Rapid Regeneration Of The Dermal-Epidermal Junction After Partial Separation By Vacuum: An Electron Microscopic Study
A process of rapid repair of dermal-epidermal adherence, as found in experiments with interrupted suction, was investigated electron microscopically. Biopsies in different stages of the process of suction blister formation and of the repair process were studied. Results show that suction blister for...
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| Veröffentlicht in: | Journal of investigative dermatology 1975-12, Vol.65 (6), p.513-521 |
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| container_title | Journal of investigative dermatology |
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| creator | Beerens, E.G.J Slot, J.W Van Der Leun, J.C |
| description | A process of rapid repair of dermal-epidermal adherence, as found in experiments with interrupted suction, was investigated electron microscopically. Biopsies in different stages of the process of suction blister formation and of the repair process were studied. Results show that suction blister formation occurs by successive detachment of hemidesmosomes from the basement membrane, and that, after partial separation of the epidermis from the dermis, a rapid regeneration of the dermal-epidermal junction takes place. This regeneration process apparently consists of two steps: realignment of basal cells to the basement membrane accompanied by autophagocytosis of detached hemidesmosomes, and de novo formation of hemidesmosomes. The time required for this structural regeneration corresponds well with the speed of the functional repair of dermal-epidermal adherence measured with the technique of interrupted suction. |
| doi_str_mv | 10.1111/1523-1747.ep12610200 |
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Biopsies in different stages of the process of suction blister formation and of the repair process were studied. Results show that suction blister formation occurs by successive detachment of hemidesmosomes from the basement membrane, and that, after partial separation of the epidermis from the dermis, a rapid regeneration of the dermal-epidermal junction takes place. This regeneration process apparently consists of two steps: realignment of basal cells to the basement membrane accompanied by autophagocytosis of detached hemidesmosomes, and de novo formation of hemidesmosomes. The time required for this structural regeneration corresponds well with the speed of the functional repair of dermal-epidermal adherence measured with the technique of interrupted suction.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/1523-1747.ep12610200</identifier><identifier>PMID: 1194715</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Blister - pathology ; Blister - physiopathology ; Desmosomes - ultrastructure ; Edema ; Humans ; Intercellular Junctions - ultrastructure ; Male ; Microscopy, Electron ; Regeneration ; Skin - injuries ; Skin - physiopathology ; Skin - ultrastructure ; Vacuoles - ultrastructure</subject><ispartof>Journal of investigative dermatology, 1975-12, Vol.65 (6), p.513-521</ispartof><rights>1975 The Williams & Wilkins Co.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-b9643f0636b4ccd35ba79a4afb69bbb15c48c3b83efd4e6491070f951bccc38b3</citedby><cites>FETCH-LOGICAL-c498t-b9643f0636b4ccd35ba79a4afb69bbb15c48c3b83efd4e6491070f951bccc38b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1194715$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beerens, E.G.J</creatorcontrib><creatorcontrib>Slot, J.W</creatorcontrib><creatorcontrib>Van Der Leun, J.C</creatorcontrib><title>Rapid Regeneration Of The Dermal-Epidermal Junction After Partial Separation By Vacuum: An Electron Microscopic Study</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>A process of rapid repair of dermal-epidermal adherence, as found in experiments with interrupted suction, was investigated electron microscopically. Biopsies in different stages of the process of suction blister formation and of the repair process were studied. Results show that suction blister formation occurs by successive detachment of hemidesmosomes from the basement membrane, and that, after partial separation of the epidermis from the dermis, a rapid regeneration of the dermal-epidermal junction takes place. This regeneration process apparently consists of two steps: realignment of basal cells to the basement membrane accompanied by autophagocytosis of detached hemidesmosomes, and de novo formation of hemidesmosomes. The time required for this structural regeneration corresponds well with the speed of the functional repair of dermal-epidermal adherence measured with the technique of interrupted suction.