Tissue engineering of ovine aortic blood vessel substitutes using applied shear stress and enzymatically derived vascular smooth muscle cells

Compared to native blood vessels, all clinically available blood vessel substitutes perform suboptimally. Numerous approaches to tissue engineer (TE) blood vessels have been pursued using different scaffold materials, cell types, and culture conditions. Several limitations however remain to be overc...

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Veröffentlicht in:	Annals of biomedical engineering 2004-02, Vol.32 (2), p.212-222
Hauptverfasser:	Opitz, F, Schenke-Layland, K, Richter, W, Martin, D P, Degenkolbe, I, Wahlers, Th, Stock, U A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioreactors Blood vessels Blood Vessels - cytology Blood Vessels - growth & development Cell Culture Techniques - methods Cell Differentiation - physiology Cells, Cultured Collagenases - metabolism Elasticity Endopeptidases - metabolism Endothelial Cells - cytology Endothelial Cells - physiology Mechanotransduction, Cellular - physiology Muscle Contraction - physiology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - growth & development Muscular system Pancreatic Elastase Shear stress Sheep Stress, Mechanical Tensile Strength Tissue Engineering - methods Transplants
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