Retention of Nonhelical Procollagen Containing cis-Hydroxyproline in Rough Endoplasmic Reticulum
Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. Evidence is presented here that the nonhelical procollagen containing the...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1975-12, Vol.190 (4220), p.1202-1204 |
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| container_issue | 4220 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Uitto, Jouni Hoffmann, Hans-Peter Prockop, Darwin J. |
| description | Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate. |
| doi_str_mv | 10.1126/science.1198105 |
| format | Article |
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Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1198105</identifier><identifier>PMID: 1198105</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Biochemistry ; Biological Transport ; Cell membranes ; Chick Embryo ; Collagen - metabolism ; Collagens ; Diploidy ; Endoplasmic Reticulum - metabolism ; Fibroblasts - metabolism ; Fibroblasts - ultrastructure ; Hydroxyproline - metabolism ; Luminescence ; Protein Conformation ; Protein Precursors - metabolism ; Rough endoplasmic reticulum ; Smooth endoplasmic reticulum ; Somatic cells ; Structure-Activity Relationship ; Tendons ; Tendons - embryology ; Tendons - metabolism ; Vacuoles</subject><ispartof>Science (American Association for the Advancement of Science), 1975-12, Vol.190 (4220), p.1202-1204</ispartof><rights>Copyright 1975 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-cf27db3d99a9d3b55012e9fba0ca1f0692e493bdbfbd309ac02b8b18b9a685723</citedby><cites>FETCH-LOGICAL-c344t-cf27db3d99a9d3b55012e9fba0ca1f0692e493bdbfbd309ac02b8b18b9a685723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1742071$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1742071$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,2885,2886,27928,27929,58021,58254</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1198105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uitto, Jouni</creatorcontrib><creatorcontrib>Hoffmann, Hans-Peter</creatorcontrib><creatorcontrib>Prockop, Darwin J.</creatorcontrib><title>Retention of Nonhelical Procollagen Containing cis-Hydroxyproline in Rough Endoplasmic Reticulum</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Fibroblasts freshly isolated from embryonic tendons were incubated with a proline analog, cis-4-hydroxy-L-proline, which is incorporated into protein and which leads to the intracellular accumulation of nonhelical procollagen. 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Evidence is presented here that the nonhelical procollagen containing the analog is retained within the rough endoplasmic reticulum and does not pass to the smooth endoplasmic reticulum or Golgi vacuoles at a normal rate.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>1198105</pmid><doi>10.1126/science.1198105</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1975-12, Vol.190 (4220), p.1202-1204 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83084901 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Animals Biochemistry Biological Transport Cell membranes Chick Embryo Collagen - metabolism Collagens Diploidy Endoplasmic Reticulum - metabolism Fibroblasts - metabolism Fibroblasts - ultrastructure Hydroxyproline - metabolism Luminescence Protein Conformation Protein Precursors - metabolism Rough endoplasmic reticulum Smooth endoplasmic reticulum Somatic cells Structure-Activity Relationship Tendons Tendons - embryology Tendons - metabolism Vacuoles |
| title | Retention of Nonhelical Procollagen Containing cis-Hydroxyproline in Rough Endoplasmic Reticulum |
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