Hepatitis B Virus Infection in Chimpanzees: Titration of Subtypes
Thirty-four chimpanzees were inoculated with sera containing the adw, ayw, adr, or ayr subtype of hepatitis B surface antigen (HBs Ag). Twenty-nine of the animals became infected with hepatitis B virus, and in every instance the subtype of HBs Ag in the infected animal was the same as the subtype in...
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| Veröffentlicht in: | The Journal of infectious diseases 1975-10, Vol.132 (4), p.451-458 |
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| container_end_page | 458 |
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| container_issue | 4 |
| container_start_page | 451 |
| container_title | The Journal of infectious diseases |
| container_volume | 132 |
| creator | Barker, Lewellys F. Maynard, James E. Purcell, Robert H. Hoofnagle, Jay H. Berquist, Kenneth R. London, William T. Gerety, Robert J. Krushak, Donald H. |
| description | Thirty-four chimpanzees were inoculated with sera containing the adw, ayw, adr, or ayr subtype of hepatitis B surface antigen (HBs Ag). Twenty-nine of the animals became infected with hepatitis B virus, and in every instance the subtype of HBs Ag in the infected animal was the same as the subtype in the inoculum. Infectivity titers were established for the adw and ayw inocula. The patterns of serologic events varied in the infected animals but included most of the typical patterns of serologic change seen in human cases of type B hepatitis. Mild disease, manifested by elevated concentrations of serum enzymes and changes detected by liver biopsy, occurred in 23 of the 29 infected animals. |
| doi_str_mv | 10.1093/infdis/132.4.451 |
| format | Article |
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Twenty-nine of the animals became infected with hepatitis B virus, and in every instance the subtype of HBs Ag in the infected animal was the same as the subtype in the inoculum. Infectivity titers were established for the adw and ayw inocula. The patterns of serologic events varied in the infected animals but included most of the typical patterns of serologic change seen in human cases of type B hepatitis. Mild disease, manifested by elevated concentrations of serum enzymes and changes detected by liver biopsy, occurred in 23 of the 29 infected animals.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/132.4.451</identifier><identifier>PMID: 1185011</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Animals ; Antibodies ; Enzymes ; Hepatitis ; Hepatitis antigens ; Hepatitis B - immunology ; Hepatitis B Antigens ; Hepatitis B virus ; Infections ; Inoculation ; Major Articles ; Pan troglodytes - immunology ; Radioimmunoassay ; Viruses</subject><ispartof>The Journal of infectious diseases, 1975-10, Vol.132 (4), p.451-458</ispartof><rights>Copyright 1975 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-d675c692156fb4bc585a36539b5197906e56e1ad073d0509d759d9f256086f1b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30106196$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30106196$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1185011$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barker, Lewellys F.</creatorcontrib><creatorcontrib>Maynard, James E.</creatorcontrib><creatorcontrib>Purcell, Robert H.</creatorcontrib><creatorcontrib>Hoofnagle, Jay H.</creatorcontrib><creatorcontrib>Berquist, Kenneth R.</creatorcontrib><creatorcontrib>London, William T.</creatorcontrib><creatorcontrib>Gerety, Robert J.</creatorcontrib><creatorcontrib>Krushak, Donald H.</creatorcontrib><title>Hepatitis B Virus Infection in Chimpanzees: Titration of Subtypes</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Thirty-four chimpanzees were inoculated with sera containing the adw, ayw, adr, or ayr subtype of hepatitis B surface antigen (HBs Ag). 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Mild disease, manifested by elevated concentrations of serum enzymes and changes detected by liver biopsy, occurred in 23 of the 29 infected animals.