Increase in rat brain acetylcholine induced by choline or deanol
Administration of choline chloride, deanol, or Deaner ® to rats subsequently killed by microwave irradiation caused an increase in the concentration of both choline and acetylcholine in the corpus striatum, indicating that synthesis of brain acetylcholine can be stimulated in vivo by elevating the t...
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| Veröffentlicht in: | Life sciences (1973) 1975-09, Vol.17 (6), p.975-980 |
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| container_end_page | 980 |
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| container_issue | 6 |
| container_start_page | 975 |
| container_title | Life sciences (1973) |
| container_volume | 17 |
| creator | Haubrich, Dean R. Wang, Paulina F.L. Clody, Donald E. Wedeking, Paul W. |
| description | Administration of choline chloride, deanol, or Deaner ® to rats subsequently killed by microwave irradiation caused an increase in the concentration of both choline and acetylcholine in the corpus striatum, indicating that synthesis of brain acetylcholine can be stimulated
in vivo by elevating the tissue concentration of its precursor. This finding suggests that the concentration of free choline in brain is below that necessary for a maximal rate of synthesis of acetylcholine, and raises the possibility that the availability of choline in brain may regulate the rate of synthesis of acetylcholine. These results also provide biochemical evidence for the view that the clinical effects of deanol result from its conversion to acetylcholine. |
| doi_str_mv | 10.1016/0024-3205(75)90451-8 |
| format | Article |
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in vivo by elevating the tissue concentration of its precursor. This finding suggests that the concentration of free choline in brain is below that necessary for a maximal rate of synthesis of acetylcholine, and raises the possibility that the availability of choline in brain may regulate the rate of synthesis of acetylcholine. These results also provide biochemical evidence for the view that the clinical effects of deanol result from its conversion to acetylcholine.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(75)90451-8</identifier><identifier>PMID: 1195991</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Acetylcholine - biosynthesis ; Animals ; Choline - biosynthesis ; Choline - blood ; Choline - pharmacology ; Corpus Striatum - drug effects ; Corpus Striatum - metabolism ; Deanol - analogs & derivatives ; Deanol - pharmacology ; Dose-Response Relationship, Drug ; Ethanolamines - pharmacology ; Male ; Rats ; Time Factors</subject><ispartof>Life sciences (1973), 1975-09, Vol.17 (6), p.975-980</ispartof><rights>1975</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-621714b3f0a8cd8a9e3a52111ef78ef9771bb1f79b4f54bf24df8874e01275cf3</citedby><cites>FETCH-LOGICAL-c357t-621714b3f0a8cd8a9e3a52111ef78ef9771bb1f79b4f54bf24df8874e01275cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(75)90451-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1195991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haubrich, Dean R.</creatorcontrib><creatorcontrib>Wang, Paulina F.L.</creatorcontrib><creatorcontrib>Clody, Donald E.</creatorcontrib><creatorcontrib>Wedeking, Paul W.</creatorcontrib><title>Increase in rat brain acetylcholine induced by choline or deanol</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Administration of choline chloride, deanol, or Deaner ® to rats subsequently killed by microwave irradiation caused an increase in the concentration of both choline and acetylcholine in the corpus striatum, indicating that synthesis of brain acetylcholine can be stimulated
in vivo by elevating the tissue concentration of its precursor. This finding suggests that the concentration of free choline in brain is below that necessary for a maximal rate of synthesis of acetylcholine, and raises the possibility that the availability of choline in brain may regulate the rate of synthesis of acetylcholine. These results also provide biochemical evidence for the view that the clinical effects of deanol result from its conversion to acetylcholine.</description><subject>Acetylcholine - biosynthesis</subject><subject>Animals</subject><subject>Choline - biosynthesis</subject><subject>Choline - blood</subject><subject>Choline - pharmacology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Deanol - analogs & derivatives</subject><subject>Deanol - pharmacology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanolamines - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Time Factors</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1UM22ySS6iLP5ZWPCi55CkE6x02zVphf32tnbVm6cZ5r03w_wIOQV6BRTm15RmLM0zyi8Ev1SUcUjlHpmCFCql8xz2yfTXckiOYnynlHIu8gmZACiuFEzJ7bJ2AU3EpKyTYNrEBtN3xmG7rdxbU5X1IBWdwyKx2-Rn1ISkQFM31TE58KaKeLKrM_L6cP-yeEpXz4_Lxd0qdTkXbTrPQACzuadGukIahbnhGQCgFxK9EgKsBS-UZZ4z6zNWeCkFQwqZ4M7nM3I-7t2E5qPD2Op1GR1Wlamx6aKWOQCDTPZGNhpdaGIM6PUmlGsTthqoHsDpgYoeqGjB9Tc4PcTOdvs7u8biLzSS6vWbUcf-yc8Sg46uxLrHUgZ0rS6a8v8DXylYe7U</recordid><startdate>19750915</startdate><enddate>19750915</enddate><creator>Haubrich, Dean R.</creator><creator>Wang, Paulina F.L.</creator><creator>Clody, Donald E.</creator><creator>Wedeking, Paul W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19750915</creationdate><title>Increase in rat brain acetylcholine induced by choline or deanol</title><author>Haubrich, Dean R. ; Wang, Paulina F.L. ; Clody, Donald E. ; Wedeking, Paul W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-621714b3f0a8cd8a9e3a52111ef78ef9771bb1f79b4f54bf24df8874e01275cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Acetylcholine - biosynthesis</topic><topic>Animals</topic><topic>Choline - biosynthesis</topic><topic>Choline - blood</topic><topic>Choline - pharmacology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Deanol - analogs & derivatives</topic><topic>Deanol - pharmacology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanolamines - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haubrich, Dean R.</creatorcontrib><creatorcontrib>Wang, Paulina F.L.</creatorcontrib><creatorcontrib>Clody, Donald E.</creatorcontrib><creatorcontrib>Wedeking, Paul W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haubrich, Dean R.</au><au>Wang, Paulina F.L.</au><au>Clody, Donald E.</au><au>Wedeking, Paul W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increase in rat brain acetylcholine induced by choline or deanol</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1975-09-15</date><risdate>1975</risdate><volume>17</volume><issue>6</issue><spage>975</spage><epage>980</epage><pages>975-980</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Administration of choline chloride, deanol, or Deaner ® to rats subsequently killed by microwave irradiation caused an increase in the concentration of both choline and acetylcholine in the corpus striatum, indicating that synthesis of brain acetylcholine can be stimulated
in vivo by elevating the tissue concentration of its precursor. This finding suggests that the concentration of free choline in brain is below that necessary for a maximal rate of synthesis of acetylcholine, and raises the possibility that the availability of choline in brain may regulate the rate of synthesis of acetylcholine. These results also provide biochemical evidence for the view that the clinical effects of deanol result from its conversion to acetylcholine.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>1195991</pmid><doi>10.1016/0024-3205(75)90451-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1975-09, Vol.17 (6), p.975-980 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83114128 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholine - biosynthesis Animals Choline - biosynthesis Choline - blood Choline - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Deanol - analogs & derivatives Deanol - pharmacology Dose-Response Relationship, Drug Ethanolamines - pharmacology Male Rats Time Factors |
| title | Increase in rat brain acetylcholine induced by choline or deanol |
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