Quantitative rates of in vivo bone generation for Bioglass and hydroxyapatite particles as bone graft substitute
Rates of in vivo bone generation were characterized by point-counting analysis of particulate Bioglass and synthetic hydroxyapatite (HA) in rabbit femora. New bony tissue was observed in approximately 20% of the image area around Bioglass particles at 1 wk, and the degree of trabecular bone growth i...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 1997-11, Vol.8 (11), p.649-652 |
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| creator | Fujishiro, Y Hench, L L Oonishi, H |
| description | Rates of in vivo bone generation were characterized by point-counting analysis of particulate Bioglass and synthetic hydroxyapatite (HA) in rabbit femora. New bony tissue was observed in approximately 20% of the image area around Bioglass particles at 1 wk, and the degree of trabecular bone growth increased with time. The interparticle space of Bioglass was filled by 80% bonding bone between 6 and 12 wk. The rate constants of trabecular bone growth in the presence of Bioglass were approximately 10.9x10(-3) d(-1) at the periphery of the implantation site. HA particles led to smaller rate constants of approximately 4.6x10(-3) d(-1) at the periphery, and the HA particles developed very small amounts of bridging bone. The quantitative rate of bone growth matched well with previously measured bioactive indices of the materials. |
| doi_str_mv | 10.1023/a:1018527621356 |
| format | Article |
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New bony tissue was observed in approximately 20% of the image area around Bioglass particles at 1 wk, and the degree of trabecular bone growth increased with time. The interparticle space of Bioglass was filled by 80% bonding bone between 6 and 12 wk. The rate constants of trabecular bone growth in the presence of Bioglass were approximately 10.9x10(-3) d(-1) at the periphery of the implantation site. HA particles led to smaller rate constants of approximately 4.6x10(-3) d(-1) at the periphery, and the HA particles developed very small amounts of bridging bone. The quantitative rate of bone growth matched well with previously measured bioactive indices of the materials.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1023/a:1018527621356</identifier><identifier>PMID: 15348815</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Biomedical materials ; Bone ; Bones ; Glass ; Grafts ; Growth kinetics ; Hydroxyapatite ; Materials science ; Particles (particulate matter) ; Phosphate minerals</subject><ispartof>Journal of materials science. 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The quantitative rate of bone growth matched well with previously measured bioactive indices of the materials.</description><subject>Biomedical materials</subject><subject>Bone</subject><subject>Bones</subject><subject>Glass</subject><subject>Grafts</subject><subject>Growth kinetics</subject><subject>Hydroxyapatite</subject><subject>Materials science</subject><subject>Particles (particulate matter)</subject><subject>Phosphate minerals</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqF0T1vFDEQBmALgciRpE6HLAqoFuwbjz_okogvKRJCSr_yemcTR3vrje09cf-eRRxNCqimeJ95pdEwdiHFeym28MF_lEJa3Bq9lYD6GdtINNAoC_Y52wiHplEI4oS9KuVBCKEc4kt2IhGUtRI3bP6x-KnG6mvcE8--UuFp4HHi-7hPvEsT8TuaaE1imviQMr-K6W70pXA_9fz-0Of08-DnNa_EZ59rDONa4stxOfuh8rJ0ZQVLpTP2YvBjofPjPGW3nz_dXn9tbr5_-XZ9edMEJVxtrCCn-r4DCLAl0yOi7KQeJNnBBNIWBXYqeGcdemlCCAIC9YMm6iwgnLJ3f2rnnB4XKrXdxRJoHP1EaSmtBSmN0Fqv8u0_pbFGI2j3XyhROauFWOGbJ_AhLXlar20NalAO9G_0-oiWbkd9O-e48_nQ_n0N_AL7HZHI</recordid><startdate>19971101</startdate><enddate>19971101</enddate><creator>Fujishiro, Y</creator><creator>Hench, L L</creator><creator>Oonishi, H</creator><general>Springer Nature B.V</general><scope>NPM</scope><scope>3V.</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H8D</scope><scope>H8G</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0W</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>19971101</creationdate><title>Quantitative rates of in vivo bone generation for Bioglass and hydroxyapatite particles as bone graft substitute</title><author>Fujishiro, Y ; 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| issn | 0957-4530 1573-4838 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Biomedical materials Bone Bones Glass Grafts Growth kinetics Hydroxyapatite Materials science Particles (particulate matter) Phosphate minerals |
| title | Quantitative rates of in vivo bone generation for Bioglass and hydroxyapatite particles as bone graft substitute |
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