Effects of activity in non-myelinated afferent fibres on the spinocervical tract
Microelectrode recordings were made from axons of the spinocervical tract (SCT) in unanaesthetized decerebrate-spinal cats. Pure volleys in non-myelinated (C) cutaneous nerve fibres were obtained by DC-polarization block of conduction in the myelinated (A) fibres, and SCT cells were classified accor...
Gespeichert in:
| Veröffentlicht in: | Brain research 1975-11, Vol.98 (2), p.243-259 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 259 |
|---|---|
| container_issue | 2 |
| container_start_page | 243 |
| container_title | Brain research |
| container_volume | 98 |
| creator | Brown, A.G. Hamann, W.C. Martin, H.F. |
| description | Microelectrode recordings were made from axons of the spinocervical tract (SCT) in unanaesthetized decerebrate-spinal cats. Pure volleys in non-myelinated (C) cutaneous nerve fibres were obtained by DC-polarization block of conduction in the myelinated (A) fibres, and SCT cells were classified according to whether or not they were excited by C fibres. The effects of conditioning C responses in the SCT with A and C fibre input were examined, as were the effects of conditioning A fibre responses in the tract with C fibre inputs. The effects of stimulating descending systems in the cervical spinal cord on the C-fibre-evoked responses of SCT cells were determined.
SCT units with a slowly-adapting pressure-sensitive component in their receptive fields responded to cutaneous C fibres in addition to A fibres. Units which responded only to hair movement when the receptive field was stimulated mechanically were not excited by C fibres. Responses in SCT neurones produced by C fibres were profoundly inhibited by conditioning volleys in A fibres of both ipsilateral and contralateral cutaneous nerves and by activity in several descending systems. Conditioning with C fibres failed to affect the responses of SCT cells to either A or C fibres.
It is concluded that cutaneous C fibres excite some SCT cells but have no other effect on transmission through this system. It is suggested that there are common inhibitory interneurones in the paths from descending systems and cutaneous A and C fibres to the excitatory input to SCT cells. |
| doi_str_mv | 10.1016/0006-8993(75)90004-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_83079937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0006899375900049</els_id><sourcerecordid>83079937</sourcerecordid><originalsourceid>FETCH-LOGICAL-c385t-626c9cbfc0e155b9ff5c134c29ed967d2bab0fee9c7c6a27d8c98d99327ebf0f3</originalsourceid><addsrcrecordid>eNp9kEtLAzEQx4P4qtVv4CEn0cNqsq9sLoKU-oCCHvQcsrMTjGyzNUkL_famD_TmaRjmN39mfoRccnbLGa_vGGN11khZXIvqRqauzOQBGfFG5Fmdl-yQjH6RU3IWwldqi0KyE3LMBWd5MyJvU2MQYqCDoRqiXdm4ptZRN7hsvsbeOh2xozpRHl2kxrYeE-1o_EQaFtYNgH5lQfc0-pRwTo6M7gNe7OuYfDxO3yfP2ez16WXyMMugaKqY7qtBQmuAIa-qVhpTAS9KyCV2shZd3uqWGUQJAmqdi64B2XTpkVxga5gpxuRql7vww_cSQ1RzGwD7XjsclkE1BRMJFwksdyD4IQSPRi28nWu_VpypjUe1kaQ2kpSo1Najkmntcp-_bOfY_S1txaXx_W6M6ceVRa8CWHSAnfXJp-oG-3_-D6Q5gyU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83079937</pqid></control><display><type>article</type><title>Effects of activity in non-myelinated afferent fibres on the spinocervical tract</title><source>Elsevier ScienceDirect Journals Complete - AutoHoldings</source><source>MEDLINE</source><creator>Brown, A.G. ; Hamann, W.C. ; Martin, H.F.</creator><creatorcontrib>Brown, A.G. ; Hamann, W.C. ; Martin, H.F.</creatorcontrib><description>Microelectrode recordings were made from axons of the spinocervical tract (SCT) in unanaesthetized decerebrate-spinal cats. Pure volleys in non-myelinated (C) cutaneous nerve fibres were obtained by DC-polarization block of conduction in the myelinated (A) fibres, and SCT cells were classified according to whether or not they were excited by C fibres. The effects of conditioning C responses in the SCT with A and C fibre input were examined, as were the effects of conditioning A fibre responses in the tract with C fibre inputs. The effects of stimulating descending systems in the cervical spinal cord on the C-fibre-evoked responses of SCT cells were determined.
