Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate
Gelatin nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, scanning electron microscopy (SEM) and particle size analysis. The prepared nanoparticles were loaded with chloroquine phosphate (CP), a well known antimalarial drug, and the release dy...
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| Veröffentlicht in: | Journal of materials science. Materials in medicine 2006-04, Vol.17 (4), p.345-358 |
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| creator | Bajpai, A K Choubey, Jyoti |
| description | Gelatin nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, scanning electron microscopy (SEM) and particle size analysis. The prepared nanoparticles were loaded with chloroquine phosphate (CP), a well known antimalarial drug, and the release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium. The nanoparticles were also studied for their water sorption capacity by optical microscopic method taking advantage of the aggregation of nanoparticles. The drug release processes was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles. |
| doi_str_mv | 10.1007/s10856-006-8235-9 |
| format | Article |
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The prepared nanoparticles were loaded with chloroquine phosphate (CP), a well known antimalarial drug, and the release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium. The nanoparticles were also studied for their water sorption capacity by optical microscopic method taking advantage of the aggregation of nanoparticles. The drug release processes was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles.</description><identifier>ISSN: 0957-4530</identifier><identifier>EISSN: 1573-4838</identifier><identifier>DOI: 10.1007/s10856-006-8235-9</identifier><identifier>PMID: 16617413</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Absorption ; Biomedical materials ; Chloroquine - administration & dosage ; Chloroquine - analogs & derivatives ; Chloroquine - chemistry ; Delayed-Action Preparations - administration & dosage ; Delayed-Action Preparations - chemistry ; Delivery systems ; Diffusion ; Drug Stability ; Drugs ; Gelatin - chemistry ; Gelatins ; Kinetics ; Loads (forces) ; Materials science ; Molecular Conformation ; Nanoparticles ; Nanostructure ; Nanostructures - chemistry ; Nanostructures - ultrastructure ; Particle Size ; Phosphates ; Scanning electron microscopy ; Swelling</subject><ispartof>Journal of materials science. 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Materials in medicine</title><addtitle>J Mater Sci Mater Med</addtitle><description>Gelatin nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, scanning electron microscopy (SEM) and particle size analysis. The prepared nanoparticles were loaded with chloroquine phosphate (CP), a well known antimalarial drug, and the release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium. The nanoparticles were also studied for their water sorption capacity by optical microscopic method taking advantage of the aggregation of nanoparticles. The drug release processes was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles.</description><subject>Absorption</subject><subject>Biomedical materials</subject><subject>Chloroquine - administration & dosage</subject><subject>Chloroquine - analogs & derivatives</subject><subject>Chloroquine - chemistry</subject><subject>Delayed-Action Preparations - administration & dosage</subject><subject>Delayed-Action Preparations - chemistry</subject><subject>Delivery systems</subject><subject>Diffusion</subject><subject>Drug Stability</subject><subject>Drugs</subject><subject>Gelatin - chemistry</subject><subject>Gelatins</subject><subject>Kinetics</subject><subject>Loads (forces)</subject><subject>Materials science</subject><subject>Molecular Conformation</subject><subject>Nanoparticles</subject><subject>Nanostructure</subject><subject>Nanostructures - chemistry</subject><subject>Nanostructures - ultrastructure</subject><subject>Particle Size</subject><subject>Phosphates</subject><subject>Scanning electron microscopy</subject><subject>Swelling</subject><issn>0957-4530</issn><issn>1573-4838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkT2P1DAQhi0E4paFH0CDLAqgCXji7_J0fEon0UBtnGS8m5M3DnYWtP8eR7sSEsVRTfPMM6_mJeQ5sLfAmH5XgBmpGsZUY1ouG_uAbEBq3gjDzUOyYVbqRkjOrsiTUu4YY8JK-ZhcgVKgBfAN-fEey7ibaAp0h9Ev40QnP6XZ52XsIxbqCy2_McZx2tE-TUtOMeJAB4zjL8wnWk5lwQMNKdN-H1NOP4_jhHTepzLv_YJPyaPgY8Fnl7kl3z9--Hbzubn9-unLzfVt09eAS9NqjYP1SmgQwQSmNJfIWceQg7EQjGitBR0AbaeNGdohhE56jiZ0olecb8nrs3deI2BZ3GEsfQ3uJ0zH4gwHUFpzVclX95Kt5bbVRv4fZFoqVp1b8uZeEJRoV6tdj7_8B71LxzzVz7gqE0ppCRWCM9TnVErG4OY8Hnw-OWBubd6dm3e1ebc272zdeXERH7sDDn83LlXzP2TTqQM</recordid><startdate>200604</startdate><enddate>200604</enddate><creator>Bajpai, A K</creator><creator>Choubey, 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| ispartof | Journal of materials science. Materials in medicine, 2006-04, Vol.17 (4), p.345-358 |
| issn | 0957-4530 1573-4838 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Absorption Biomedical materials Chloroquine - administration & dosage Chloroquine - analogs & derivatives Chloroquine - chemistry Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delivery systems Diffusion Drug Stability Drugs Gelatin - chemistry Gelatins Kinetics Loads (forces) Materials science Molecular Conformation Nanoparticles Nanostructure Nanostructures - chemistry Nanostructures - ultrastructure Particle Size Phosphates Scanning electron microscopy Swelling |
| title | Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate |
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