EFFECT OF PENTOBARBITONE ON HYPOXIC VENTILATORY DRIVE IN MAN: Preliminary study

EFFECT OF PENTOBARBITONE ON HYPOXIC VENTILATORY DRIVE IN MAN: Preliminary study

The effect of an intramuscular injection of pentobarbitone 2 mg/kg on the hypoxic ventilatory drive was measured in 10 volunteers. Five subjects showed significant depression of the ventilatory response to hypoxia 30 min after administration. This depression persisted for 90 min. The other five subj...

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Veröffentlicht in:British journal of anaesthesia : BJA 1975-09, Vol.47 (9), p.963-968
Hauptverfasser: HlRSHMAN, C.A., McCULLOUGH, R.E., COHEN, P.J., WEIL, J.V.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Female
Heart Rate - drug effects
Humans
Hypoxia - physiopathology
Male
Oxygen Consumption - drug effects
Pentobarbital - pharmacology
Physical Fitness
Respiration - drug effects
Space life sciences
Time Factors
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Zusammenfassung:The effect of an intramuscular injection of pentobarbitone 2 mg/kg on the hypoxic ventilatory drive was measured in 10 volunteers. Five subjects showed significant depression of the ventilatory response to hypoxia 30 min after administration. This depression persisted for 90 min. The other five subjects showed no change from control responses. The two groups appeared to differ in their levels of physical fitness as measured by differences in resting heart rate and maximal oxygen uptake.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/47.9.963