</description><subject>Animals</subject><subject>Antibodies</subject><subject>Enzymes</subject><subject>Hepatitis</subject><subject>Hepatitis antigens</subject><subject>Hepatitis B - immunology</subject><subject>Hepatitis B Antigens</subject><subject>Hepatitis B virus</subject><subject>Infections</subject><subject>Inoculation</subject><subject>Major Articles</subject><subject>Pan troglodytes - immunology</subject><subject>Radioimmunoassay</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDFPwzAUhC0EKqWwsyBlYkt5L46dmA0qoIVKCLUgxGI5iSMMbRJsR6L8egKpYLrhu7vhI-QYYYwg6JmpysK4M6TROB7HDHfIEBlNQs6R7pIhQBSFmAqxTw6cewOAmPJkQAaIKQPEIbmY6kZ5440LLoMnY1sXzKpS597UVWCqYPJq1o2qvrR258HSeKt-SV0Gizbzm0a7Q7JXqpXTR9sckcfrq-VkGs7vb2aTi3mYUxb7sOAJy7mIkPEyi7OcpUxRzqjIGIpEANeMa1QFJLQABqJImChEGTEOKS8xoyNy2v82tv5otfNybVyuVytV6bp1MqUgfv67IvTF3NbOWV3Kxpq1shuJIH-syd6a7KzJWHbWusnJ9rvN1rr4H_Sa_vmb87X9wxQQOAre8bDnxnn9-ceVfZc8oQmT0-cXuZgv7uLl7a18oN-NHIDn</recordid><startdate>197510</startdate><enddate>197510</enddate><creator>Barker, Lewellys F.</creator><creator>Maynard, James E.</creator><creator>Purcell, Robert H.</creator><creator>Hoofnagle, Jay H.</creator><creator>Berquist, Kenneth R.</creator><creator>London, William T.</creator><creator>Gerety, Robert J.</creator><creator>Krushak, Donald H.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197510</creationdate><title>Hepatitis B Virus Infection in Chimpanzees: Titration of Subtypes</title><author>Barker, Lewellys F. ; Maynard, James E. ; Purcell, Robert H. ; Hoofnagle, Jay H. ; Berquist, Kenneth R. ; London, William T. ; Gerety, Robert J. ; Krushak, Donald H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-d675c692156fb4bc585a36539b5197906e56e1ad073d0509d759d9f256086f1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Antibodies</topic><topic>Enzymes</topic><topic>Hepatitis</topic><topic>Hepatitis antigens</topic><topic>Hepatitis B - immunology</topic><topic>Hepatitis B Antigens</topic><topic>Hepatitis B virus</topic><topic>Infections</topic><topic>Inoculation</topic><topic>Major Articles</topic><topic>Pan troglodytes - immunology</topic><topic>Radioimmunoassay</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barker, Lewellys F.</creatorcontrib><creatorcontrib>Maynard, James E.</creatorcontrib><creatorcontrib>Purcell, Robert H.</creatorcontrib><creatorcontrib>Hoofnagle, Jay H.</creatorcontrib><creatorcontrib>Berquist, Kenneth R.</creatorcontrib><creatorcontrib>London, William T.</creatorcontrib><creatorcontrib>Gerety, Robert J.</creatorcontrib><creatorcontrib>Krushak, Donald H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barker, Lewellys F.</au><au>Maynard, James E.</au><au>Purcell, Robert H.</au><au>Hoofnagle, Jay H.</au><au>Berquist, Kenneth R.</au><au>London, William T.</au><au>Gerety, Robert J.</au><au>Krushak, Donald H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B Virus Infection in Chimpanzees: Titration of Subtypes</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1975-10</date><risdate>1975</risdate><volume>132</volume><issue>4</issue><spage>451</spage><epage>458</epage><pages>451-458</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Thirty-four chimpanzees were inoculated with sera containing the adw, ayw, adr, or ayr subtype of hepatitis B surface antigen (HBs Ag). Twenty-nine of the animals became infected with hepatitis B virus, and in every instance the subtype of HBs Ag in the infected animal was the same as the subtype in the inoculum. Infectivity titers were established for the adw and ayw inocula. The patterns of serologic events varied in the infected animals but included most of the typical patterns of serologic change seen in human cases of type B hepatitis. Mild disease, manifested by elevated concentrations of serum enzymes and changes detected by liver biopsy, occurred in 23 of the 29 infected animals.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>1185011</pmid><doi>10.1093/infdis/132.4.451</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1975-10, Vol.132 (4), p.451-458 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83096921 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Antibodies Enzymes Hepatitis Hepatitis antigens Hepatitis B - immunology Hepatitis B Antigens Hepatitis B virus Infections Inoculation Major Articles Pan troglodytes - immunology Radioimmunoassay Viruses |
| title | Hepatitis B Virus Infection in Chimpanzees: Titration of Subtypes |
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