Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C
Marked changes in physical appearance manifested by dry formulations containing aspirin, an antihistamine, and vitamin C during an accelerated temperature stability study are discussed. The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted. Discrepanc...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1962-11, Vol.51 (11), p.1068-1071 |
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| container_end_page | 1071 |
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| container_issue | 11 |
| container_start_page | 1068 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 51 |
| creator | Siegel, Sheldon Reiner, Roy H. Zelinskie, James A. Hanus, Edward J. |
| description | Marked changes in physical appearance manifested by dry formulations containing aspirin, an antihistamine, and vitamin C during an accelerated temperature stability study are discussed. The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted. Discrepancies in the results obtained from stability studies of these preparations have been traced to the efficiency of the closure utilized in the packaging of the product, as well as the methods employed in the pretreatment, sampling, and evaluation of test samples. The implications of these observations from a developmental standpoint are discussed. |
| doi_str_mv | 10.1002/jps.2600511112 |
| format | Article |
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The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted. Discrepancies in the results obtained from stability studies of these preparations have been traced to the efficiency of the closure utilized in the packaging of the product, as well as the methods employed in the pretreatment, sampling, and evaluation of test samples. The implications of these observations from a developmental standpoint are discussed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600511112</identifier><identifier>PMID: 13988963</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Anti-Allergic Agents ; Ascorbic Acid ; Aspirin ; Chemistry, Pharmaceutical ; Histamine H1 Antagonists ; Old Medline ; Pyrilamine ; Resins, Synthetic ; Tablets ; Vitamins</subject><ispartof>Journal of pharmaceutical sciences, 1962-11, Vol.51 (11), p.1068-1071</ispartof><rights>1962 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1962 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4282-deecd437407122742b0ac004aa249189f86594b279f70088d41321d09e976cf63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600511112$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600511112$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13988963$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siegel, Sheldon</creatorcontrib><creatorcontrib>Reiner, Roy H.</creatorcontrib><creatorcontrib>Zelinskie, James A.</creatorcontrib><creatorcontrib>Hanus, Edward J.</creatorcontrib><title>Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Marked changes in physical appearance manifested by dry formulations containing aspirin, an antihistamine, and vitamin C during an accelerated temperature stability study are discussed. The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted. Discrepancies in the results obtained from stability studies of these preparations have been traced to the efficiency of the closure utilized in the packaging of the product, as well as the methods employed in the pretreatment, sampling, and evaluation of test samples. The implications of these observations from a developmental standpoint are discussed.</description><subject>Anti-Allergic Agents</subject><subject>Ascorbic Acid</subject><subject>Aspirin</subject><subject>Chemistry, Pharmaceutical</subject><subject>Histamine H1 Antagonists</subject><subject>Old Medline</subject><subject>Pyrilamine</subject><subject>Resins, Synthetic</subject><subject>Tablets</subject><subject>Vitamins</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7rh69Sh98tZj5aPzcXMYdFSWddBVwUtIJ9WYtad7THpc59-bpQcXD2JdCornfaEeQp5SWFIA9uJ6n5dMAjS0DLtHFrRhUEug6j5ZFIDVvBHmjDzK-RoAJDTNQ3JGudHaSL4gL69c2-OUq7GrtscUe7eLA1YfMMehWoU8ptZNWN3E6Vu1yvuYytkNofocp1uyWj8mDzrXZ3xy2ufk0-tXV-s39cX7zdv16qL2gmlWB0QfBFcCFGVMCdaC8wDCOSYM1abTsjGiZcp0CkDrIChnNIBBo6TvJD8nz-fefRp_HDBPdhezx753A46HbDWnYAxXBVzOoE9jzgk7u09x59LRUrC3zmxxZu-clcCzU_Oh3WG4w0-SCmBm4Cb2ePxPnX23_fhXeT1nY57w15-sS9-tVFw19svlxl5KteGaf7XbwuuZx-LyZ8Rks484eAwxoZ9sGOO__vgNozOXQQ</recordid><startdate>196211</startdate><enddate>196211</enddate><creator>Siegel, Sheldon</creator><creator>Reiner, Roy H.</creator><creator>Zelinskie, James A.</creator><creator>Hanus, Edward J.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196211</creationdate><title>Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C</title><author>Siegel, Sheldon ; Reiner, Roy H. ; Zelinskie, James A. ; Hanus, Edward J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4282-deecd437407122742b0ac004aa249189f86594b279f70088d41321d09e976cf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Anti-Allergic Agents</topic><topic>Ascorbic Acid</topic><topic>Aspirin</topic><topic>Chemistry, Pharmaceutical</topic><topic>Histamine H1 Antagonists</topic><topic>Old Medline</topic><topic>Pyrilamine</topic><topic>Resins, Synthetic</topic><topic>Tablets</topic><topic>Vitamins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siegel, Sheldon</creatorcontrib><creatorcontrib>Reiner, Roy H.</creatorcontrib><creatorcontrib>Zelinskie, James A.</creatorcontrib><creatorcontrib>Hanus, Edward J.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siegel, Sheldon</au><au>Reiner, Roy H.</au><au>Zelinskie, James A.</au><au>Hanus, Edward J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1962-11</date><risdate>1962</risdate><volume>51</volume><issue>11</issue><spage>1068</spage><epage>1071</epage><pages>1068-1071</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Marked changes in physical appearance manifested by dry formulations containing aspirin, an antihistamine, and vitamin C during an accelerated temperature stability study are discussed. The stabilization afforded by a resin adsorbate of a commonly used antihistamine, pyrilamine, is noted. Discrepancies in the results obtained from stability studies of these preparations have been traced to the efficiency of the closure utilized in the packaging of the product, as well as the methods employed in the pretreatment, sampling, and evaluation of test samples. 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| ispartof | Journal of pharmaceutical sciences, 1962-11, Vol.51 (11), p.1068-1071 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Anti-Allergic Agents Ascorbic Acid Aspirin Chemistry, Pharmaceutical Histamine H1 Antagonists Old Medline Pyrilamine Resins, Synthetic Tablets Vitamins |
| title | Tablets of Pyrilamine Resin Adsorbate with Aspirin and Vitamin C |
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