Pituitary Inhibitory Effects of Digitoxin and Hydrocortisone.
Summary Digitoxin and hydrocortisone administered in a dose of 0.5 mg/100 g body weight daily did not significantly affect the growth rate of rats, although 1 mg/100 g of hydrocortisone markedly inhibited growth. Digitoxin and hydrocortisone caused atrophy of the adrenal glands but had no effect on...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1962-01, Vol.109 (1), p.10-14 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 109 |
| creator | Vernikos-Danellis, Joan Marks, Bernard H. |
| description | Summary
Digitoxin and hydrocortisone administered in a dose of 0.5 mg/100 g body weight daily did not significantly affect the growth rate of rats, although 1 mg/100 g of hydrocortisone markedly inhibited growth. Digitoxin and hydrocortisone caused atrophy of the adrenal glands but had no effect on the absolute weights of the testes, thyroid and anterior pituitary glands. Pretreatment of rats with a single dose of digitoxin did not prevent the stress-induced fall in adrenal ascorbic acid although chronic treatment completely prevented this effect in a manner quantitatively similar to hydrocortisone. Daily treatment with digitoxin or hydrocortisone for 30 days reduced the ACTH content of the anterior pituitary gland to 30-40% > that found in control glands. |
| doi_str_mv | 10.3181/00379727-109-27086 |
| format | Article |
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Digitoxin and hydrocortisone administered in a dose of 0.5 mg/100 g body weight daily did not significantly affect the growth rate of rats, although 1 mg/100 g of hydrocortisone markedly inhibited growth. Digitoxin and hydrocortisone caused atrophy of the adrenal glands but had no effect on the absolute weights of the testes, thyroid and anterior pituitary glands. Pretreatment of rats with a single dose of digitoxin did not prevent the stress-induced fall in adrenal ascorbic acid although chronic treatment completely prevented this effect in a manner quantitatively similar to hydrocortisone. Daily treatment with digitoxin or hydrocortisone for 30 days reduced the ACTH content of the anterior pituitary gland to 30-40% > that found in control glands.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-109-27086</identifier><identifier>PMID: 13925530</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Digitalis - pharmacology ; Digitalis Glycosides ; Digitoxin ; Hydrocortisone - pharmacology ; Old Medline ; Pituitary Diseases ; Pituitary Gland ; Pituitary Gland, Anterior - pharmacology</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1962-01, Vol.109 (1), p.10-14</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-f2110e6be490f93919f6defe72ebbbdefb10b17727460451e1e41d28377d853c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/13925530$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vernikos-Danellis, Joan</creatorcontrib><creatorcontrib>Marks, Bernard H.</creatorcontrib><title>Pituitary Inhibitory Effects of Digitoxin and Hydrocortisone.</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
Digitoxin and hydrocortisone administered in a dose of 0.5 mg/100 g body weight daily did not significantly affect the growth rate of rats, although 1 mg/100 g of hydrocortisone markedly inhibited growth. Digitoxin and hydrocortisone caused atrophy of the adrenal glands but had no effect on the absolute weights of the testes, thyroid and anterior pituitary glands. Pretreatment of rats with a single dose of digitoxin did not prevent the stress-induced fall in adrenal ascorbic acid although chronic treatment completely prevented this effect in a manner quantitatively similar to hydrocortisone. Daily treatment with digitoxin or hydrocortisone for 30 days reduced the ACTH content of the anterior pituitary gland to 30-40% > that found in control glands.</description><subject>Digitalis - pharmacology</subject><subject>Digitalis Glycosides</subject><subject>Digitoxin</subject><subject>Hydrocortisone - pharmacology</subject><subject>Old Medline</subject><subject>Pituitary Diseases</subject><subject>Pituitary Gland</subject><subject>Pituitary Gland, Anterior - pharmacology</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1962</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAQhS0EoqXwBxhQJra0PjuJ44EBlQKVKsEAsxUn5-KqjYudSPTf49IiNqZ7evru6e4Rcg10zKGECaVcSMFEClSmTNCyOCFDyHme8kLKUzLcA-meGJCLEFaUQi5YcU4GwCXLc06H5O7Vdr3tKr9L5u2H1bZzUc6MwboLiTPJg11G78u2SdU2yfOu8a52vrPBtTi-JGemWge8Os4ReX-cvU2f08XL03x6v0jrjIouNQyAYqExk9RILkGaokGDgqHWOioNVIOIh2YFzXJAwAwaVnIhmjLnNR-R20Pu1rvPHkOnNjbUuF5XLbo-qJJTUZYiiyA7gLV3IXg0auvtJn6ngKp9aeq3tGhI9VNaXLo5pvd6g83fyrGlCEwOQKiWqFau92389r_Ib1KJdKA</recordid><startdate>196201</startdate><enddate>196201</enddate><creator>Vernikos-Danellis, Joan</creator><creator>Marks, Bernard H.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>196201</creationdate><title>Pituitary Inhibitory Effects of Digitoxin and Hydrocortisone.</title><author>Vernikos-Danellis, Joan ; Marks, Bernard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-f2110e6be490f93919f6defe72ebbbdefb10b17727460451e1e41d28377d853c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1962</creationdate><topic>Digitalis - pharmacology</topic><topic>Digitalis Glycosides</topic><topic>Digitoxin</topic><topic>Hydrocortisone - pharmacology</topic><topic>Old Medline</topic><topic>Pituitary Diseases</topic><topic>Pituitary Gland</topic><topic>Pituitary Gland, Anterior - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vernikos-Danellis, Joan</creatorcontrib><creatorcontrib>Marks, Bernard H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vernikos-Danellis, Joan</au><au>Marks, Bernard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pituitary Inhibitory Effects of Digitoxin and Hydrocortisone.</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1962-01</date><risdate>1962</risdate><volume>109</volume><issue>1</issue><spage>10</spage><epage>14</epage><pages>10-14</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
Digitoxin and hydrocortisone administered in a dose of 0.5 mg/100 g body weight daily did not significantly affect the growth rate of rats, although 1 mg/100 g of hydrocortisone markedly inhibited growth. Digitoxin and hydrocortisone caused atrophy of the adrenal glands but had no effect on the absolute weights of the testes, thyroid and anterior pituitary glands. Pretreatment of rats with a single dose of digitoxin did not prevent the stress-induced fall in adrenal ascorbic acid although chronic treatment completely prevented this effect in a manner quantitatively similar to hydrocortisone. Daily treatment with digitoxin or hydrocortisone for 30 days reduced the ACTH content of the anterior pituitary gland to 30-40% > that found in control glands.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>13925530</pmid><doi>10.3181/00379727-109-27086</doi><tpages>5</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1962-01, Vol.109 (1), p.10-14 |
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| language | eng |
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| subjects | Digitalis - pharmacology Digitalis Glycosides Digitoxin Hydrocortisone - pharmacology Old Medline Pituitary Diseases Pituitary Gland Pituitary Gland, Anterior - pharmacology |
| title | Pituitary Inhibitory Effects of Digitoxin and Hydrocortisone. |
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