Shear stress differentially regulates PGHS-1 and PGHS-2 protein levels in human endothelial cells

The secretion of prostacyclin (PGI2) by endothelial cells is regulated by shear stress. Prostaglandin H synthase (PGHS) is considered to be a key limiting enzyme in the synthesis of PGI2 from arachidonic acid. Endothelial cells were cultured in the presence of 4, 15, or 25 dyn/cm2 shear stress using...

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Veröffentlicht in:	Annals of biomedical engineering 2000-07, Vol.28 (7), p.824-833
Hauptverfasser:	McCormick, S M, Whitson, P A, Wu, K K, McIntire, L V
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cells, Cultured Endothelium, Vascular - chemistry Endothelium, Vascular - cytology Epoprostenol - metabolism Gene Expression Regulation - physiology Hemorheology Homeostasis Humans Ischemic Preconditioning - methods Prostaglandin-Endoperoxide Synthases - analysis Prostaglandin-Endoperoxide Synthases - physiology Shear stress Space life sciences Stress Stress, Mechanical Time Factors Umbilical Cord - cytology
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