SCT units with a slowly-adapting pressure-sensitive component in their receptive fields responded to cutaneous C fibres in addition to A fibres. Units which responded only to hair movement when the receptive field was stimulated mechanically were not excited by C fibres. Responses in SCT neurones produced by C fibres were profoundly inhibited by conditioning volleys in A fibres of both ipsilateral and contralateral cutaneous nerves and by activity in several descending systems. Conditioning with C fibres failed to affect the responses of SCT cells to either A or C fibres.
It is concluded that cutaneous C fibres excite some SCT cells but have no other effect on transmission through this system. It is suggested that there are common inhibitory interneurones in the paths from descending systems and cutaneous A and C fibres to the excitatory input to SCT cells.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(75)90004-9</identifier><identifier>PMID: 171028</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cats ; Decerebrate State ; Electric Stimulation ; Electrophysiology ; Nerve Fibers, Myelinated - physiology ; Neural Conduction ; Neural Inhibition ; Neural Pathways ; Neurons - physiology ; Neurons, Afferent - physiology ; Physical Stimulation ; Reaction Time ; Skin - innervation ; Spinal Cord - physiology ; Synaptic Transmission</subject><ispartof>Brain research, 1975-11, Vol.98 (2), p.243-259</ispartof><rights>1975 Elsevier Scientific Publishing Company, Amsterdam</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-626c9cbfc0e155b9ff5c134c29ed967d2bab0fee9c7c6a27d8c98d99327ebf0f3</citedby><cites>FETCH-LOGICAL-c385t-626c9cbfc0e155b9ff5c134c29ed967d2bab0fee9c7c6a27d8c98d99327ebf0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(75)90004-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/171028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, A.G.</creatorcontrib><creatorcontrib>Hamann, W.C.</creatorcontrib><creatorcontrib>Martin, H.F.</creatorcontrib><title>Effects of activity in non-myelinated afferent fibres on the spinocervical tract</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Microelectrode recordings were made from axons of the spinocervical tract (SCT) in unanaesthetized decerebrate-spinal cats. Pure volleys in non-myelinated (C) cutaneous nerve fibres were obtained by DC-polarization block of conduction in the myelinated (A) fibres, and SCT cells were classified according to whether or not they were excited by C fibres. The effects of conditioning C responses in the SCT with A and C fibre input were examined, as were the effects of conditioning A fibre responses in the tract with C fibre inputs. The effects of stimulating descending systems in the cervical spinal cord on the C-fibre-evoked responses of SCT cells were determined.
SCT units with a slowly-adapting pressure-sensitive component in their receptive fields responded to cutaneous C fibres in addition to A fibres. Units which responded only to hair movement when the receptive field was stimulated mechanically were not excited by C fibres. Responses in SCT neurones produced by C fibres were profoundly inhibited by conditioning volleys in A fibres of both ipsilateral and contralateral cutaneous nerves and by activity in several descending systems. Conditioning with C fibres failed to affect the responses of SCT cells to either A or C fibres.
It is concluded that cutaneous C fibres excite some SCT cells but have no other effect on transmission through this system. It is suggested that there are common inhibitory interneurones in the paths from descending systems and cutaneous A and C fibres to the excitatory input to SCT cells.</description><subject>Animals</subject><subject>Cats</subject><subject>Decerebrate State</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Nerve Fibers, Myelinated - physiology</subject><subject>Neural Conduction</subject><subject>Neural Inhibition</subject><subject>Neural Pathways</subject><subject>Neurons - physiology</subject><subject>Neurons, Afferent - physiology</subject><subject>Physical Stimulation</subject><subject>Reaction Time</subject><subject>Skin - innervation</subject><subject>Spinal Cord - physiology</subject><subject>Synaptic Transmission</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQx4P4qtVv4CEn0cNqsq9sLoKU-oCCHvQcsrMTjGyzNUkL_famD_TmaRjmN39mfoRccnbLGa_vGGN11khZXIvqRqauzOQBGfFG5Fmdl-yQjH6RU3IWwldqi0KyE3LMBWd5MyJvU2MQYqCDoRqiXdm4ptZRN7hsvsbeOh2xozpRHl2kxrYeE-1o_EQaFtYNgH5lQfc0-pRwTo6M7gNe7OuYfDxO3yfP2ez16WXyMMugaKqY7qtBQmuAIa-qVhpTAS9KyCV2shZd3uqWGUQJAmqdi64B2XTpkVxga5gpxuRql7vww_cSQ1RzGwD7XjsclkE1BRMJFwksdyD4IQSPRi28nWu_VpypjUe1kaQ2kpSo1Najkmntcp-_bOfY_S1txaXx_W6M6ceVRa8CWHSAnfXJp-oG-3_-D6Q5gyU</recordid><startdate>19751114</startdate><enddate>19751114</enddate><creator>Brown, A.G.