cartilage condition. An integrated series of tests were performed to determine whether the Probe is sensitive enough to detect early degenerative changes in articular cartilage and to examine if it is dependent on the thickness of the cartilage being tested. Results demonstrated that there is no effect of thickness on the Probe measurements for clinically relevant human cartilage samples, that the Probe is sensitive enough to detect different levels of cartilage degeneration, and that Probe data correlate well with traditional creep indentation testing. 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| identifier | ISSN: 0090-6964 |
| ispartof | Annals of biomedical engineering, 2004-03, Vol.32 (3), p.352-359 |
| issn | 0090-6964 1573-9686 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Cadaver Cartilage Cartilage Diseases - classification Cartilage Diseases - diagnosis Cartilage Diseases - pathology Cartilage Diseases - physiopathology Cartilage, Articular - pathology Cartilage, Articular - physiopathology Diagnosis, Computer-Assisted - methods Elasticity Equipment Design Equipment Failure Analysis Goats Hardness Tests - instrumentation Hardness Tests - methods Humans In Vitro Techniques Knee Joint Miniaturization Papio Physical Examination - instrumentation Physical Examination - methods Physical Stimulation - instrumentation Physical Stimulation - methods Rabbits Sensitivity and Specificity Severity of Illness Index Species Specificity Statistics as Topic Stress, Mechanical |
| title | Correlation of cartilage stiffness to thickness and level of degeneration using a handheld indentation probe |
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