The Conformational Oscillation of δ‐Chymotrypsin Involvement of Methionine‐192

In δ‐chymotrypsin the reactivity of methionine‐192 towards p‐nitrophenacyl bromide is strongly reduced when the α‐amino group of isoleucine‐16 has been acetylated. Since acetylation of isoleucine‐16 brings δ‐chymotrypsin to a conformation similar to its alkaline one this suggests that methionine‐192...

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Veröffentlicht in:	European journal of biochemistry 1975-11, Vol.59 (1), p.159-166
Hauptverfasser:	GHELIS, Charis, LABOUESSE, Julie, LABOUESSE, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Chymotrypsin - analysis Chymotrypsinogen Circular Dichroism Hydrogen-Ion Concentration Isoleucine - analysis Kinetics Methionine - analysis Nitrophenols Optical Rotation Protein Binding Protein Conformation Trypsin
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