</creator><creator>Hamann, W.C.</creator><creator>Martin, H.F.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19751114</creationdate><title>Effects of activity in non-myelinated afferent fibres on the spinocervical tract</title><author>Brown, A.G. ; Hamann, W.C. ; Martin, H.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-626c9cbfc0e155b9ff5c134c29ed967d2bab0fee9c7c6a27d8c98d99327ebf0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><topic>Animals</topic><topic>Cats</topic><topic>Decerebrate State</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Nerve Fibers, Myelinated - physiology</topic><topic>Neural Conduction</topic><topic>Neural Inhibition</topic><topic>Neural Pathways</topic><topic>Neurons - physiology</topic><topic>Neurons, Afferent - physiology</topic><topic>Physical Stimulation</topic><topic>Reaction Time</topic><topic>Skin - innervation</topic><topic>Spinal Cord - physiology</topic><topic>Synaptic Transmission</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brown, A.G.</creatorcontrib><creatorcontrib>Hamann, W.C.</creatorcontrib><creatorcontrib>Martin, H.F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brown, A.G.</au><au>Hamann, W.C.</au><au>Martin, H.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of activity in non-myelinated afferent fibres on the spinocervical tract</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1975-11-14</date><risdate>1975</risdate><volume>98</volume><issue>2</issue><spage>243</spage><epage>259</epage><pages>243-259</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Microelectrode recordings were made from axons of the spinocervical tract (SCT) in unanaesthetized decerebrate-spinal cats. Pure volleys in non-myelinated (C) cutaneous nerve fibres were obtained by DC-polarization block of conduction in the myelinated (A) fibres, and SCT cells were classified according to whether or not they were excited by C fibres. The effects of conditioning C responses in the SCT with A and C fibre input were examined, as were the effects of conditioning A fibre responses in the tract with C fibre inputs. The effects of stimulating descending systems in the cervical spinal cord on the C-fibre-evoked responses of SCT cells were determined.
SCT units with a slowly-adapting pressure-sensitive component in their receptive fields responded to cutaneous C fibres in addition to A fibres. Units which responded only to hair movement when the receptive field was stimulated mechanically were not excited by C fibres. Responses in SCT neurones produced by C fibres were profoundly inhibited by conditioning volleys in A fibres of both ipsilateral and contralateral cutaneous nerves and by activity in several descending systems. Conditioning with C fibres failed to affect the responses of SCT cells to either A or C fibres.
It is concluded that cutaneous C fibres excite some SCT cells but have no other effect on transmission through this system. It is suggested that there are common inhibitory interneurones in the paths from descending systems and cutaneous A and C fibres to the excitatory input to SCT cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>171028</pmid><doi>10.1016/0006-8993(75)90004-9</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8993 |
| ispartof | Brain research, 1975-11, Vol.98 (2), p.243-259 |
| issn | 0006-8993 1872-6240 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_83079937 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Cats Decerebrate State Electric Stimulation Electrophysiology Nerve Fibers, Myelinated - physiology Neural Conduction Neural Inhibition Neural Pathways Neurons - physiology Neurons, Afferent - physiology Physical Stimulation Reaction Time Skin - innervation Spinal Cord - physiology Synaptic Transmission |
| title | Effects of activity in non-myelinated afferent fibres on the spinocervical tract |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T12%3A34%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20activity%20in%20non-myelinated%20afferent%20fibres%20on%20the%20spinocervical%20tract&rft.jtitle=Brain%20research&rft.au=Brown,%20A.G.&rft.date=1975-11-14&rft.volume=98&rft.issue=2&rft.spage=243&rft.epage=259&rft.pages=243-259&rft.issn=0006-8993&rft.eissn=1872-6240&rft_id=info:doi/10.1016/0006-8993(75)90004-9&rft_dat=%3Cproquest_cross%3E83079937%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=83079937&rft_id=info:pmid/171028&rft_els_id=0006899375900049&rfr_iscdi=true |