</description><subject>Adult</subject><subject>Blister - pathology</subject><subject>Blister - physiopathology</subject><subject>Desmosomes - ultrastructure</subject><subject>Edema</subject><subject>Humans</subject><subject>Intercellular Junctions - ultrastructure</subject><subject>Male</subject><subject>Microscopy, Electron</subject><subject>Regeneration</subject><subject>Skin - injuries</subject><subject>Skin - physiopathology</subject><subject>Skin - ultrastructure</subject><subject>Vacuoles - ultrastructure</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kElvGyEUx1HUKHXSfINW4tTbODAwWw-VHMfZlMqR41a9IXjzpqWaLTATyd8-eFFzCxfQf3nAj5DPnE15WBc8iUXEM5lNsedxylnM2BGZ_Jc_kAljcRzFLP79kZx6_48xnsokPyEnnBcy48mEjCvd25Ku8A-26PRgu5YuK7r-i_QKXaPraBH83Ynejy3sArNqQEcftRtskJ-w14fm5Yb-0jCOzTc6a-miRhhckH9YcJ2HrrdAn4ax3Hwix5WuPZ4f9jPy83qxnt9GD8ubu_nsIQJZ5ENkilSKiqUiNRKgFInRWaGlrkxaGGN4AjIHYXKBVSkxlQVnGauKhBsAELkRZ-Trfm7vuucR_aAa6wHrWrfYjV7lguVxykQIyn1w-1DvsFK9s412G8WZ2tJWW6xqi1W90Q61L4f5o2mwfCvt8Qb_-97H8MkXi055sNgCltYFNqrs7PsXvAJ6Q4_x</recordid><startdate>197512</startdate><enddate>197512</enddate><creator>Beerens, E.G.J</creator><creator>Slot, J.W</creator><creator>Van Der Leun, J.C</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197512</creationdate><title>Rapid Regeneration Of The Dermal-Epidermal Junction After Partial Separation By Vacuum: An Electron Microscopic Study</title><author>Beerens, E.G.J ; Slot, J.W ; Van Der Leun, J.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-b9643f0636b4ccd35ba79a4afb69bbb15c48c3b83efd4e6491070f951bccc38b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Adult</topic><topic>Blister - pathology</topic><topic>Blister - physiopathology</topic><topic>Desmosomes - ultrastructure</topic><topic>Edema</topic><topic>Humans</topic><topic>Intercellular Junctions - ultrastructure</topic><topic>Male</topic><topic>Microscopy, Electron</topic><topic>Regeneration</topic><topic>Skin - injuries</topic><topic>Skin - physiopathology</topic><topic>Skin - ultrastructure</topic><topic>Vacuoles - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beerens, E.G.J</creatorcontrib><creatorcontrib>Slot, J.W</creatorcontrib><creatorcontrib>Van Der Leun, J.C</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of investigative dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beerens, E.G.J</au><au>Slot, J.W</au><au>Van Der Leun, J.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid Regeneration Of The Dermal-Epidermal Junction After Partial Separation By Vacuum: An Electron Microscopic Study</atitle><jtitle>Journal of investigative dermatology</jtitle><addtitle>J Invest Dermatol</addtitle><date>1975-12</date><risdate>1975</risdate><volume>65</volume><issue>6</issue><spage>513</spage><epage>521</epage><pages>513-521</pages><issn>0022-202X</issn><eissn>1523-1747</eissn><abstract>A process of rapid repair of dermal-epidermal adherence, as found in experiments with interrupted suction, was investigated electron microscopically. Biopsies in different stages of the process of suction blister formation and of the repair process were studied. Results show that suction blister formation occurs by successive detachment of hemidesmosomes from the basement membrane, and that, after partial separation of the epidermis from the dermis, a rapid regeneration of the dermal-epidermal junction takes place. This regeneration process apparently consists of two steps: realignment of basal cells to the basement membrane accompanied by autophagocytosis of detached hemidesmosomes, and de novo formation of hemidesmosomes. The time required for this structural regeneration corresponds well with the speed of the functional repair of dermal-epidermal adherence measured with the technique of interrupted suction.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>1194715</pmid><doi>10.1111/1523-1747.ep12610200</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of investigative dermatology, 1975-12, Vol.65 (6), p.513-521 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Blister - pathology Blister - physiopathology Desmosomes - ultrastructure Edema Humans Intercellular Junctions - ultrastructure Male Microscopy, Electron Regeneration Skin - injuries Skin - physiopathology Skin - ultrastructure Vacuoles - ultrastructure |
| title | Rapid Regeneration Of The Dermal-Epidermal Junction After Partial Separation By Vacuum: An Electron Microscopic Study |
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